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Progress in the diagnosis of prostate cancer with the new generation of artificial intelligence
WANG Xuejing, HUANG Zhi, ZENG Jiabin, ZHOU Chuyun, ZHENG Bowen, LV Shidong, WEI Qiang
JOURNAL OF CLINICAL SURGERY    2025, 33 (2): 118-122.   DOI: 10.3969/j.issn.1005-6483.20242018
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Research and application of cartilage organoids in cartilage repair
QIU Dewei, YANG Peng, TAO Jun
JOURNAL OF CLINICAL SURGERY    2025, 33 (4): 348-352.   DOI: 10.3969/j.issn.1005-6483.20250289
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In clinical research on articular cartilage injury repair,traditional treatment modalities can improve patients’ symptoms to a certain extent,but these approaches have limitations in long-term functional maintenance.In recent years,cartilage organoids (CORG) have drawn extensive attention due to their demonstrated potential advantages in the field of cartilage regeneration.This article aims to introduce the construction technology of CORG,providing a more promising application paradigm for cartilage repair.
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JOURNAL OF CLINICAL SURGERY    2022, 30 (4): 313-317.   DOI: 10.3969/j.issn.1005-6483.2022.04.005
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The operative selection and evaluation of circumcision in children of different ages
WANG Jun, CHEN Guiyou, ZHANG Yawei, et al.
JOURNAL OF CLINICAL SURGERY    2021, 29 (9): 876-879.   DOI: 10.3969/j.issn.1005-6483.2021.09.022
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Objective To evaluate the significance and reasonability of select in various types of circumcision in children of different ages.
Methods A retrospective analysis was performed for 1 440 children of different ages(3-15 years) between Jan 2019 and Sep 2019 in urological ward and ambulatory surgery area of our hospital.280 were preschool children,620 were school-age children,240 were adolescent children.In different ages,divide them into 4 groups by different types of circumcision:traditional circumcision group,circumcision group with ligation device,circumcision group with anastomoses device,circumcision group with stitching instrument.The indications such as blood loss、operating time、  pain duration、 shedding time、 short-term complication and long-term complication were compared.
Result Among the 4 surgical procedures,preschoolers had the shortest pain duration,shedding time and fewer short-term complication.School-age children had the lowest operative time and blood loss by circumcision with ligation device.Adolescent children had lower operative time,blood loss and the fewer long-term complication by circumcision with stitching instrument.
Conclusion With the development of circumcision apparatus,different surgical methods should be adopted for children's  circumcision in combination with different age.Traditional circumcision should be recommended for preschoolers,circumcision with ligation device for school-age children,circumcision with stitching instrument for adolescent children.
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Accurate selection of mammoplasty methods for breast cancer
REN Min, XU Yunfeng
JOURNAL OF CLINICAL SURGERY    2021, 29 (3): 222-225.   DOI: 10.3969/j.issn.1005-6483.2021.03.006
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JOURNAL OF CLINICAL SURGERY    2023, 31 (1): 4-6.   DOI: 10.3969/j.issn.1005-6483.2023.01.002
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JOURNAL OF CLINICAL SURGERY    2023, 31 (2): 117-121.   DOI: 10.3969/j.issn.1005-6483.2023.02.006
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Current status and progress of immunotherapy for pancreatic cancer
LIU Kun, WU Heshui.
JOURNAL OF CLINICAL SURGERY    2021, 29 (7): 687-690.   DOI: 10.3969/j.issn.1005-6483.2021.07.027
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Pancreatic cancer is a highly malignant disease in the digestive system.So far,surgical resection is still the primary treatment for pancreatic cancer,but only about 20% of pancreatic cancer patients can be treated with surgery.Even with comprehensive treatment measures such as surgery,radiotherapy and chemotherapy,biological therapy,and targeted therapy,the overall survival rate of pancreatic cancer patients has not been significantly improved in the past ten years.In recent years,immunotherapy has made breakthroughs in tumor treatment.Cancer immunotherapy has now been recognized as the fourth pillar of cancer treatment alongside surgery,radiotherapy,and chemotherapy.There are also many studies in the treatment of pancreatic cancer,but the results are not satisfactory.This article reviews the current status and possible prospects of immunotherapy for pancreatic cancer.
