Objective To investigate the clinical efficacy of minimally invasive mammotome biopsy,open surgery and puncture drainage in the treatment of plasmacytic mastitis at abscess stage.Methods A total of 90 patients with plasmacytic mastitis in abscess stage were selected and divided into three groups according to different treatment methods from January 2018 to July 2021:minimally invasive group (n=38),minimally invasive mammotome biopsy;In the open group,30 patients underwent conventional open surgery.In the puncture group,22 cases were treated with percutaneous puncture.The perioperative indicators,treatment effect satisfaction,and the recurrence rate after 1 year follow-up were compared and analyzed among the three groups. Results The operative time (17.92±4.44)min,incision length (0.37±0.06)cm,incision healing time (5.84±1.90)d and intraoperative blood loss (5.79±2.61)ml were shorter in the minimally invasive group than in the open group,and the differences were statistically significant (P<0.05).The satisfaction of treatment effect in minimally invasive group (89.47%) was better than that in open group (73.33%) and puncture group (54.55%),and the recurrence rate after 1 year follow-up in minimally invasive group (7.89%) was lower than that in open group (26.67%) and puncture group (36.36%),and the difference was statistically significant (P<0.05).Conclusion In view of the abscess period of plasma cell mastitis treatment,ultrasonic guided minimally invasive mammotome biopsy could easily be accepted by patients for its advantages,including small incision,small trauma,high patient satisfaction,short treatment period,high cure rate and beautiful appearance,the operation is simple and with a minimally invasive treatment,treatment effect is worth clinical promotion.

Objective  To investigate the clinical application and effect analysis of modified minimally invasive surgical approach(stereotactic aspiration + neuroendoscopy) in the treatment of spontaneous supratentorial intracerebral hemorrhage. Methods From 2019 to 2022,99 patients with spontaneous supratentorial intracerebral hemorrhage admitted by neurosurgery department of our hospital were selected and divided into modified minimally invasive surgical approach group(57 cases) and stereotactic aspiration group(42 cases) according to the operation mode.The basic data,preoperative hematoma volume,hematoma evacuation rate,catheterization time,postoperative edema zone diameter,postoperative rebleeding rate and Glasgow coma scale score of the two groups were statistically analyzed. Results Sex,age,admission blood pressure,preoperative Glasgow coma scale score and preoperative hematoma volume were not significantly different between the two groups.The postoperative hematoma evacuation rate and the Glasgow Coma Scale scores in the modified minimally invasive surgical approach group were higher than those of the stereotactic aspiration group.The catheterization time and the diameter of the edema band were less than that of the stereotactic aspiration group.Conclusion The modified minimally invasive surgical approach,combined with the advantages of rapid decompression by stereotactic aspiration,removal of hematoma and hemostasis under direct view of neuroendoscope,has certain advantages compared with single stereotactic aspiration.

Objective To investigate the clinical manifestations,imaging features,treatment strategies and outcome of head and neck lymphatic malformation (LM) in children.Methods The clinical data of 96 cases of head and neck LM confirmed by surgery or pathology from July 2014 to January 2022 were analyzed retrospectively.There were 2 cases of simple open surgery,10 cases of simple bleomycin injection,and 84 cases of open surgery combined with bleomycin.69 cases underwent one operation,15 cases underwent two operations,and 12 cases underwent three to eight operations.After admission,4 cases underwent endotracheal intubation and 3 cases underwent tracheotomy.Followed up for 3 ~ 93 months.Results There were 58 males and 38 females.The onset age ranged from 1 day to 14 years and 3 months,including 64 cases less than 2 years old,and 40 cases at birth.The lesions were located in 46 cases on the left,43 cases on the right and 7 cases on both sides;The lesions were located in the neck and parapharyngeal in 61 cases,in the head and face in 10 cases,and widely infiltrated in the head,face,neck or mediastinum in 25 cases;There were 91 cases of painless masses and 5 cases of inflammatory masses,including 28 cases of facial changes and 9 cases of dyspnea or dysphagia.There were 43 cases of intracapsular hemorrhage,and its contents were dark red or light bloody liquid.There were light yellow clear liquid or jelly like in 37 cases and water liquid in 16 cases.The positive rate of ultrasound diagnosis was 80.1% (70/87),and the positive rate of CT diagnosis was 91.8% (78/85).9 cases had transient facial paralysis,all returned to normal within 3 months,and 96 cases were cured.Conclusions Most of the head and neck LM occur within 2 years old.The clinical manifestation is often painless mass,mainly polycystic.The tumor body is often enlarged in a short time due to intracapsular hemorrhage.Ultrasound and CT reveal certain characteristic imaging findings,which can assist in diagnosis and treatment plan.Open surgery combined with bleomycin lavage will still be the main means of treatment in the future.

