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Progress in the diagnosis of prostate cancer with the new generation of artificial intelligence
WANG Xuejing, HUANG Zhi, ZENG Jiabin, ZHOU Chuyun, ZHENG Bowen, LV Shidong, WEI Qiang
JOURNAL OF CLINICAL SURGERY    2025, 33 (2): 118-122.   DOI: 10.3969/j.issn.1005-6483.20242018
Abstract286)      PDF(pc) (972KB)(1373)       Save
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2024 edition of the AHA/ACC/ACS/ASNC/HRS/SCA/SCCT SCMR/SVM association guidelines: the heart surgery, perioperative cardiovascular management practice reading
ZHAO Yilin, LUO Ailin
JOURNAL OF CLINICAL SURGERY    2025, 33 (1): 74-79.   DOI: 10.3969/j.issn.1005-6483.20241985
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Expert Consensus on Bone Repair Strategies for Osteoporotic Vertebral Compression Fractures
Orthopedic Expert Committee of Geriatrics Branch of Chinese Association of Gerontology and Geriatrics,Youth Osteoporosis Group of Chinese Orthopedic Association,Osteoporosis Group of Chinese Association of Orthopedic Surgeons,Osteoporosis Committee of Shanghai Association of Chinese Integrative Medicine.
JOURNAL OF CLINICAL SURGERY    2024, 32 (4): 442-448.   DOI: 10.3969/j.issn.1005-6483.2024.04.031
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Osteoporotic vertebral compression fractures is a common type of osteoporotic fractures,often occurring with minimal external force or even without obvious trauma.They manifest as pain,deformity,and functional impairment,significantly impacting patients’ quality of life.Following reduction of vertebral compression fractures,bone defects often occur and typically require bone grafting for repair.Surgical treatments primarily include percutaneous vertebral augmentation and open surgery.Cement augmentation,appropriate bone implantation,and anti-pullout internal fixation are crucial components of bone repair therapy.Different types of cement materials and novel vertebral augmentation techniques offer more options for vertebral fracture repair.This consensus incorporates epidemiological characteristics of osteoporotic vertebral compression fractures,referencing literature search results and expert survey opinions,to address common controversies regarding commonly used vertebral bone repair materials,strategies,and postoperative considerations in clinical practice.It is hoped that this consensus will improve treatment outcomes,enhance patient prognosis,and promote standardized clinical management of osteoporotic vertebral compression fracture repair.
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JOURNAL OF CLINICAL SURGERY    2024, 32 (1): 37-40.   DOI: 10.3969/j.issn.1005-6483.2024.01.010
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Research and clinical progress of immunotherapy for gastric cancer
HUANG Tao, WANG Anxin, FU Guang
JOURNAL OF CLINICAL SURGERY    2024, 32 (1): 99-102.   DOI: 10.3969/j.issn.1005-6483.2024.01.027
Abstract1013)      PDF(pc) (655KB)(1050)       Save
晚期胃癌治疗选择有限,易发生化疗耐药。目前,包括免疫检查点抑制剂、过继细胞疗法、肿瘤疫苗、非特异免疫增强剂及细胞因子疗法在内的免疫疗法对胃癌显示出了良好的疗效。载体药物及3D打印技术也在临床前实验中取得了疗效。临床试验采用免疫肿瘤学单一疗法或联合免疫化学疗法来提高胃癌病人的总体生存时间和客观反应率。根据初步证据,我们相信免疫治疗可以积极影响自然病史,改善胃癌病人的预后。
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The perioperative application of erector spinae plane block
LIN Daoyi,YE Peng,GONG Cansheng,WANG Danfeng,ZHENG Ting,ZHENG Xiaochun
JOURNAL OF CLINICAL SURGERY    2024, 32 (6): 657-660.   DOI: 10.3969/j.issn.1005-6483.2024.06.027
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The erector spinae plane block(ESPB) technique proposed by Forero et al.has drawn increasing attention due to its reliable effects and fewer complications in simple and safe procedures.It has been successfully applied in anesthesia management during the perioperative period.This article mainly introduces the anatomical basis,possible mechanism of action,common operating methods,and clinical applications during the perioperative period of ESPB.Starting from the advantages,disadvantages,and complications of ESPB,it compares ESPB with other common thoracolumbar analgesic methods,providing better evidence support for the perioperative application and future development of ESPB.