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JOURNAL OF CLINICAL SURGERY    2018, 26 (11): 880-882.   DOI: 10.3969/j.issn.10056483.2018.11.026
Accepted: 03 December 2018
Online available: 03 December 2018

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Interpretation of the 2021 European society of urology guidelines for the diagnosis and treatment of male anterior urethral stricture

GAN Shu, LI Bomou, HE Junwei, et al.
JOURNAL OF CLINICAL SURGERY    2022, 30 (1): 27-31.   DOI: 10.3969/j.issn.1005-6483.2022.01.009
Abstract357)      PDF(pc) (1016KB)(1878)    PDF(mobile) (1016KB)(12)    Save
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JOURNAL OF CLINICAL SURGERY    2023, 31 (6): 517-520.   DOI: 10.3969/j.issn.1005-6483.2023.06.005
Abstract318)      PDF(pc) (962KB)(1027)       Save
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Applications and advances of responsive neurostimulation in closed-loop epilepsy treatment
ZHANG Haocheng,LI Huaming,ZHU Junming,ZHANG Jianmin
JOURNAL OF CLINICAL SURGERY    2024, 32 (10): 1022-1025.   DOI: 10.3969/j.issn.1005-6483.2024.10.005
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2024 edition of the AHA/ACC/ACS/ASNC/HRS/SCA/SCCT SCMR/SVM association guidelines: the heart surgery, perioperative cardiovascular management practice reading
ZHAO Yilin, LUO Ailin
JOURNAL OF CLINICAL SURGERY    2025, 33 (1): 74-79.   DOI: 10.3969/j.issn.1005-6483.20241985
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JOURNAL OF CLINICAL SURGERY    2022, 30 (2): 109-111.   DOI: 10.3969/j.issn.1005-6483.2022.02.003
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JOURNAL OF CLINICAL SURGERY    2022, 30 (5): 416-419.   DOI: 10.3969/j.issn.1005-6483.2022.05.005
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Construction and application of the best evidence-based practice program for nasogastric tube insertion
LI Yan, SU Lan, FENG Li.
JOURNAL OF CLINICAL SURGERY    2021, 29 (11): 1040-1043.   DOI: 10.3969/j.issn.1005-6483.2021.11.013
Abstract525)      PDF(pc) (788KB)(1257)    PDF(mobile) (788KB)(29)    Save
Objective To explore the clinical practice of best evidence-based practice program for nasogastric tube insertion and evaluate its application.
Methods By referencing to Australia JBI model for evidence-based healthcare, we retrieved and summarized the best evidence for preoperative insertion of nasogastric tube, judged the position of nasogastric tube and alleviated the discomfort caused by the nasogastric tube insertion.Then we formed inspection indicators, maded baseline inspections before application of the best evidence on 29 medical staffs and 50 patients who met the inclusion criteria in department of hepatobiliary surgery, took transformative measures to boost application of the best evidence, and made post-application inspections to evlaute the effect.
Results After the application of the best evidence, the routine operation process of gastric tube insertion was improved; the awareness rate of audit indicators in medical staffs, audit indicators implementation rate, and the correct rate of gastric tube implantation were significantly improved (P<0.05 for all).
Conclusion The summarization and application of the best evidence for preoperative nasogastric tube insertion can improve medical staffs' operation level of nasogastric tube insertion,standardize the operation behaviors,reduce the patients' discomfort caused by the nasogastric tube insertion and improve their satisfaction.
