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2024 edition of the AHA/ACC/ACS/ASNC/HRS/SCA/SCCT SCMR/SVM association guidelines: the heart surgery, perioperative cardiovascular management practice reading
ZHAO Yilin, LUO Ailin
JOURNAL OF CLINICAL SURGERY    2025, 33 (1): 74-79.   DOI: 10.3969/j.issn.1005-6483.20241985
Abstract236)      PDF(pc) (1913KB)(1274)    PDF(mobile) (1913KB)(26)    Save
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Progress in the diagnosis of prostate cancer with the new generation of artificial intelligence
WANG Xuejing, HUANG Zhi, ZENG Jiabin, ZHOU Chuyun, ZHENG Bowen, LV Shidong, WEI Qiang
JOURNAL OF CLINICAL SURGERY    2025, 33 (2): 118-122.   DOI: 10.3969/j.issn.1005-6483.20242018
Abstract297)      PDF(pc) (972KB)(1430)       Save
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JOURNAL OF CLINICAL SURGERY    2022, 30 (4): 313-317.   DOI: 10.3969/j.issn.1005-6483.2022.04.005
Abstract296)      PDF(pc) (941KB)(1732)    PDF(mobile) (941KB)(44)    Save
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JOURNAL OF CLINICAL SURGERY    2019, 27 (3): 203-204.   DOI: 10.3969/j.issn.10056483.2019.03.008
Abstract364)      PDF(pc) (499KB)(1143)       Save
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Applications and advances of responsive neurostimulation in closed-loop epilepsy treatment
ZHANG Haocheng,LI Huaming,ZHU Junming,ZHANG Jianmin
JOURNAL OF CLINICAL SURGERY    2024, 32 (10): 1022-1025.   DOI: 10.3969/j.issn.1005-6483.2024.10.005
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Early clinical efficacy of posterior cervical single-door laminoplasty plus centerpiece titanium plate fixation for multi-segmental cervical spondylotic myelopathy
TAO Haiying, YANG Bo, WEI Ailin, et al.
JOURNAL OF CLINICAL SURGERY    2019, 27 (12): 1060-1062.   DOI: 10.3969/j.issn.1005-6483.2019.12.015
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Objective To investigate the early clinical effects of posterior cervical single-door laminoplasty plus centerpiece titanium plate fixation for multi-segmental cervical spondylotic myelopathy.Methods 35 patients suffering from cervical spondylotic myelopathy who underwent C3-C7 single-door centerpiece titanium plate fixation were reviewed retrospectively.The neurofunction was evaluated by comparing Japan Orthopaedic Association(JOA)score measured before and 12 months after surgery.X-ray,CT and MRI were performed before operation,7 days after operation,6 months after operation and 12 months after operation.The sagittal diameter of C5 spinal canal on the CT was measured before operation and 12 months after operation respectively,and the expansion rate of C5 spinal canal was calculated.The C2-C7 Cobb angle were measured to evaluate cervical curvature by means of X-ray measured before and 12 months after surgery.Results All patients were followed up for 12~24 months.Radiographic findings at follow-up period showed spinal canal enlarged perfectly,and no door closing or instrument failure.The average JOA score for preoperation was (8.43±1.09)and (13.94±1.66)at 12 months after operation,with the improvement rate of(65.68±16.15)%.The mean sagittal diameter of C5 spinal canal was (9.49±1.30)mm before operation and (16.70±1.97)mm at 12 months,with the improvement rate of (76.88±14.66)% .The C2-C7 Cobb angle had a decreasing trend at the 12 months follow-up compared with preoperative values,and there was significant difference(P<0.05).Conclusion Posterior cervical single-door laminoplasty plus centerpiece titanium plate fixation is reliable,nerve therapeutic effect and early clinical efficacy is satisfactory.