Objective To summarize the clinical experience of type A aortic dissection through ministernotomy and explore the safety and reliability of type A aortic dissection through ministernotomy.Methods Retrospective analysis of 471 patients with type A aortic dissection from June 2019 to Mar 2022(35 patients underwent ministernotomy,436patients underwent full sternotomy).Two cohorts including 35 patients in MS group and 70 patients in FS group were matched by tendency score matching,the baseline data and perioperative indicators were analyzed.35 ministernotomy operations include:24 cases of ascending and total arch replacement procedure; 8 cases of Bentall plus total arch replacement procedure; 3 cases of David procedure.Results All 35 cases of operation were successfully completed without transforming to full sternotomy; 1 case was treated by thoracotomy operation and hemostasis;2 cases with acute renal failure were treated by dialysis,All the patients had no complications of sternal opening after operation,and the incidence of pulmonary infection in the MS group was significantly lower than that in FS group.All the patients with ministernotomy were operated successfully and the patients recovered and discharged smoothly. Conclusion Aortic root ,ascending aorta and descending part of arch can be well exposed through ministernotomy,and did not significantly increase the time of operation,the risk of postoperative bleeding and the incidence of perioperative adverse events.

Objective To review the experience approaching middle mediastinal mass by surgery.Method  Clinical data of 9 patients with middle mediastinal mass who were treated in between 2018 to 2022 in Tongji hospital were retrospectively analyzed.8 cases underwent radical resection and 1 case underwent mediastinal tumor biopsy.5 mediastinal tumors were operated by video-assisted thoracoscopic surgery(VATS),and 4 cases required conversion thoracotomy. Result Histologic diagnosis was mediastinal cysts in 2 cases,Castleman disease in 1 case,metastatic lymphadenopathy in 1 case,neurogenic tumors in 3 cases(Schwannoma in 1 case,Neurofibroma in 1 case,and Paraganglioma in 1 case),angiolipoma in 1 case and undifferentiated malignant tumors in 1 case.All recovered and were discharged from hospital.Conclusion Surgical resection is an important treatment for mediastinal tumors. Surgical treatment should not only pursue the thoroughness of excision, but also pay attention to organ protection.

Objective To determinate the risk factors of postoperative pulmonary complications(PPCs) after hepatic resection for elderly patients and explore the precise perioperative managements. Method The clinical data of  114 elderly patients who underwent hepatectomy in our  hospital between January 2016 and December 2020 were collected.They were divided into PPCs group and control group according to occurrence of PPCs,and statistical analysis was conducted to explore the relevant factors that could affect the occurrence of postoperative pulmonary complications after liver resection in elderly patients.Results 114 elderly patients with liver resections were included.Postoperative pulmonary complications occurred in 36(31.6%,PPCs≥1) patients,including 1 ARDS,10 atelectasis,19 pleural effusions,and 26 pneumonias.Univariate analysis showed that PPCs were statistically different between the age of patients,smoking history,and pulmonary comorbidities before surgery,and were related to the type of liver resection,duration of surgery,and intraoperative blood loss(P＜0.05).Logistic regression analysis showed that the age of patients,smoking history,preoperative pulmonary comorbidities,operation duration and intraoperative blood loss were the independent risk factors for PPCs after hepatectomy in the elderly patients(P＜0.05). Conclusion Age,smoking history,preoperative pulmonary comorbidities,duration of operation,and intraoperative blood loss were the risk factors for pulmonary complications after hepatectomy in the elderly patients.Evaluation could help to select appropriate treatment and perioperative management for the elderly patients with hepatectomy.