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Applications and advances of responsive neurostimulation in closed-loop epilepsy treatment
ZHANG Haocheng,LI Huaming,ZHU Junming,ZHANG Jianmin
JOURNAL OF CLINICAL SURGERY    2024, 32 (10): 1022-1025.   DOI: 10.3969/j.issn.1005-6483.2024.10.005
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JOURNAL OF CLINICAL SURGERY    2024, 32 (1): 31-33.   DOI: 10.3969/j.issn.1005-6483.2024.01.008
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Bibliometric analysis of related studies on nutrition in elderly patients with fracture in recent ten years
LIU Jing, WANG Huiwen
JOURNAL OF CLINICAL SURGERY    2024, 32 (8): 858-862.   DOI: 10.3969/j.issn.1005-6483.2024.08.020
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Objective  To analyze the current status,hot spots and future trends of nutrition related research in elderly fracture patients.Methods  Relevant literatures on nutrition in elderly patients with fracture in the core collection of web of science and CNKI were searched by computer from January 1,2013 to August 31,2023.and the search results were analyzed by using the software of CiteSpace,vision 6.2.R4.Results A total of 1 174 articles were included,including 366 Chinese articles and 808 English articles.In recent years,the number of literatures on nutrition related research of elderly fracture patients at home and abroad has shown an upward trend.The research hotspots abroad are hip fracture,bone mineral,vitamin D deficiency,bone mineral density,vitamin D,sarcopenia,proximal femur,population;Domestic research focuses on influencing factors,perioperative period,bone mineral density,nursing,osteoporosis,the elderly,tissue engineering,incision healing.Conclusion  Our country has certain advantages in the field of nutrition for elderly fracture patients,which can help researchers to understand the development trend,research hotspots and shortcomings of nutrition related to elderly fracture patients,and provide reference and guidance for future research.
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Application status and prospect of neurosurgical robot in implantable brain-computer interface
YIN Zixiao,YANG Anchao,ZHANG Jianguo
JOURNAL OF CLINICAL SURGERY    2024, 32 (10): 1013-1016.   DOI: 10.3969/j.issn.1005-6483.2024.10.002
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Deep brain stimulation and brain-computer interface technology:Interdisciplinary convergence of neuroscience, engineering, and clinical medicine
XIONG Botao,ZHANG Wei,WANG Wei
JOURNAL OF CLINICAL SURGERY    2024, 32 (10): 1019-1021.   DOI: 10.3969/j.issn.1005-6483.2024.10.004
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Progress in diagnosis and treatment of rectus abdominis separation
LIU Guozhong,LIN Youtuan,WENG Shangeng
JOURNAL OF CLINICAL SURGERY    2024, 32 (9): 990-993.   DOI: 10.3969/j.issn.1005-6483.2024.09.026
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Rectus abdominis diastasis (RAD) is a phenomenon in which the rectus abdominis muscles on both sides of the white line of the abdomen separate from each other,causing a series of physiological dysfunction.It is commonly seen in pregnant women and obese individuals.Currently,RAD has gradually attracted the attention of relevant surgeons.There is relatively little research on RAD both domestically and internationally,and there is no unified standard for diagnosis and treatment.This article will summarize the research progress on the diagnosis and treatment methods of rectus abdominis separation by combining domestic and foreign literature.