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Research progress of exosomes in soft tissue injuries in sports medicine
AIMAITI·Aili, WANG Zhiyong, HUANG Jifeng
JOURNAL OF CLINICAL SURGERY    2025, 33 (2): 213-216.   DOI: 10.3969/j.issn.1005-6483.20240421
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Sports medicine is often associated with soft tissue injuries,with tendon and ligament injuries being the most common sports injuries accounting for 30%~40% of all injuries.Mesenchymal stem cell exosomes have the ability to escape phagocytosis and realize long-term circulation,and can also be used as drug carriers of biological materials.The use of exosomes derived from mesenchymal stem cells for cell-free treatment of soft tissue injury is the current research direction in sports medicine.In this paper,the origin of exosomes in soft tissue regeneration is summarized,with emphasis on the biological mechanism of exosomes in soft tissue injury and the progress of diagnosis and treatment related to biomaterial.
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Research and application of cartilage organoids in cartilage repair
QIU Dewei, YANG Peng, TAO Jun
JOURNAL OF CLINICAL SURGERY    2025, 33 (4): 348-352.   DOI: 10.3969/j.issn.1005-6483.20250289
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In clinical research on articular cartilage injury repair,traditional treatment modalities can improve patients’ symptoms to a certain extent,but these approaches have limitations in long-term functional maintenance.In recent years,cartilage organoids (CORG) have drawn extensive attention due to their demonstrated potential advantages in the field of cartilage regeneration.This article aims to introduce the construction technology of CORG,providing a more promising application paradigm for cartilage repair.
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Accurate selection of mammoplasty methods for breast cancer
REN Min, XU Yunfeng
JOURNAL OF CLINICAL SURGERY    2021, 29 (3): 222-225.   DOI: 10.3969/j.issn.1005-6483.2021.03.006
Abstract282)      PDF(pc) (1015KB)(2804)    PDF(mobile) (1015KB)(8)    Save
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Analysis of prognostic factors of breast invasive papillary carcinoma
HAN Qiong, WU Bin, YUAN Maolin.
JOURNAL OF CLINICAL SURGERY    2020, 28 (2): 140-143.   DOI: 10.3969/j.issn.1005-6483.2020.02.013
Abstract642)      PDF(pc) (401KB)(1055)    PDF(mobile) (401KB)(12)    Save

Objective Analysis of prognostic factors of invasive papillary carcinoma of the breast.

Methods To obtain female cases of invasive papillary carcinoma of the breast that have been registered in the Surveillance,Epidemiology,and End Results Program(SEER)database in the United States since 1990.According to the inclusion and exclusion criteria,the subjects in accordance with this study were selected.The clinicopathological distribution of the study data was described,and the Cox proportional hazard regression model was used to analyze the prognostic factors by univariate and multivariate analysis.

Results A total of 1413 cases of invasive papillary carcinoma of the breast were included in this study,of which 106 cases died specifically.Cox univariate analysis showed that tissue differentiation,estrogen receptor(ER),progesterone receptor(PR),T stage,N stage,M stage,operation and chemotherapy were related factors affecting prognosis(P<0.05).Multivariate analysis showed that the higher the stage of lymph node metastasis,the higher the risk of poor prognosis.The risk of poor prognosis in stage T4 was 2.217times higher than that in stage T1(95%CI=1.056 to 4.655).The risk of death in the PR negative group was 2.136 times higher than that in the PR positive group(95%CI=1.252 to 3.644),and the risk of death in breast conserving surgery was 0.086 times higher than that in the unoperated group(95%CI=0.029 to 0.252).There was no significant difference in survival and prognosis between chemotherapy and chemotherapy(P=0.329,HR=0.787).

Conclusion Patients with large tumor,locally advanced tumor,lymph node metastasis,negative PR and no treatment had a higher risk of tumor specific death.Early surgical intervention of invasive papillary carcinoma can slow down the progression of the disease and improve the prognosis,adjuvant radiotherapy and chemotherapy have no significant effect on the overall survival and prognosis of patients.

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The operative selection and evaluation of circumcision in children of different ages
WANG Jun, CHEN Guiyou, ZHANG Yawei, et al.
JOURNAL OF CLINICAL SURGERY    2021, 29 (9): 876-879.   DOI: 10.3969/j.issn.1005-6483.2021.09.022
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Objective To evaluate the significance and reasonability of select in various types of circumcision in children of different ages.