Objective To explore the efficacy of imatinib combined with surgery in the treatment of middle-low rectal gastrointestinal stromal tumor (GIST).Methods From January 2005 to December 2021,18 patients with primary middle-low rectal GIST were diagnosed and treated in our hospital. Their gender,age,first symptoms,the size of the tumor and the distance from the lower edge of the tumor to the dentate line before and after the preoperative treatment,the effect of preoperative treatment,complete resection or not,anal preservation or not,postoperative complications,and short-term and long-term prognosis were analyzed. Results Among them,the first symptom was hematochezia in 6 cases (33.3%),diarrhea or constipation in 4 cases (22.2%),rectal tenesmus in 3 cases (16.7%),3 cases (16.7%) were found by physical examination,and abdominal pain in 2 case (11.1%). Before and after preoperative imatinib treatment,the maximum tumor diameter was (7.5±2.9)cm and (4.6±2.0) cm，respectively,and the difference was statistically significant (P<0.05). The distance between the inferior margin of the tumor and the dentate line before and after preoperative treatment was (3.2±1.5) cm and (4.3±1.5) cm,respectively (P<0.05). All patients achieved partial remission after preoperative treatment,and the median time to obtain the maximum therapeutic effect was 6 (3-10) months. All patients achieved R0 resection,and the anus preservation rate was 83.3% (15/18). There were no perioperative deaths in the whole group,and the postoperative hospital stay was (9.0±2.5) days. Complications occurred in 3 cases (16.7%) after surgery,and all recovered after conservative treatment. All the 18 patients continued to receive imatinib therapy after operation. The 1 year and 3 year relapse-free survival rates were 100.0% and 87.8%,respectively.Conclusions The preoperative treatment of imatinib is well tolerated in patients with middle-low rectal GIST,which is conducive to tumor downgrading,increasing the complete resection rate.

Objective To investigate the effect of apatinib combined with intraperitoneal hyperthermia and intravenous chemotherapy in the treatment of advanced gastric cancer with peritoneal metastasis.Methods The clinical data of 80 patients with advanced gastric cancer peritoneal metastasis admitted to the hospital from July 2017 to April 2021 were retrospectively analyzed.Among them,39 patients were given intraperitoneal hyperthermic perfusion and intravenous chemotherapy (referred to as the control group),and 41 patients were given apatinib combined with intraperitoneal hyperthermic perfusion and intravenous chemotherapy (referred to as the study group).The effect was evaluated were evaluated after 2 cycles of treatment in both groups.The patients were followed up for 1 year.The short-term efficacy,tumor markers,and drug safety of the two groups were compared,and the surgical resection,tumor regression,and survival during follow-up were compared between the two groups.Results The objective remission rate and clinical control rate in the study group were higher than those in the control group (P<0.05).After treatment,the levels of carcinoembryonic antigen (CEA) and Carbohydrate antigen 199 (CA199) in the two groups were decreased (P<0.05).The levels of CEA and CA199 were lower than control group after treatment(P<0.05).There was no significant difference in the incidence of leukopenia,neutropenia,fatigue,anemia,hand-foot syndrome and proteinuria between the two groups (P>0.05).The R0 resection rate in the study group was higher than that in the control group (P<0.05).The 1 year overall survival rate of study group was higher than control group (P<0.05).Conclusion Apatinib combined with intraperitoneal hyperthermic perfusion and intravenous chemotherapy has a significant curative effect in the treatment of advanced gastric cancer with peritoneal metastases and transformation.It can reduce the level of tumor markers,increase the R0 resection rate,improve TRG,and prolong the short-term survival rate of patients with good safety.