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Effects of clinical treatment decisions on long-term survival outcomes of locally advanced breast cancer with different molecular subtypes based on the SEER database
QIAN Fang*,SHEN Haoyuan,DENG Chunyan,SU Tingting,HU Chaohua,LIU Chenghao,XU Yuanbing,YANG Qingqing
JOURNAL OF CLINICAL SURGERY    2024, 32 (10): 1044-1049.   DOI: 10.3969/j.issn.1005-6483.2024.10.011
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Objective To explore the impact of clinical treatment decisions on the long-term survival of different molecular subtypes of locally advanced breast cancer(LABC),and to promote the development of more effective and individualized treatment regimens for LABC.Methods The cases of LABC diagnosed by pathology from 2010 to 2015 were searched in the database.Breast cancer-specific survival (BCSS) and overall survival (OS) were estimated by plotting Kaplan-Meier curves.The log rank test (Mantel-Cox) was used to analyze the difference between the groups,and the benefit population of LABC was determined after for age,TNM stage,grade,treatment methods.Results The 5-year OS and BCSS were 77.43% and 84.34% in breast-conserving,and 68.03% and 76.90% in mastectomy,respectively.The 5-year OS and BCSS of Luminal A LABC were 79.91% and 87.23% in breast-conserving,and 71.78% and 81.16% in mastectomy,respectively.The 5-year OS and BCSS of Luminal B LABC were 79.30% and 83.14% in breast-conserving,and were 70.37% and 76.92% in mastectomy,respectively.The 5-year OS and BCSS of triple-negative LABC were 60.77% and 68.13% in breast-conserving,and those of mastectomy were 47.13% and 55.94%,respectively.The 5-year OS and BCSS of HER2 positive were 75.42%,82.05% in breast-conserving,and were 67.05% and 75.01% in mastectomy,respectively;The 5-year OS and BCSS of triple-positive LABC were 86.12% and 91.63% in breast-conserving,and 74.54% and 82.56% in mastectomy,respectively.The 5-year OS and BCSS of well differentiated and N0 triple-positive LABC patients with chemotherapy were 88.24% and 76.91%,and those of patients without chmotherapy were 88.24% and 90.91%,respectively (BCSS:P=0.812;OS:P=0.311).Conclusion In the selective population,OS and BCSS of patients with LABC undergoing breast conserving surgery were significantly better than those of mastectomy.When OS and BCSS were compared for different molecular types and stages of LABC, breast-conserving surgery was still superior to total mastectomy.LABC could be considered for highly differentiated,N0 stage Triple positive without chemotherapy.
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Construction and verification of dynamic prognosis graph of gallbladder cancer patients
JIANG Zhiyang, CAN Haile, TANG Yafen, LI Xiaogang, LIAO Xiaofeng
JOURNAL OF CLINICAL SURGERY    2024, 32 (2): 182-187.   DOI: 10.3969/j.issn.1005-6483.2024.02.016
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Objective To construct a nomogram to predict the prognosis of patients with gallbladder cancer (GBC).Methods The clinicopathological data of GBC patients were extracted from the SEER database,and the independent prognostic factors of GBC patients were analyzed by Cox regression,and a nomogram was constructed.Finally,the column diagrams in the training queue and validation queue are verified.Results Age,T stage,M stage,histological grade,radiotherapy,surgery and tumor size were independent prognostic factors in GBC patients,and the differences were statistically significant (P<0.05).In the training cohort,the C index was 0.735 (95%CI=0.721~0.749),and the AUC values at 1,3 and 5 years were 0.821,0.820 and 0.833,respectively.In the verification group,the C index was 0.733 (95%CI=0.711~0.755),and the AUC values for 1,3 and 5 years were 0.816,0.807 and 0.827,respectively.The calibration curve shows that the predicted values of the nomogram are in good agreement with the observed values.The decision curve shows that the nomogram model has better prediction ability than TNM staging system.Conclusion The constructed dynamic prognosis nomogram of GBC patients has high accuracy and reliability.