Methods A retrospective analysis was performed for 1 440 children of different ages(3-15 years) between Jan 2019 and Sep 2019 in urological ward and ambulatory surgery area of our hospital.280 were preschool children,620 were school-age children,240 were adolescent children.In different ages,divide them into 4 groups by different types of circumcision:traditional circumcision group,circumcision group with ligation device,circumcision group with anastomoses device,circumcision group with stitching instrument.The indications such as blood loss、operating time、  pain duration、 shedding time、 short-term complication and long-term complication were compared.
Result Among the 4 surgical procedures,preschoolers had the shortest pain duration,shedding time and fewer short-term complication.School-age children had the lowest operative time and blood loss by circumcision with ligation device.Adolescent children had lower operative time,blood loss and the fewer long-term complication by circumcision with stitching instrument.
Conclusion With the development of circumcision apparatus,different surgical methods should be adopted for children's  circumcision in combination with different age.Traditional circumcision should be recommended for preschoolers,circumcision with ligation device for school-age children,circumcision with stitching instrument for adolescent children.
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JOURNAL OF CLINICAL SURGERY    2023, 31 (1): 4-6.   DOI: 10.3969/j.issn.1005-6483.2023.01.002
Abstract591)      PDF(pc) (354KB)(2169)    PDF(mobile) (354KB)(36)    Save
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Leucine-rich-alpha2-glycoprotein 1 regulates proliferation,migration and invasion of non-small cell lung cancer cells through RUNX1/OPN signaling
ZENG Qiang, ZHANG Yu, CHEN Hui, et al
JOURNAL OF CLINICAL SURGERY    2023, 31 (6): 562-567.   DOI: 10.3969/j.issn.1005-6483.2023.06.017
Abstract349)      PDF(pc) (1528KB)(866)       Save
Objective To investigate the regulatory effect of leucine-rich-alpha2-glycoprotein 1(LRG1) on the proliferation,migration and invasion of non-small cell lung cancer(NSCLC) cellsvia the Runt-related transcription factor 1(RUNX1)/osteopontin(OPN) axis. Methods To determin the expression of LRG1,RUNX1 and OPN in cultured human type II alveolar epithelial cells and human NSCLC cell lines A549,NCI-H838 and NCI-H1650.The human NSCLC cell line A549 cultured in vitro was randomly divided into control group,LRG1 knockdown group,negative control group,RUNX1 overexpression group,LRG1 knockdown + RUNX1 overexpression group by random number table method,after cells were grouped and transfected with plasmids,to detect the proliferation,apoptosis,migration,invasion,the expression of apoptosis proteins(Bcl-2,caspase-3,Bax) and epithelial-mesenchymal transition marker proteins(N-cadherin,E-cadherin),the expressions of LRG1,RUNX1 and OPN in A549 cells in each group.〖WTHZ〗Results Compared with human type II alveolar epithelial cells,the mRNA and protein expressions of LRG1,RUNX1 and OPN in human NSCLC cell lines A549,NCI-H838 and NCI-H1650 higher(P<0.05).Compared with the control group,the positive rate of EdU,the migration rate,the number of invasion,the mRNA and protein expressions of LRG1,RUNX1 and OPN,and the protein expression of Bcl-2 and N-cadherin in the LRG1 knockdown group were decreased(P<0.05),and the apoptosis rate and the protein expression of caspase-3,Bax,and E-cadherin were increased(P<0.05);The changes of various indicators in RUNX1 overexpression group were contrary to those in LRG1 knockdown group,and the overexpression of RUNX1 could reverse the effects of LRG1 knockdown on various indicators of cells.Conclusion Knockdown of LRG1 can inhibit the proliferation,migration and invasion of NSCLC cells and promote their apoptosis by down-regulating the expressions of RUNX1 and OPN.