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Leucine-rich-alpha2-glycoprotein 1 regulates proliferation,migration and invasion of non-small cell lung cancer cells through RUNX1/OPN signaling
ZENG Qiang, ZHANG Yu, CHEN Hui, et al
JOURNAL OF CLINICAL SURGERY    2023, 31 (6): 562-567.   DOI: 10.3969/j.issn.1005-6483.2023.06.017
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Objective To investigate the regulatory effect of leucine-rich-alpha2-glycoprotein 1(LRG1) on the proliferation,migration and invasion of non-small cell lung cancer(NSCLC) cellsvia the Runt-related transcription factor 1(RUNX1)/osteopontin(OPN) axis. Methods To determin the expression of LRG1,RUNX1 and OPN in cultured human type II alveolar epithelial cells and human NSCLC cell lines A549,NCI-H838 and NCI-H1650.The human NSCLC cell line A549 cultured in vitro was randomly divided into control group,LRG1 knockdown group,negative control group,RUNX1 overexpression group,LRG1 knockdown + RUNX1 overexpression group by random number table method,after cells were grouped and transfected with plasmids,to detect the proliferation,apoptosis,migration,invasion,the expression of apoptosis proteins(Bcl-2,caspase-3,Bax) and epithelial-mesenchymal transition marker proteins(N-cadherin,E-cadherin),the expressions of LRG1,RUNX1 and OPN in A549 cells in each group.〖WTHZ〗Results Compared with human type II alveolar epithelial cells,the mRNA and protein expressions of LRG1,RUNX1 and OPN in human NSCLC cell lines A549,NCI-H838 and NCI-H1650 higher(P<0.05).Compared with the control group,the positive rate of EdU,the migration rate,the number of invasion,the mRNA and protein expressions of LRG1,RUNX1 and OPN,and the protein expression of Bcl-2 and N-cadherin in the LRG1 knockdown group were decreased(P<0.05),and the apoptosis rate and the protein expression of caspase-3,Bax,and E-cadherin were increased(P<0.05);The changes of various indicators in RUNX1 overexpression group were contrary to those in LRG1 knockdown group,and the overexpression of RUNX1 could reverse the effects of LRG1 knockdown on various indicators of cells.Conclusion Knockdown of LRG1 can inhibit the proliferation,migration and invasion of NSCLC cells and promote their apoptosis by down-regulating the expressions of RUNX1 and OPN.
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JOURNAL OF CLINICAL SURGERY    2021, 29 (4): 310-313.   DOI: 10.3969/j.issn.1005-6483.2021.04.003
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JOURNAL OF CLINICAL SURGERY    2023, 31 (6): 514-516.   DOI: 10.3969/j.issn.1005-6483.2023.06.004
Abstract310)      PDF(pc) (957KB)(1099)       Save
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JOURNAL OF CLINICAL SURGERY    2019, 27 (5): 363-366.   DOI: 10.3969/j.issn.1005-6483.2019.05.002
Abstract428)      PDF(pc) (432KB)(1381)       Save
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JOURNAL OF CLINICAL SURGERY    2022, 30 (6): 510-513.   DOI: 10.3969/j.issn.1005-6483.2022.06.003
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Expression of X-linked inhibitor of apoptosis associated factor 1 and phosphoenolpyruvate carboxykinase 1 in Luminal B breast cancer and their relationship with prognosis
YAN Pingping, ZHANG Shaodong, GUO Jiaoliang, DOU Yandong
JOURNAL OF CLINICAL SURGERY    2025, 33 (1): 97-101.   DOI: 10.3969/j.issn.1005-6483.20231669
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[Abstract] Objective To investigate the expression of X-linked inhibitor of apoptosis associated factor 1 (XAF1) and phosphoenolpyruvate carboxykinase 1 (PCK1) in Luminal type B breast cancer and their relationship with the prognosis of patients.Methods From January 2016 to January 2018, 95 patients with Luminal B breast cancer underwent surgical treatment. Cancer tissues and adjacent tissues > 5 cm from the cancer tissues were collected during the operation.The positive expressions of XAF1 and PCK1 proteins were detected by immunohistochemistry.The relationship between XAF1 and PCK1 protein expression and clinicopathological features of breast cancer was analyzed, and the survival curves of breast cancer patients with different XAF1 and PCK1 protein expression were plotted by KaplanMeier method,the survival rate was compared by Log-rankn test. Multi-factor Cox-regression analysis was used to analyze the prognostic factors of breast cancer.Results GEPIA database analysis showed that the expression levels of XAF1 and PCK1 mRNA in breast cancer tissues were lower than those in normal tissues ( P<0.05).The positive expression rates of XAF1 and PCK1 proteins in cancer tissue were lower than adjacent tissues ( P<0.05).The positive expression of XAF1 in breast cancer tissue was related to clinical stage,lymph node metastasis and histological grade,Ki-67 expression status,while the positive expression of PCK1 was related to clinical stage,lymph node metastasis and Ki-67 expression status ( P<0.05).The 5-year overall survival rate of XAF1 positive expression patients was higher than that of negative expression patients (Log-rank χ2=5.101, P=0.024),and the 5-year overall survival rate of PCK1 positive expression patients was higher than that of negative expression patients (Log-rank χ2=6.515, P=0.011).Clinical stage Ⅲ,negative expression of XAF1,and negative expression of PCK1 were risk factors for poor prognosis ( P<0.05).Conclusion The positive expression rates of XAF1 and PCK1 in Luminal B type breast cancer tissue are reduced,which is related to some clinicopathological characteristics and 5-year survival rate after surgery.The 5-year survival rate was lower in patients with negative XAFI and PCKI expression.