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A multifactor Logistic analysis study on the compliance of ankle pump exercise
ZHANG Haiyan, LI Ronghua, CAO Xueqing, HE Juan
JOURNAL OF CLINICAL SURGERY    2024, 32 (7): 744-747.   DOI: 10.3969/j.issn.1005-6483.2024.07.020
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Objective To investigate the compliance status of ankle pump movement (APM) in high-risk patients with deep venous thrombosis (DVT) of the lower limbs and analysis the related influencing factors.Methods From January 2019 to March 2023,a total of 302 patients with high-risk lower limb DVT who admitted to our hospital were selected as the research objects.The APM compliance scale,clinical data sheet,visual analog scale (VAS),family support scale,self-efficacy scale,self-rating anxiety scale,and self-rating depression scale were used to evaluate the research subjects,and the evaluation results were analyzed.Results Among the 302 patients with high-risk DVT,171 patients had APM compliance,with a compliance rate of 56.62%.The results of univariate analysis showed that there were statistically significant differences in APM compliance among patients of different age groups,gender,education level,marital status,family economic income,work status,family support,medical insurance type,place of residence,reason for hospitalization,comorbidities,pain level,APM prescription time,self-efficacy,and psychological status (all P<0.05).The results of multivariate Logistic analysis showed that comorbidities (≥2 types),pain (moderate and above),and prescription time (≥ 7 d) were risk factors for APM compliance in DVT high-risk patients (all P<0.05),while education level (college or above),family support (moderate and above),and self-efficacy (moderate and above) were protective factors for APM compliance (all P<0.05).Conclusion The comorbidities,degree of pain,APM prescription time,educational level,family support,and patient self-efficacy can affect ankle pump compliance in high-risk patients with lower limb deep vein thrombosis,and should be given attention and targeted intervention.
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The quadrant method was used to assess the relationship between the type of cement distribution after vertebroplasty and new fractures of osteoporotic vertebral bodies
CHEN Li, LI Xueguang, ZHANG Dong, CAO Chuanjun
JOURNAL OF CLINICAL SURGERY    2024, 32 (2): 206-209.   DOI: 10.3969/j.issn.1005-6483.2024.02.022
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Objective  To evaluate the diffusion distribution of bone cement in the vertebral body by quadrant method,and to analyze and evaluate the correlation between the diffusion distribution type of bone cement and new vertebral fractures after vertebral augmentation.Methods  A total of 170 subjects who met the conditions from January 2020 to December 2021 were collected.According to the anteroposterior and lateral view of the spine,the injured vertebra was divided into four quadrants,and divided into homogeneous diffusion group and uneven diffusion group according to the postoperative diffusion distribution of bone cement in the injured vertebra.The incidence and types of refracture were followed up,and the VAS score and Cobb angle were compared between the two groups.Results 170 patients were followed up for at least 12 months,including 90 patients in homogeneous diffusion group and 80 patients in heterogeneous diffusion group.There were 33 cases of refracture(19.41%),12 cases of refracture(13.33%) in the diffuse homogeneous group,and 21 cases of refracture(26.25%) in the diffuse heterogeneous group,and the difference between the groups was statistically significant(P<0.05).The site of refracture in the diffuse homogeneous group was mainly the clinical vertebral fracture,while the probability of refracture in the diffuse heterogeneous clinical vertebra and the operated vertebra was similar.The incidence of postoperative bone cement leakage in the diffuse homogeneous group was significantly lower than that in diffuse heterogeneous group(P<0.05).The VAS score and Cobb angle were significantly improved in both groups after surgery and at the last follow-up compared with those before surgery,but there was no significant difference between groups.Conclusion The incidence of new vertebral fractures after vertebroplasty is closely related to the type of cement diffusion,and the risk of refracture defined as uneven cement diffusion by quadrant method is high.
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JOURNAL OF CLINICAL SURGERY    2024, 32 (1): 34-37.   DOI: 10.3969/j.issn.1005-6483.2024.01.009
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JOURNAL OF CLINICAL SURGERY    2024, 32 (1): 49-52.   DOI: 10.3969/j.issn.1005-6483.2024.01.013
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Interpretation of international guidelines for clinical diagnosis and treatment of BK polyomavirus infection in kidney transplant recipients (2nd edition)
ZHAO Guodong, HUANG Gang
JOURNAL OF CLINICAL SURGERY    2025, 33 (1): 63-66.   DOI: 10.3969/j.issn.1005-6483.20242003
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JOURNAL OF CLINICAL SURGERY    2023, 31 (9): 804-807.   DOI: 10.3969/j.issn.1005-6483.2023.09.002
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Clinical status and advances in targeted therapy for pancreatic cancer
GUO Keying, LI Shumin, CUI Jiujie
JOURNAL OF CLINICAL SURGERY    2024, 32 (7): 773-775.   DOI: 10.3969/j.issn.1005-6483.2024.07.028
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Pancreatic cancer has always been called the “king of cancer” due to its extremely high mortality.In recent years,the global incidence rate of pancreatic cancer has risen rapidly.Furthermore,pancreatic cancer is lack of effective therapeutic strategies and has seriously harmed human health.With the rapid development of precision therapy,targeted therapy for pancreatic cancer has also progressed rapidly.Although targeted therapy for pancreatic cancer has improved the prognosis of only a few patients,it has brought light to pancreatic cancer.This article reviews the research progress of therapeutic targets and related drugs for pancreatic cancer.