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2024 Interpretation of the International Transfusion Medicine Collaboration Guidelines for intravenous albumin
JI Guangwei
JOURNAL OF CLINICAL SURGERY    2025, 33 (1): 84-88.   DOI: 10.3969/j.issn.1005-6483.20241943
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Interpretation of the 2021 European society of urology guidelines for the diagnosis and treatment of male anterior urethral stricture

GAN Shu, LI Bomou, HE Junwei, et al.
JOURNAL OF CLINICAL SURGERY    2022, 30 (1): 27-31.   DOI: 10.3969/j.issn.1005-6483.2022.01.009
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Interpretation of updated key points on Chinese society of clinical oncology’s primary liver cancer diagnosis and treatment guidelines (2024 edition)
HAN Ning, CHEN Chao, LIU Xiufeng
JOURNAL OF CLINICAL SURGERY    2025, 33 (1): 27-31.   DOI: 10.3969/j.issn.1005-6483.20241857
Abstract572)      PDF(pc) (1105KB)(375)    PDF(mobile) (1105KB)(13)    Save
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JOURNAL OF CLINICAL SURGERY    2023, 31 (6): 517-520.   DOI: 10.3969/j.issn.1005-6483.2023.06.005
Abstract341)      PDF(pc) (962KB)(1139)       Save
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Application effect of anterolateral femoral free flap transplantation based on three-dimensional reconstruction in CT angiography in the treatment of chronic osteomyelitis of the foot and ankle complicated with soft tissues defect
WEN Yang, YU Xiaojun, LAN Jiaping, CHEN Liyuan, LI Lei
JOURNAL OF CLINICAL SURGERY    2025, 33 (4): 365-369.   DOI: 10.3969/j.issn.1005-6483.20240571
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Objective To analyze the application effect of anterolateral femoral free flap transplantation based on three-dimensional reconstruction in CT angiography in the treatment of chronic osteomyelitis of the foot and ankle complicated with soft tissues defect.Methods A retrospective analysis was conducted on the clinical data of 105 patients with chronic osteomyelitis of the foot and ankle complicated with soft tissues defect who were admitted to Suining Central Hospital in Sichuan Province from January 2020 to January 2023.Patients enrolled were divided into the control group (n=52) and the observation group (n=53) according to different perforating blood vessel examination methods before surgery.The control group underwent anterolateral femoral free flap transplantation based on handheld Doppler ultrasound,while the observation group underwent anterolateral femoral free flap transplantation based on CTA three-dimensional reconstruction technology.Comparison between the groups was made on inflammatory factors (CRP,TNF-α and IL-6),skin flap repair effect,foot and ankle function (AOFAS) score,flap sensation,survival rate of skin flaps,and the incidence of adverse events.Results On day 14 after operation,serum CRP,TNF-α and IL-6 levels in the observation group were lower than those in the control group (P<0.05).Six months after operation,the effect of flap repair in observation group was better than that in control group,and the survival rate of flap was higher than that in control group (100.00% vs 92.31%) (P<0.05).Twelve months after operation,AOFAS score and flap sensation score of the observation group were higher (P<0.05).The incidence of adverse events was lower in the observation group than in the control group (3.77% vs.15.38%) (P<0.05).Conclusion Anterolateral femoral free flap transplantation based on CTA 3D reconstruction technique can repair soft tissue defect and reduce the risk of adverse events while can cure chronic osteomyelitis.
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JOURNAL OF CLINICAL SURGERY    2024, 32 (1): 37-40.   DOI: 10.3969/j.issn.1005-6483.2024.01.010
Abstract177)      PDF(pc) (1049KB)(1114)       Save
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Current status and progress of immunotherapy for pancreatic cancer
LIU Kun, WU Heshui.