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Prevention and management of severe complications during and after minimally invasive pancreatic surgery
LIU Jianhua
JOURNAL OF CLINICAL SURGERY    2021, 29 (7): 613-615.   DOI: 10.3969/j.issn.1005-6483.2021.07.005
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The perioperative application of erector spinae plane block
LIN Daoyi,YE Peng,GONG Cansheng,WANG Danfeng,ZHENG Ting,ZHENG Xiaochun
JOURNAL OF CLINICAL SURGERY    2024, 32 (6): 657-660.   DOI: 10.3969/j.issn.1005-6483.2024.06.027
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The erector spinae plane block(ESPB) technique proposed by Forero et al.has drawn increasing attention due to its reliable effects and fewer complications in simple and safe procedures.It has been successfully applied in anesthesia management during the perioperative period.This article mainly introduces the anatomical basis,possible mechanism of action,common operating methods,and clinical applications during the perioperative period of ESPB.Starting from the advantages,disadvantages,and complications of ESPB,it compares ESPB with other common thoracolumbar analgesic methods,providing better evidence support for the perioperative application and future development of ESPB.
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JOURNAL OF CLINICAL SURGERY    2020, 28 (10): 996-998.   DOI: 10.3969/j.issn.1005-6483.2020.10.030
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Study on the clinical application of silver ion antibacterial dressing in the incision and drainage of abscess
LIU Siyang, WANG Xiaoli, LI Lan, et al.
JOURNAL OF CLINICAL SURGERY    2020, 28 (12): 1116-1118.   DOI: 10.3969/j.issn.1005-6483.2020.12.006
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Objective To compare the therapeutic effect of silver ion antibacterial dressing and povidone iodine gauze on the incision and drainage of the abscess.
Methods From March 2019 to November 2019,62 patients were included in this study,and divided randomly into the observation group and the control group with 31 cases in each group.The patients in the observation group were treated with silver ion antibacterial dressing,while the patients in the control group were treated with povidone iodine gauze.The patients in the two groups were recorded in detail.The infection control time of abscess incision was compared before treatment,the third day and the second week after the first treatment,the number of dressing changes and wound healing time of the two groups,and the clinical effect of the patients was evaluated.
Results .The time of wound control in the observation group was (13.9±1.81)d,shorter than that in the control group (23.4±2.32)d(P<0.05);the BWATBWAT(Bates-Jensen Wound  assessment tool,BWAT) score of the observation group in the second week after the first treatment was (14.98±1.51),lower than that in the control group (19.78±2.46)(P<0.05);the times of drug change and wound healing in the Observation group were significantly shorter than that in the control group(P<0.05).
Conclusion Compared with the traditional povidone iodine gauze,the silver ion antibacterial dressing can control the wound infection and improve the wound healing more quickly,and the dressing change times are less,the wound healing time is obviously shortened.