Objective To investigate the diagnostic value of neutrophil lymphocyte ratio(NLR),white blood cell count(WBC) and C-reactive protein(CRP) in children with complex appendicitis.Methods Children with acute appendicitis who were treated in our Hospital from January 2020 to December 2021 were divided into complex appendicitis group(120 cases in  used as the observation group) and simple appendicitis group(100 cases as the control group).The differences of gender,age,NLR,WBC and CRP between the two groups were compared.The influencing indexes of complex appendicitis were screened by univariate analysis,and the independent risk factors of complex appendicitis were screened by regression analysis.The receiver operating characteristic curve(ROC) was used to predict the diagnostic value of NLR,WBC and CRP indexes in children with complex appendicitis. Results Univariate analysis showed that NLR,WBC and CRP were the influencing factors of complex appendicitis;Multivariate analysis showed that NLR,WBC and CRP were independent risk factors for complex appendicitis.ROC analysis showed that the area under the curve(AUC) of NLR,WBC and CRP were 0.843 [95% CI:(0.791,0.894)],0.766 [95% CI:(0.704,0.827)],0.699 [95% CI:(0.631,0.767)];The AUC of NLR combined WBC,NLR combined CRP,NLR combined WBC and CRP were 0.869 [95% CI:(0.823,0.915)],0.888 [95% CI:(0.846,0.930)],0.902 [95% CI:(0.863,0.941)].Conclusion NLR,WBC and CRP have good predictive value in the diagnosis of complex appendicitis in children,and have important clinical reference significance.

Objective To investigate the application value of combined ultrasound and CT diagnosis of mesh infection after open inguinal hernia tensionless repair.Methods 83 patients admitted to our hospital with confirmed patch infection after tension-free repair of open inguinal hernia were studied,all of whom underwent preoperative ultrasound and abdominal CT examination,and intraoperative confirmation was the diagnostic criteria.To compare the value of ultrasonography, CT and combined examination in the diagnosis of mesh infection after open tension-free inguinal hernia repair. Results Among the 83 patients,the compliance rate of ultrasound diagnosis of mesh infection was 75.90%(63/83 cases);the compliance rate of CT diagnosis of mesh infection was 86.74%(72/83 cases);and the compliance rate of ultrasound combined with CT diagnosis of mesh infection was 87.95%(73/83 cases).The accuracy,sensitivity,specificity,and kappa values of ultrasound,CT,and ultrasound combined with CT in predicting the depth of mesh infection compared with the results confirmed during surgery were 88.76%,75.73%,90.58%,and 0.695;91.16%,80.96%,93.06%,and 0.774;and 91.97%,83.52%,93.64%,and 0.795.The combined examination was better than ultrasonography alone and CT alone in the diagnosis of postoperative mesh infection after open inguinal hernia repair(P<0.05). Conclusion Ultrasound combined with CT is better than ultrasound alone and CT alone in diagnosing mesh infection after open inguinal hernia repair without tension.

Objective To investigate the application of liquid-injection combined with gauze stripping in laparoscopic transperitoneal anterior inguinal hernia repair (TAPP). Methods A total of 164 consecutive patients with unilateral inguinal hernia from January 2019 to June 2020 were randomly grouped by the numerical table method and divided into a combined group of 81 patients who underwent laparoscopic liquid-injection combined with gauze stripping for preperitoneal repair and a simple group of 83 patients who underwent conventional TAPP.The operative time,patch size,postoperative complications and recurrence rate were compared between the two groups.Results Compared with the conventional procedure,patients in the fluid-injection combined with gauze stripping group had shorter operative time [(57.25±4.95)min vs.(66.69±8.69)min,P<0.001],larger patch size placement [(10.65±1.06)cm vs.(9.93±1.45)cm,P<0.001],and lower incidence of chronic postoperative pain in the inguinal region (1.2% vs.8.4%,P<0.05),and there were no infections or recurrences in either group at 12 to 24 months postoperative follow-up.Two patients in the simple group relapsed. Conclusion The use of fluid separation and gauze stripping in laparoscopic transepithelial anterior hernia repair is safe and feasible.