JOURNAL OF CLINICAL SURGERY    2021, 29 (7): 687-690.   DOI: 10.3969/j.issn.1005-6483.2021.07.027
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Pancreatic cancer is a highly malignant disease in the digestive system.So far,surgical resection is still the primary treatment for pancreatic cancer,but only about 20% of pancreatic cancer patients can be treated with surgery.Even with comprehensive treatment measures such as surgery,radiotherapy and chemotherapy,biological therapy,and targeted therapy,the overall survival rate of pancreatic cancer patients has not been significantly improved in the past ten years.In recent years,immunotherapy has made breakthroughs in tumor treatment.Cancer immunotherapy has now been recognized as the fourth pillar of cancer treatment alongside surgery,radiotherapy,and chemotherapy.There are also many studies in the treatment of pancreatic cancer,but the results are not satisfactory.This article reviews the current status and possible prospects of immunotherapy for pancreatic cancer.
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Research and clinical progress of immunotherapy for gastric cancer
HUANG Tao, WANG Anxin, FU Guang
JOURNAL OF CLINICAL SURGERY    2024, 32 (1): 99-102.   DOI: 10.3969/j.issn.1005-6483.2024.01.027
Abstract1027)      PDF(pc) (655KB)(1071)       Save
晚期胃癌治疗选择有限,易发生化疗耐药。目前,包括免疫检查点抑制剂、过继细胞疗法、肿瘤疫苗、非特异免疫增强剂及细胞因子疗法在内的免疫疗法对胃癌显示出了良好的疗效。载体药物及3D打印技术也在临床前实验中取得了疗效。临床试验采用免疫肿瘤学单一疗法或联合免疫化学疗法来提高胃癌病人的总体生存时间和客观反应率。根据初步证据,我们相信免疫治疗可以积极影响自然病史,改善胃癌病人的预后。
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Interpretation of NCCN clinical practice guidelines in oncology: bone cancer (version 1.2020)
LI Mi, YANG Caihong
JOURNAL OF CLINICAL SURGERY    2021, 29 (1): 35-37.   DOI: 10.3969/j.issn.1005-6483.2021.01.012
Abstract477)      PDF(pc) (931KB)(1072)    PDF(mobile) (931KB)(11)    Save
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Programmed cell death 10 mediates the migration of glioma cells by regulating the PP2A/p38 signaling pathway
WAN Xueyan, XIE Jiazhao, ZHAO Kai, KONG Fanli, MEI Qi
JOURNAL OF CLINICAL SURGERY    2024, 32 (7): 693-696.   DOI: 10.3969/j.issn.1005-6483.2024.07.007
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Objective To explore the molecular mechanism of programmed cell death 10 (PDCD10) mediating glioma migration.Methods A PDCD10-silenced glioma cell line (U251) was constructed by siRNA,and the cells were treated with Okadaic Acid (OA),a protein phosphatase 2A (PP2A) phosphatase inhibitor,to investigate the effect of down-regulation of PDCD10 on the behavior of U251 cells; Western Blot (WB) was applied to detect the expression of PDCD10,PP2A,PP2Ac-307,p38 and pP38 in the control group and PDCD10 down-regulation group of U251 cells,to study the mechanism of PDCD10 regulation of PP2A/p38 signaling.Results Down-regulation of PDCD10 in U251 cells promoted the cells migration (P<0.05),which could be inhibited by PP2A phosphatase inhibitor OA (P<0.01).Further studies showed that down-regulation of PDCD10 promoted glioma cell migration via modulating the phosphorylation of PP2A,which in turn altered the activity of p38 (P<0.01).Conclusion PDCD10 may mediate glioma cell migration by regulating PP2A/p38 signaling.