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JOURNAL OF CLINICAL SURGERY    2022, 30 (2): 115-117.   DOI: 10.3969/j.issn.1005-6483.2022.02.005
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Improvement and effect evaluation of drainage tube orifice indwelling technique after single port video assisted thoracoscopic lung cancer surgery
HAN Leyang, ZHAO Long, DING Zhenyang
JOURNAL OF CLINICAL SURGERY    2023, 31 (2): 172-175.   DOI: 10.3969/j.issn.1005-6483.2023.02.022
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Objective To explore the feasibility of improving the indwelling technique of drainage tube orifice after single-port thoracoscopic lung cancer surgery and analysis of drainage effect.Methods The clinical data of 80 patients who underwent single-port thoracoscopic radical resection of lung cancer who were admitted to Ningbo Huamei Hospital,University of Chinese Academy of Sciences from January to December 2021 were retrospectively analyzed,and they were divided into observation group and control group according to the different drainage tube indwelling techniques.Postoperative drainage tube indwelling time,postoperative hospital stay,postoperative total drainage volume,intraoperative blood loss,operative time,incision infection,postoperative pain score,and drainage port healing.Results The postoperative incision exudation,poor incision healing,incision infection,drainage tube indwelling time,and postoperative hospital stay in the observation group were better than those in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in the total drainage volume,intraoperative blood loss,operation time,and secondary suture rate of the incision(P>0.05).Conclusion The single-port thoracoscopic surgery is beneficial to reduce the incidence of postoperative incision infection and incision exudation,shorten the indwelling time of the drainage tube,improve the safety of extubation,and shorten the hospitalization of patients.time.
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Expert consensus on minimally invasive surgery for elderly patients with hip fracture in China
CAO Faqi and YAN Chenchen and XUE Hang contributed equally to this Consensus
JOURNAL OF CLINICAL SURGERY    2022, 30 (4): 394-400.   DOI: 10.3969/j.issn.1005-6483.2022.04.028
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When the elderly patients with hip fracture receive surgical treatment,they often face a high risk of unfavorable prognosis due to the influence of multiple complications,which reduces their quality of life and also brings certain economic burden to the society.Therefore,minimally invasive treatment techniques for elderly hip fracture have been developing to improve the prognosis of elderly hip fracture patients.Based on the epidemiology of elderly hip fracture and the results of domestic and foreign literature review and expert investigation,this consensus summarizes the classification,surgical path and rehabilitation measures of elderly hip fracture,to provide a reasonable and standard treatment plan for minimally invasive surgical treatment of elderly hip fracture.
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Clinical features and diagnostic criteria of hepatobiliary duct cell carcinoma
LIN Ximeng, CHEN Minshan
JOURNAL OF CLINICAL SURGERY    2021, 29 (11): 1004-1007.   DOI: 10.3969/j.issn.1005-6483.2021.11.002
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Current status of diagnosis and treatment of Budd Chiari syndrome
JOURNAL OF CLINICAL SURGERY    2020, 28 (6): 593-595.   DOI: 10.3969/j.issn.1005-6483.2020.06.030
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BuddChiari syndrome is rare disorder by hepatic venous outflow obstraction and resulting portal hypertension and(or)hypertension of infeior vena cava.Etiological factors include hypercoagulable conditions,myeloproliferative desenses and enviroment conditions.The diagnosis is establisbed by demonstrating obstruction of hepatic venous outflow by ultrasound,computed tomography or magnetic resonance.The main goals of treatment are to ameliorate hepatic congestion and prevent further thrombosis.The selective use of anticoagulation,revascularization,transjugular intrahepatic portosystemic shunt has resulted in a significant increase.Orthotopic liver transplant should be used as a rescue therapy.The epidemiology,etiology and pathogenesis,diagnosis,mangement and longterm followup of patiens with budd-Chiari syndrome is reviewed.
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Application of continuous low negative pressure suction combined with drainage tube in rapid recovery after thoracoscopic surgery
JOURNAL OF CLINICAL SURGERY    2021, 29 (4): 360-362.   DOI: 10.3969/j.issn.1005-6483.2021.04.018
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Objective:To evaluate the advantage of negative pressure suction followed by thin thoracic tube after thoracoscope operation.Method:During January 2019 to December 2020, we performed 87 thoracoscope operations, and they were randomly divided into experimental group(47 cases) and control group(40 cases).the experimental group use negative pressure suction followed by thin thoracic tube after thoracoscope operation,otherwise,the control group use routine medium caliber thoracic tube to drainage pleural hydrocele,analyze the differences between two groups by statistical treated data on  the extubation time after operaton,the gross of pleural effusion after operaton,the levels of lactate dehydrogenase(LDH) at 24 hours after surgery.Result:The extubation time was significantly shortened in the experimental group(P<0.05).The gross of pleural effusion after operaton and the levels of lactate dehydrogenase(LDH) the moment ofafter surgery showed no significant between two groups(P>0.05).Conclusion:The experimental group can shorted time of bearing drainage tubes after thoracoscope operation;the negative pressure suction followed by thin thoracic tube can not cause additional damage to thoracic cavity,and facilitate enhanced recovery after surgery.