Objective To explore the independent risk factors of metastatic colorectal cancer(mCRC) combined with digestive tract perforation(DTP),and to construct the prediction model.Methods A total of 171 patients with mCRC treated in the hospital were enrolled between April 2018 and October 2021.According to presence or absence of DTP,they were divided into perforation group and non-perforation group.The data of patients were collected,including gender,age,types of primary tumors,history of smoking and drinking,diabetes mellitus,RAS/RAF status,colonoscopy,intestinal obstruction,anemia,diverticulum and usage of vascular endothelial growth factor(VEGF) inhibitors.The risk factors of mCRC combined with DTP were analyzed.The risk prediction model was constructed,and its predictive efficiency was analyzed. Results In the 171 patients with mCRC,there were 33 cases with DTP and 138 cases without,and the incidence of perforation was 19.30%.Colonoscopy,intestinal obstruction and usage of VEGF inhibitors were independent risk factors of mCRC combined with DTP(P＜0.05).The expression of risk prediction model was as follow:P=1/[1+e(-3.374+1.521×(colonoscopy)+1.418×(intestinal obstruction)+1.872×(usage of VEGF inhibitors)].The results of Hosmer-Lemeshow test were as follows:χ2=2.267,P=0.894.AUC and 95%CI of the model for predicting DTP were 0.734 and 0.724-0.859,showing good fit and predictive efficiency.Conclusion Multivariate Logistic regression model can better predict the occurrence of mCRC combined with DTP.Clinically,close attentions can be given for mCRC patients with aged ≥ 60 years,colonoscopy,intestinal obstruction and usage of VEGF inhibitors.

Objective To study the correlation between posterior urethral dilation and the severity and prognosis of posterior urethral valvular disease. Methods A total of 80 children with posterior urethral valve disease who were admitted to the pediatric surgery department of our hospital from January 2018 to December 2020 were selected.All the children underwent voiding cystourethrogram VCUG to measure the width of the urethra,and underwent transurethral cystoscopy for urethral valve electrotomy.Clinical data,urination,urine flow rate,residual urine,urinary tract infection,bladder morphology,hydronephrosis of kidney and ureter,vesicoureteral reflux,and renal function were compared between the two groups.Multivariate Logistic regression was used to analyze the correlation factors of postoperative prognosis of urethral valvular disease. Results Among the 80 patients included in the study,6 cases fell off,29 cases had poor prognosis and dysuria after operation,and were divided into the poor group,and the remaining 45 cases were divided into the control group,with the incidence of poor prognosis being 39.19%.The proportion of urethral dilatation length,urethral dilatation width,bladder wall thickening and trabecular hyperplasia and bladder dysfunction in the adverse group were higher than those in the control group(P＜0.05).Multivariate Logistic regression analysis showed that urethral dilation length(OR=8.880),urethral dilation width(OR=9.410),bladder wall thickening and trabecular hyperplasia(OR=5.375) were independent risk factors for the prognosis of posterior urethral valvular disease. Conclusion The length and width of urethral dilation,thickening of bladder wall and trabecular hyperplasia are the risk factors affecting the prognosis of urethral valvular disease.Early monitoring is helpful to understand the severity of urethral valvular disease and adjust the treatment plan.