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JOURNAL OF CLINICAL SURGERY    2018, 26 (11): 880-882.   DOI: 10.3969/j.issn.10056483.2018.11.026
Accepted: 03 December 2018
Online available: 03 December 2018

Abstract372)      PDF(pc) (303KB)(1636)       Save
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Standardized procedure for pancreaticoduodenectomy-Tongji university experience
CHEN Lin, DONG Hanhua, CHEN Qi, et al
JOURNAL OF CLINICAL SURGERY    2020, 28 (1): 5-7.   DOI: 10.3969/j.issn.1005-6483.2020.01.001
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JOURNAL OF CLINICAL SURGERY    2023, 31 (2): 117-121.   DOI: 10.3969/j.issn.1005-6483.2023.02.006
Abstract534)      PDF(pc) (1010KB)(1899)    PDF(mobile) (1010KB)(45)    Save
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JOURNAL OF CLINICAL SURGERY    2023, 31 (6): 501-505.   DOI: 10.3969/j.issn.1005-6483.2023.06.001
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Effect of Solifenacin on detrusor function and prognosis in patients with overactive bladder
JOURNAL OF CLINICAL SURGERY    2019, 27 (9): 798-800.   DOI: 10.3969/j.issn.1005-6483.2019.09.025
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Objective:To investigate the effect of Solifenacin on detrusor function and prognosis in patients with overactive bladder.Methods:128 cases of patients with overactive bladder admitted to our hospital from March 2016 to December 2018 were selected,and 64 cases were divided into control group and research group according to different treatment methods.The control group was treated with trotrodine and the research group with Solifenacin.The clinical efficacy of the two groups was compared and analyzed.Results:The bladder compliance of the study group,the number of bladder compression inhibition,the initial bladder urination,the maximum bladder volume,and the maximum urine flow rate[(53.1±26.4)ml/cm H2O,(1.5±1.2)times,(177.0±88.0)ml,(298.0±88.0)ml,(53.4±17.1)ml/s]was significantly better than the control group[(58.2±29.5)ml/cm H2O,(1.9±1.5)times,(155.0±90.0)ml,(275.0±98.0)ml,(54.0±20.1)ml/s,and the difference was statistically significant(P<0.05).The OABSS score(5.9±2.4)scores of the study group before and after medication were better than the control group(6.7±3.4),and the difference was statistically significant(P<0.05).The incidence of adverse events in the study group was 4.6% significantly lower than that in the control group(14.0%),and the difference was statistically significant(P<0.05).Conclusion:The use of solifenacin for the treatment of OAB patients,the clinical results are satisfactory,the adverse reactions are mild,it is worthy of clinical use.
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JOURNAL OF CLINICAL SURGERY    2023, 31 (10): 911-915.   DOI: 10.3969/j.issn.1005-6483.2023.10.004
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Application of continuous low negative pressure suction combined with drainage tube in rapid recovery after thoracoscopic surgery
JOURNAL OF CLINICAL SURGERY    2021, 29 (4): 360-362.   DOI: 10.3969/j.issn.1005-6483.2021.04.018
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Objective:To evaluate the advantage of negative pressure suction followed by thin thoracic tube after thoracoscope operation.Method:During January 2019 to December 2020, we performed 87 thoracoscope operations, and they were randomly divided into experimental group(47 cases) and control group(40 cases).the experimental group use negative pressure suction followed by thin thoracic tube after thoracoscope operation,otherwise,the control group use routine medium caliber thoracic tube to drainage pleural hydrocele,analyze the differences between two groups by statistical treated data on  the extubation time after operaton,the gross of pleural effusion after operaton,the levels of lactate dehydrogenase(LDH) at 24 hours after surgery.Result:The extubation time was significantly shortened in the experimental group(P<0.05).The gross of pleural effusion after operaton and the levels of lactate dehydrogenase(LDH) the moment ofafter surgery showed no significant between two groups(P>0.05).Conclusion:The experimental group can shorted time of bearing drainage tubes after thoracoscope operation;the negative pressure suction followed by thin thoracic tube can not cause additional damage to thoracic cavity,and facilitate enhanced recovery after surgery.