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Advances in the clinical application of biodegradable meshes in ventral hernia repair
ZHENG Ruotong,ZHAO Minxian,DI Zhishan,TONG Deyu,SHEN Yingmo
JOURNAL OF CLINICAL SURGERY    2024, 32 (9): 904-907.   DOI: 10.3969/j.issn.1005-6483.2024.09.003
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Neurosurgery and brain computer interface: Current situation and prospects
HU Feng,SHU Kai,LEI Ting
JOURNAL OF CLINICAL SURGERY    2024, 32 (10): 1009-1012.   DOI: 10.3969/j.issn.1005-6483.2024.10.001
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GUO Xinyi, Yu Yahong
JOURNAL OF CLINICAL SURGERY    2023, 31 (11): 1107-1110.   DOI: 10.3969/j.issn.1005-6483.2023.11.030
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Pancreatic cancer is a highly malignant tumor of the digestive system with poor prognosis.Due to the lack of effective early screening and diagnosis methods,the majority of patients with pancreatic cancer present with locally advanced or metastatic disease at diagnosis.For advanced pancreatic cancer,the major treatment strategy is still chemotherapy-based comprehensive treatment.The development of immunotherapy and targeted therapy gives us cause for optimism in our pursuit of better treatment.This article reviewed the advances in immunotherapy and targeted therapy of advanced pancreatic cancer.
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Research and application of cartilage organoids in cartilage repair
QIU Dewei, YANG Peng, TAO Jun
JOURNAL OF CLINICAL SURGERY    2025, 33 (4): 348-352.   DOI: 10.3969/j.issn.1005-6483.20250289
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In clinical research on articular cartilage injury repair,traditional treatment modalities can improve patients’ symptoms to a certain extent,but these approaches have limitations in long-term functional maintenance.In recent years,cartilage organoids (CORG) have drawn extensive attention due to their demonstrated potential advantages in the field of cartilage regeneration.This article aims to introduce the construction technology of CORG,providing a more promising application paradigm for cartilage repair.
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JOURNAL OF CLINICAL SURGERY    2023, 31 (10): 911-915.   DOI: 10.3969/j.issn.1005-6483.2023.10.004
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Postoperative adjuvant immunotherapy for huge hepatocellular carcinoma in China liver cancer staging Ⅲa
HUANG Hongwei,CHEN Qi,LIAO Wei,ZHANG Kaiyue,WANG Hao,MEI Bin
JOURNAL OF CLINICAL SURGERY    2024, 32 (4): 386-390.   DOI: 10.3969/j.issn.1005-6483.2024.04.017
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Objective The purpose of the study was to explore the clinical value of postoperative adjuvant immunotherapy for huge hepatocellular carcinoma (HCC) in China liver cancer staging (CNLC) Ⅲa.Methods Data of patients diagnosed as huge HCC in CNLC Ⅲa treated by liver resection at our center during June 2017 and July 2022 was retrospectively collected and divided into the treatment group and the control group according to whether underwent postoperative adjuvant treatment.48 cases included 20 cases in the treatment group while 28 cases in the control group were enrolled in this study.The endpoints of the study were recurrence-free survival (RFS) and overall survival (OS).Independent prognostic risk factors for OS and RFS were confirmed by Cox regression analysis.Results The median RFS in the treatment group compared to the control group was 6.8 vs. 2.8 months (P<0.05) and median OS was 17.2 vs. 7.2 months(P<0.05).The 1-year and 2-year RFS in the treatment group were 35.0% and 25.0% respectively while in the control group were 7.1% and 0.0%(P<0.05).The 1-year and 2-year OS in the treatment group were 65.0% and 30.0% respectively while in the control group were 42.9% and 14.3%(P<0.05).Multivariable analysis showed that preoperative aspartate transaminase (AST) >40U/L,multiple tumors and postoperative adjuvant immunotherapy were significant prognostic factors related to RFS while postoperative adjuvant immunotherapy and intraoperative blood transfusion were significant prognostic factors related to RFS.Conclusions Postoperative adjuvant immunotherapy can effectively improve the RFS and OS of huge HCC patients in CNLC Ⅲa.