Objective To compare the accuracy and surgical effect of ultrasound and CT guided rib fracture incision and reduction of internal fixation. Methods A total of 185 patients with chest trauma with multiple rib fractures admitted to the Department of Cardiothoracic Surgery Ningde Hospital affiliated to Ningde Normal University from January 2019 to December 2021 were collected.They were divided into control groups and observation groups according to different positioning methods.The control group performed routine CT reconstruction to determine the surgical incision.The observation group determined the surgical incision by high-frequency ultrasound.Patients in both groups underwent conventional incision reduction and internal fixation surgery.The incision accuracy,surgery-related indicators,VAS score and the overall treatment effect score were compared between the two groups.Results The Incision accuracy was 93.06% in the observation group and 88.37% in the control group,which was statistically significant(P<0.05).Observation group fracture exposure time(19.95±4.98)min,operation time(52.78±8.19)min,fracture healing time(43.70±3.21)d,drainage ball placement time(3.89±1.38)d,In the control group,the exposure time of fracture(28.47±5.64)min,operation time(65.61±10.72)min,fracture healing time(46.61±2.32)d and drainage ball placement time(5.17±2.01)d were statistically significant(P<0.05).VAS scores(4.72±1.67),GI scores(1.78±0.34),EI scores(1.23±0.32) in observation group 3 days after surgery,VAS scores(6.72±2.01),GI scores(2.61±0.45),EI scores(0.03±0.25) in control group 3 days after surgery,There was statistically significant(P<0.05).Conclusion As for rib fracture incision and reduction of internal fixation,Ultround-guided localization is better than CT and overall surgical treatment with ultrasound localization is better than CT.

Objective To observe the clinical effect of open wedge high tibial osteotomy(OWHTO) in the treatment of varus knee osteoarthritis and summarize treatment experience. Method 19 patients with varus knee osteoarthritis and treated by OWHTO in Wuhan Third Hospital between September 2018 and January 2021 were analyzed retrospectively.HSS score and VAS were used to evaluate the improvement of knee function and pain before and after operation.The correction effect of the surgery was evaluated by measuring MPTA and WBL.The scores and measured indicators at three time points of preoperation,3 months and 12 months after operation were compared.Results All patients were followed up for an average of(12±3) months.No internal fixation failure occurred during the follow-up.The HSS score at 3 months and 12 months after operation was significantly higher than that before operation(78.58±10.34，86.74±7.08，59.89±8.33，F＝47.66，P＜0.01),and the VAS at 3 months and 12 months after operation was significant lower than that before operation(2.47±0.61，1.32±0.58，6.47±0.77，F＝318.70，P＜0.01).For the imaging examination indexes,MPTA[(90.68±1.00)°，(90.37±1.01)°] and WBL[(60.53±1.73)%，(60.26±1.72)%] were improved and varus deformity was corrected at 3 month and 12 month after operation(P＜0.01).After 12 months of follow-up,the range of motion was significantly improved[(128.84±9.90 ）°vs (112.42±12.92)°，t=4.58，P＜0.01].Two cases of incision delayed healing,and the other incisions were primary healing without incision infection and bone infection.One patient had delayed union at the osteotomy site,and the bone union time was 6 months after operation.Intermuscular venous thrombosis of leg was occurred in two cases after operation and they recovered completely after comprehensive symptomatic treatment. Conclusion OWHTO could relieve joint pain and improve joint function by correcting the force line of lower limbs.It has excellent clinical effect on knee osteoarthritis with tibial varus,but it is necessary to grasp the surgical indications and pay attention to the details of the operation.