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JOURNAL OF CLINICAL SURGERY    2022, 30 (6): 510-513.   DOI: 10.3969/j.issn.1005-6483.2022.06.003
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Constructing a prognostic prediction model for distant metastatic hepatocellular carcinoma based upon SEER data
PAN Junhao, WANG Chunhui
JOURNAL OF CLINICAL SURGERY    2025, 33 (4): 410-415.   DOI: 10.3969/j.issn.1005-6483.20240167
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Objective To explore prognostic factors of patients with distant metastatic hepatocellular carcinoma (DMHCC) and construct a survival prognosis nomogram to predict cancer-specific survival (CSS) for DMHCC patients.Methods A total of 619 patients from the SEER database (2000-2018) were included after strict inclusion and exclusion criteria.They were randomly divided into two groups at a ratio of 7〖DK〗∶3,among which there were 433 cases in the training set and 186 cases in the validation set.Cox regression analysis was used to screen out the independent risk factors affecting the prognosis of patients with DMHCC,and a nomogram was constructed.The predictive accuracy of the nomogram was determined by concordance index (C-index),receiver operating characteristic(ROC) and calibration curves.The clinical net benefit of the nomogram was assessed using decision curve analysis (DCA).Kaplan-Meier survival curves and Log-rank tests were performed for examining survival differences between high and low-risk groups.Results Multivariate Cox regression analysis revealed that tumor size,degree of tumor differentiation,T stage,whether or not surgery,chemotherapy or radiotherapy were independent risk factors influencing the prognosis of DMHCC patients.The nomogram,based on these factors,demonstrated good predictive performance in the training set with a C-index of 0.720 (95%CI:0.693-0.747),and area under the ROC curve at1,2,and3 years was 0.790,0.778,and 0.795,respectively.In the validation set,the C-index was 0.673 (95%CI:0.626-0.720),and area under the ROC curve at 1,2,and 3 years was 0.741,0.782,and 0.824,respectively.Risk stratification was performed with the nomogram.Kaplan-Meier survival curve indicated that for both training and validation sets,low-risk group had a significantly better prognosis than high-risk group.Conclusion This prediction model exhibits good predictive efficacy,providing valuable support for clinical decision-making and personalized treatment strategies in DMHCC patients.
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Advances in pathogenesis,diagnosis and treatment of bile reflux
DONG Hongyi, LIU Diangang
JOURNAL OF CLINICAL SURGERY    2024, 32 (5): 554-557.   DOI: 10.3969/j.issn.1005-6483.2024.05.033
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Bile reflux is a common physiological phenomenon in the body,which is caused by the retrograde movement of bile into the stomach and above.Long-term bile reflux causes bile reflux gastritis.It can also lead to intestinal metaplasia,Barrett’s esophagus,and even gastric cancer,esophageal cancer,pharyngeal cancer risk factors.Therefore,long-term frequent bile reflux should be regarded as pathological bile reflux.bile reflux is divided into primary bile reflux and secondary bile reflux.The common clinical symptoms of bile reflux include abdominal distension,bitter mouth,upper abdominal pain,nausea and vomiting.Primary bile reflux can occur without transgastric surgery,whereas secondary bile reflux often occurs after gastrointestinal surgery.This article reviews the pathogenesis,diagnosis and corresponding treatment progress of bile reflux,so as to provide reference for further research on bile reflux.
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Clinical status and advances in targeted therapy for pancreatic cancer
GUO Keying, LI Shumin, CUI Jiujie
JOURNAL OF CLINICAL SURGERY    2024, 32 (7): 773-775.   DOI: 10.3969/j.issn.1005-6483.2024.07.028
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Pancreatic cancer has always been called the “king of cancer” due to its extremely high mortality.In recent years,the global incidence rate of pancreatic cancer has risen rapidly.Furthermore,pancreatic cancer is lack of effective therapeutic strategies and has seriously harmed human health.With the rapid development of precision therapy,targeted therapy for pancreatic cancer has also progressed rapidly.Although targeted therapy for pancreatic cancer has improved the prognosis of only a few patients,it has brought light to pancreatic cancer.This article reviews the research progress of therapeutic targets and related drugs for pancreatic cancer.