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JOURNAL OF CLINICAL SURGERY    2023, 31 (12): 1124-1126.   DOI: 10.3969/j.issn.1005-6483.2023.12.004
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Efficacy and complications of one-step and two-step percutaneous transhepatic drainage in the treatment of advanced low-level biliary obstruction
GONG Jie, XU Zhenhua, LEI Zehua, GAO Fengwei, JIANG Kangyi, XIE Qingyun, ZHAO Xin
JOURNAL OF CLINICAL SURGERY    2024, 32 (7): 688-692.   DOI: 10.3969/j.issn.1005-6483.2024.07.006
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Objective To investigate the efficacy and complications of one-step and two-step ultrasound-guided percutaneous transhepatic hepatic duct drainage (PTHD) in the treatment of advanced low-level biliary obstruction.Methods A total of 112 patients with advanced low-level biliary obstruction who underwent palliative surgery for reducing jaundice in the hospital from January 2019 to July 2023 were selected,and divided into the one-step group and the two-step group according to the principle of complete randomization (grouped by random number table method).The one-step group (n=56) underwent one-step PTHD,while the two-step group (n=56) underwent two-step PTHD.Surgery related indicators,serum total bilirubin (TBIL),alkaline phosphatase (ALP),alanine transaminase (ALT),the incidence of postoperative complications,and satisfaction were compared between the two groups.Results There was no difference in intraoperative blood loss[(2.96±0.50)ml vs. (3.02±0.53)ml],drainage volume in 48 hours after surgery[(555.84±90.51)ml vs. (560.52±104.23)ml]between the two groups(P>0.05).Operation time and postoperative VAS score of the one-step group were significantly shorter/lower than those of the two-step group[(32.50±4.26) min vs. (36.43±3.58) min,(3.72±1.57) points vs.(4.53±1.34) points],and the success rate of puncture was significantly higher than that in the two-step group(96.43% vs.76.69%),with statistically significant differences (P<0.05).After treatment,the levels of TBIL,ALP and ALT in the two groups were significantly reduced (P<0.05),but there was no statistically significant difference between the groups (P>0.05).There was no statistically significant difference in the incidence of complications between the two groups (3.57% vs.7.14%,Fisher’s exact probability=0.679).The satisfaction rate in the one-step group was significantly higher than that in the two-step group (94.64% vs.75.00%),with a statistically significant difference (P<0.05).ConclusionThe operation time of one-step PTHD is shorter and the success rate of puncture is higher.In addition,patients undergoing one-step PTHD have milder pain,and are more satisfied.
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Predictive biomarkers of immunotherapy response in patients with hepatocellular carcinoma
DU Jiajia, HUANG Zhiyong
JOURNAL OF CLINICAL SURGERY    2023, 31 (10): 990-993.   DOI: 10.3969/j.issn.1005-6483.2023.10.024
Abstract289)      PDF(pc) (344KB)(454)       Save
Hepatocellular carcinoma (HCC) is a common malignant tumor.Patients often lose the opportunity for surgery because of the middle and late stage when they are diagnosed,and the prognosis is extremely poor.In recent years,anti-PD immunotherapy has made a breakthrough in the treatment of advanced liver cancer.Immunotherapy has achieved good results in some patients,but there are still many patients with poor response to immunotherapy.Therefore,there is an urgent need to find clinical or biological indicators that can be used to predict the efficacy of immunotherapy in order to maximize clinical benefits while avoiding adverse effects.This article aims to summarize the relevant indicators and potential predictive mechanisms that can be used to predict the efficacy of liver cancer immunotherapy,so as to provide help for guiding clinical treatment.