Objective To explore and evaluate the feasibility of ultrasound-guided improved dynamic needle tip positioning (DNTP) in infant arterial catheterization.Methods A total of 60 children aged from 1 month to 36 months who were admitted to our hospital from June 2022 to November 2022 and who needed artery puncture and catheterization were selected as subjects.They were randomly divided into two groups,namely DNTP group (D group) and improved DNTP group (G group),with 30 cases in each group.The depth of the radial artery was measured by ultrasound in both groups before operation.In the DNTP group,the depth of the radial artery was less than 2mm as the puncture point.In the improved DNTP group,the shallow radial artery depth was increased to 2-4mm by subcutaneous injection of normal saline under the guidance of ultrasound before puncture.The operation time of the two groups were recorded respectively,and the success rate of the first puncture,the total success rate,the time of the first puncture success,the total puncture time and the incidence of hematoma were compared between the two groups.Results The success rate of first puncture was 90.0% and the total success rate was 96.7% in group G,while 66.7% and 80.0% in group D.There were statistically significant differences between the two groups (P<0.05).The first successful time of group G was (135.2±12.2)s and the total puncture time was (165.3±38.5)s,which was significantly shorter than the first successful time of group D (227.4±23.3)s and the total puncture time of group D (258.3±45.1)s,and the difference was statistically significant (P<0.05).There were 1 case of failure of radial artery puncture caused by local hematoma in group G,and 6 cases of failure of radial artery puncture caused by vasospasm and local hematoma in group D,with statistical significance between the two groups (P<0.05).Ultrasound-guided puncture was successful after changing the puncture site.Conclusion During radial artery catheterization in infants and young children,the ultrasound-guided modified dynamic needle tip positioning technique by subcutaneous injection of normal saline can significantly improve the success rate of puncture,shorten the puncture time and reduce the complications related to puncture.

Objective To investigate the clinical effect of autologous platelet-rich plasma(PRP) gel technique in the treatment of large area skin defect wounds with reticular skin grafting. Methods From January 2018 to December 2019,39 patients who met the inclusion criteria and needed skin grafting on large wound surface were included in the control group,a total of 41 patients who met the inclusion criteria and required skin grafting from January 2020 to December 2021 were into the Study Group.The patients in both groups were made into a large mesh skin graft by taking the medial thigh skin with an electric skin knife,while the patients in the observation group were smeared on the inner surface of the mesh skin with autologous platelet-rich plasma gel,and the patients in the control group were wetted with normal saline,the pressure bandage was removed at 7 days after operation,and the dressing was changed at 10 days and 13 days after operation.The healing rate of skin graft was calculated on the 7th,10th and 13th day after operation,and the pain degree was evaluated by visual analogue scale(VAS) at the 1st and 2nd week after operation Vancouver scar scale(VSS) was used to evaluate the degree of scar hyperplasia at the 1st and 2nd month,and the adverse reactions were observed during the treatment. Results On the 7th,10th and 13th day after operation,the healing rates of the skin graft in the observation group were(51.1±9.8)%,(79.3±7.8)% and(95.5±3.5)% respectively,while those in the control group were(45.5±9.1)%,(67.8±8.1)% and(86.3±5.7)% respectively,the healing rate of skin graft in the observation group was significantly higher than that in the control group(P＜0.05),and the pain VAS scores were(3.1±1.2) and(1.1±0.3) at the 1st and 2nd week after operation in the Observation Group,respectively,the VAS scores of the control group were(4.0±1.4) and(1.7±0.5)，respectively.The pain scores of the observation group were significantly lower than those of the control group(P＜0.05),The VSS scores of hypertrophic scar in the observation group were(7.1±1.9) and(3.3±1.1) at the 1st and 2nd month after wound healing respectively,and those of the control group were(9.3±2.1) and(4.7±1.5) respectively,the scores of scar hyperplasia in the Observation Group were significantly lower than those in the control group(P＜0.05),the adverse reaction rate in the observation group was 7.3%,the adverse reaction rate in the control group was 23%,the incidence of adverse reactions in the observation group was significantly lower than that in the control group(P＜0.05).Conclusion Autologous platelet-rich plasma gel can promote the skin growth of mesh skin grafting wound,shorten the healing time,reduce the degree of pain,reduce scar hyperplasia,and reduce the incidence of adverse reactions.