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Research progress of articular cartilage repair of the knee in children and adolescents
〗SHI Jiaqi, LI Haohuan, PENG Fei, et al.
JOURNAL OF CLINICAL SURGERY    2018, 26 (11): 886-890.   DOI: 10.3969/j.issn.10056483.2018.11.028
Accepted: 03 December 2018
Online available: 03 December 2018

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   Children and adolescents are increasingly suffering from articular cartilage and osteochondral deficiencies Traumatic incidents often result in damage to the joint surfaces,Surgery is indicated in young patients when conservative measures fail.The operative techniques for articular cartilage injuries traditionally performed in adults may be performed in children,while an individualized approach must be tailored according to patient and defect characteristics.Autologous chondrocyte transplantation has good biological potential,especially for large cartilage defects on the joint surface.In recent years,emerging PRP and tissue engineering technologies have not been reported in children and adolescents.Clear guidelines for defect dimensionassociated techniques have not been reported.Knee joint dimensions must be considered and correlated with respect to the cartilage defect size.In addition,the damage of the subchondral bone can not be ignored.Articular cartilage repair techniques appear to be safe in this cohort of patients,and no differences in complication rates have been reported when compared with adult patients.
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Current situation and progress of scar treatment
GAO Zhen, WU Xiaoli, LI Qingfeng
JOURNAL OF CLINICAL SURGERY    2020, 28 (12): 1106-1109.   DOI: 10.3969/j.issn.1005-6483.2020.12.003
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JOURNAL OF CLINICAL SURGERY    2023, 31 (1): 42-45.   DOI: 10.3969/j.issn.1005-6483.2023.01.013
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Advances in articular cartilage repair and regeneration
JOURNAL OF CLINICAL SURGERY    2021, 29 (4): 301-304.   DOI: 10.3969/j.issn.1005-6483.2021.04.001
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Unlike the majority of other tissues,cartilage is low in cellularity and basically avascular in nature,therefore,chondral lesions due to injury commonly result in the development of osteoarthritis,eventually leading to progressive total joint destruction.Current clinical treatment strategies for cartilage defects include microfracture,osteochondral autografts and allografts.Although they are often used clinically,significant drawbacks and limitations still exist.To solve these problems,cartilage tissue engineering has been recommended to promote more effective treatments.In this review,we discuss current clinical approaches for repairing cartilage,as well as cartilage tissue engineering approaches which are currently developing.We also describe potential future directions in cartilage regeneration.
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Research progress of exosomes in soft tissue injuries in sports medicine
AIMAITI·Aili, WANG Zhiyong, HUANG Jifeng
JOURNAL OF CLINICAL SURGERY    2025, 33 (2): 213-216.   DOI: 10.3969/j.issn.1005-6483.20240421
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Sports medicine is often associated with soft tissue injuries,with tendon and ligament injuries being the most common sports injuries accounting for 30%~40% of all injuries.Mesenchymal stem cell exosomes have the ability to escape phagocytosis and realize long-term circulation,and can also be used as drug carriers of biological materials.The use of exosomes derived from mesenchymal stem cells for cell-free treatment of soft tissue injury is the current research direction in sports medicine.In this paper,the origin of exosomes in soft tissue regeneration is summarized,with emphasis on the biological mechanism of exosomes in soft tissue injury and the progress of diagnosis and treatment related to biomaterial.
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Interpretation of Chinese expert consensus on the diagnosis and treatment of inguinalhernia in the elderly (2019 edition)
TANG Jianxiong, LI Hangyu
JOURNAL OF CLINICAL SURGERY    2020, 28 (1): 12-15.   DOI: 10.3969/j.issn.1005-6483.2020.01.003
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JOURNAL OF CLINICAL SURGERY    2023, 31 (6): 509-513.   DOI: 10.3969/j.issn.1005-6483.2023.06.003
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JOURNAL OF CLINICAL SURGERY    2022, 30 (2): 112-114.   DOI: 10.3969/j.issn.1005-6483.2022.02.004
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