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Current status and development of clinical drug research for prostate cancer
LI Xian Miao, Yirixiatijiang·Amier, WU Huan Lei, HU Jia
JOURNAL OF CLINICAL SURGERY    2025, 33 (2): 204-207.   DOI: 10.3969/j.issn.1005-6483.20241929
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Prostate cancer is the most prevalent tumor of the urinary system globally and represents the highest incidence of malignant tumors among males in Europe and the United States.For recurrent or metastatic disease,androgen deprivation therapy is currently recognized as the cornerstone of treatment.However,nearly all patients inevitably progress to an incurable castration-resistant prostate cancer stage.Although the approval of several new drugs over the past two decades has enhanced both survival time and quality of life for patients with advanced prostate cancer,there remains an urgent challenge to develop new strategies that can overcome drug resistance and further extend survival duration.Therefore,based on published or ongoing clinical studies,this review will focus on an overview of the significant advancements made in the field of prostate cancer drug therapy,as well as new drugs that are actively undergoing clinical trials to provide a reference for the clinical treatment of advanced prostate cancer.
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JOURNAL OF CLINICAL SURGERY    2024, 32 (1): 55-57.   DOI: 10.3969/j.issn.1005-6483.2024.01.015
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Closed fracture-related soft tissue injury: classification and treatment
JIA Huiyang, ZHANG Heng, LIU Lin, GUO Jialiang, CHEN Wei, ZHANG Yingze, HOU ZHiyong
JOURNAL OF CLINICAL SURGERY    2024, 32 (4): 337-340.   DOI: 10.3969/j.issn.1005-6483.2024.04.001
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Expression of X-linked inhibitor of apoptosis associated factor 1 and phosphoenolpyruvate carboxykinase 1 in Luminal B breast cancer and their relationship with prognosis
YAN Pingping, ZHANG Shaodong, GUO Jiaoliang, DOU Yandong
JOURNAL OF CLINICAL SURGERY    2025, 33 (1): 97-101.   DOI: 10.3969/j.issn.1005-6483.20231669
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[Abstract] Objective To investigate the expression of X-linked inhibitor of apoptosis associated factor 1 (XAF1) and phosphoenolpyruvate carboxykinase 1 (PCK1) in Luminal type B breast cancer and their relationship with the prognosis of patients.Methods From January 2016 to January 2018, 95 patients with Luminal B breast cancer underwent surgical treatment. Cancer tissues and adjacent tissues > 5 cm from the cancer tissues were collected during the operation.The positive expressions of XAF1 and PCK1 proteins were detected by immunohistochemistry.The relationship between XAF1 and PCK1 protein expression and clinicopathological features of breast cancer was analyzed, and the survival curves of breast cancer patients with different XAF1 and PCK1 protein expression were plotted by KaplanMeier method,the survival rate was compared by Log-rankn test. Multi-factor Cox-regression analysis was used to analyze the prognostic factors of breast cancer.Results GEPIA database analysis showed that the expression levels of XAF1 and PCK1 mRNA in breast cancer tissues were lower than those in normal tissues ( P<0.05).The positive expression rates of XAF1 and PCK1 proteins in cancer tissue were lower than adjacent tissues ( P<0.05).The positive expression of XAF1 in breast cancer tissue was related to clinical stage,lymph node metastasis and histological grade,Ki-67 expression status,while the positive expression of PCK1 was related to clinical stage,lymph node metastasis and Ki-67 expression status ( P<0.05).The 5-year overall survival rate of XAF1 positive expression patients was higher than that of negative expression patients (Log-rank χ2=5.101, P=0.024),and the 5-year overall survival rate of PCK1 positive expression patients was higher than that of negative expression patients (Log-rank χ2=6.515, P=0.011).Clinical stage Ⅲ,negative expression of XAF1,and negative expression of PCK1 were risk factors for poor prognosis ( P<0.05).Conclusion The positive expression rates of XAF1 and PCK1 in Luminal B type breast cancer tissue are reduced,which is related to some clinicopathological characteristics and 5-year survival rate after surgery.The 5-year survival rate was lower in patients with negative XAFI and PCKI expression.