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The current situation of diagnosis and treatment of fibular tendon
NI Qubo, LV Jiahao, CHEN Liaobin
JOURNAL OF CLINICAL SURGERY    2025, 33 (4): 353-356.   DOI: 10.3969/j.issn.1005-6483.20250331
Abstract156)      PDF(pc) (1047KB)(144)    PDF(mobile) (1047KB)(6)    Save
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Interpretation of Chinese expert consensus on the diagnosis and treatment of inguinalhernia in the elderly (2019 edition)
TANG Jianxiong, LI Hangyu
JOURNAL OF CLINICAL SURGERY    2020, 28 (1): 12-15.   DOI: 10.3969/j.issn.1005-6483.2020.01.003
Abstract576)      PDF(pc) (436KB)(1348)    PDF(mobile) (436KB)(22)    Save
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Expression of X-linked inhibitor of apoptosis associated factor 1 and phosphoenolpyruvate carboxykinase 1 in Luminal B breast cancer and their relationship with prognosis
YAN Pingping, ZHANG Shaodong, GUO Jiaoliang, DOU Yandong
JOURNAL OF CLINICAL SURGERY    2025, 33 (1): 97-101.   DOI: 10.3969/j.issn.1005-6483.20231669
Abstract168)      PDF(pc) (1074KB)(460)    PDF(mobile) (1074KB)(2)    Save
[Abstract] Objective To investigate the expression of X-linked inhibitor of apoptosis associated factor 1 (XAF1) and phosphoenolpyruvate carboxykinase 1 (PCK1) in Luminal type B breast cancer and their relationship with the prognosis of patients.Methods From January 2016 to January 2018, 95 patients with Luminal B breast cancer underwent surgical treatment. Cancer tissues and adjacent tissues > 5 cm from the cancer tissues were collected during the operation.The positive expressions of XAF1 and PCK1 proteins were detected by immunohistochemistry.The relationship between XAF1 and PCK1 protein expression and clinicopathological features of breast cancer was analyzed, and the survival curves of breast cancer patients with different XAF1 and PCK1 protein expression were plotted by KaplanMeier method,the survival rate was compared by Log-rankn test. Multi-factor Cox-regression analysis was used to analyze the prognostic factors of breast cancer.Results GEPIA database analysis showed that the expression levels of XAF1 and PCK1 mRNA in breast cancer tissues were lower than those in normal tissues ( P<0.05).The positive expression rates of XAF1 and PCK1 proteins in cancer tissue were lower than adjacent tissues ( P<0.05).The positive expression of XAF1 in breast cancer tissue was related to clinical stage,lymph node metastasis and histological grade,Ki-67 expression status,while the positive expression of PCK1 was related to clinical stage,lymph node metastasis and Ki-67 expression status ( P<0.05).The 5-year overall survival rate of XAF1 positive expression patients was higher than that of negative expression patients (Log-rank χ2=5.101, P=0.024),and the 5-year overall survival rate of PCK1 positive expression patients was higher than that of negative expression patients (Log-rank χ2=6.515, P=0.011).Clinical stage Ⅲ,negative expression of XAF1,and negative expression of PCK1 were risk factors for poor prognosis ( P<0.05).Conclusion The positive expression rates of XAF1 and PCK1 in Luminal B type breast cancer tissue are reduced,which is related to some clinicopathological characteristics and 5-year survival rate after surgery.The 5-year survival rate was lower in patients with negative XAFI and PCKI expression.
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JOURNAL OF CLINICAL SURGERY    2022, 30 (12): 1101-1103.   DOI: 10.3969/j.issn.1005-6483.2022.12.001
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Deep brain stimulation and brain-computer interface technology:Interdisciplinary convergence of neuroscience, engineering, and clinical medicine
XIONG Botao,ZHANG Wei,WANG Wei
JOURNAL OF CLINICAL SURGERY    2024, 32 (10): 1019-1021.   DOI: 10.3969/j.issn.1005-6483.2024.10.004
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Indication and opportunity of surgical treatment for chronic mastitis
JOURNAL OF CLINICAL SURGERY    2019, 27 (3): 262-264.   DOI: 10.3969/j.issn.10056483.2019.03.027
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Chronic mastitis is a benign inflammatory condition of the breast with unknown etiology,which can be easily misdiagnosed as carcinoma.Timely diagnosis and treatment are critical to improve the prognosis.As one of the main treatment,surgical intervention at the right time can have a positive therapeutic effect.Therefore,this article will emphasize on surgical treatment as well as the appropriate timing to provide help for dealing with this disease.
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