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JOURNAL OF CLINICAL SURGERY    2024, 32 (1): 17-21.   DOI: 10.3969/j.issn.1005-6483.2024.01.005
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2024 Interpretation of the International Transfusion Medicine Collaboration Guidelines for intravenous albumin
JI Guangwei
JOURNAL OF CLINICAL SURGERY    2025, 33 (1): 84-88.   DOI: 10.3969/j.issn.1005-6483.20241943
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Clinical effect of bedside fiberoptic bronchoscopy on patients with traumatic craniocerebral injury complicated with pulmonary infection and mechanical ventilation
ZHU Xinxin, LUO Jianjun, WANG Xiaoxia, JIANG Guangwei, WANG Lipeng, GUO Qifeng, MENG Wei, ZOU Chunxi, YANG Ruoruo, WU Shuqin, WU Qian
JOURNAL OF CLINICAL SURGERY    2023, 31 (9): 826-829.   DOI: 10.3969/j.issn.1005-6483.2023.09.008
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Objective To investigate the clinical effect of bedside fiberoptic bronchoscopy on patients with traumatic brain injury complicated with pulmonary infection undergoing mechanical ventilation. Methods From July 2018 to July 2022, 82 patients with traumatic craniocerebral injury complicated with pulmonary infection treated in our hospital were enrolled,42 patients with routine sputum aspiration were set as the control group,and 40 patients with bedside fiber bronchoscopy were set as the experimental group.Sputum samples were collected from both groups for examination and culture,and clinical data such as chest CT lesion absorption time,mechanical ventilation time,anti-infection course,ICU stay time were recorded.Driving pressure (△P),oxygenation index (OI),respiratory mechanical index and detection rate of effective pathogens were calculated.GOS-E score was followed up 6 months after injury. Results The total effective rate of the experimental group (95.00%) was higher than that of the control group (78.57%)(P<0.05).The ICU stay time,mechanical ventilation time,focus absorption time,driving pressure (△P),oxygenation index (OI),respiratory mechanics index and GOS-E score of the experimental group were significantly improved compared with the control group,and the differences were statistically significant (P<0.05). Conclusions  The implementation of bronchoscopy in ICU patients with traumatic craniocerebral injury and pulmonary infection can effectively improve pulmonary ventilation,lung dynamic compliance,and cerebral blood perfusion,which is helpful for clinical brain-lung conflict management and neurological prognosis.
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JOURNAL OF CLINICAL SURGERY    2024, 32 (1): 52-54.   DOI: 10.3969/j.issn.1005-6483.2024.01.014
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Management of Colorectal Cancer with Malignant Bowel Obstruction
CHENG Yifeng, ZHANG Weikang
JOURNAL OF CLINICAL SURGERY    2024, 32 (5): 457-460.   DOI: 10.3969/j.issn.1005-6483.2024.05.003
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A Meta-analysis on the outcome of Solid Hemangioblastomas treated by surgery combined with preoperative endovascular embolization
LI Xiangji, LIU Yanting, WAN Zhixian, ZHU Yuefeng, TIAN Chunlei
JOURNAL OF CLINICAL SURGERY    2023, 31 (12): 1130-1133.   DOI: 10.3969/j.issn.1005-6483.2023.12.006
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Objective To evaluate the clinical efficacy and safety of preoperative endovascular embolization of Solid Hemangioblastomas. Methods The data bases including Wan Fang,CNKI(China National Knowledge Infrastructure),VIP Database,PubMed、Medline、Springer were searched for the related studies.Two independent surgeons assessed trails for eligibility and quality,and all data marching the standards were abstracted for Meta-analysis by RevMan 5.3. Results 8 randomized controlled trails (RCT) were included.Selected analysis of embolized and non-embolized groups of Solid Hemangioblastomas were observed for variables of clinical efficacy in surgery time,number of blood loss and transfusions,complete resection,there were statistical difference.(P<0.000 01,WMD=-1.18, 95%CI[-1.16,-0.71];P<0.000 01,WMD=-464.17,95%CI[-492.17,-437.24];P<0.000 01, WMD=-238.81,95%CI[-282.84,-194.77];P<0.006,RR=1.17,95%CI[1.05,1.31]). Conclusion The preoperative endovascular embolization is beneficial for Hemangioblastomas because it can shorten the time of surgery,diminish the necessity of intra-operative blood loss and transfusion,it also raises the ratio of complete resection of Solid Hemangioblastomas.
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