Objective To investigate the effect of early cranioplasty after decompressive craniectomy(DC) for patients with traumatic brain injury(STBI) and influence on cerebral hemodynamics.
Methods 124 STBI patients after DC operation were collected and randomly divided into two groups:observation group(n=59) underwent early cranioplasty(1 to 3 months after DC operation),and control group(n=65) underwent late cranioplasty(3 to 6 months after DC operation).The postoperative complications,the National Institutes of Health Stroke Scale(NIHSS) score,Barthel Index(BI) and Glasgow Outcome Scale(GOS) score were compared between the two groups.The average blood flow velocity(Vm) of the middle cerebral artery(MCA),the regional cerebral blood flow(CBF),cerebral blood volume(CBV),time to peak(TTP),and mean transit time(MTT) in the cerebral cortex,basal ganglia and thalamus were measured before and 14 days after surgery.
Results 14 days after the surgery,the Vm of MCA at injured side and uninjured side of the observation group was(70.13±9.25)cm/s and(69.45±9.96)cm/s,the control groups was(66.17±7.82)cm/s and(67.86±9.63)cm/s,both groups were significantly higher than before surgery,and the Vm at injured side of the observation group was significantly higher than that of the control group(P＜0.05).At 14 days after surgery,the changes of CBF in the cerebral cortex,basal ganglia and thalamus in the observation group was(29.88±6.32),(8.87±2.61) and(7.61±1.64) [ml/(100 g·min)],both higher than(19.84±5.13),(4.15±1.15) and(5.37±1.52) [ml/(100 g·min)] in the control group(P＜0.05);the changes of CBV in the cerebral cortex,basal ganglia and thalamus in the observation group were(3.81±0.64)ml/100g and(1.11±0.33)ml/100g,which were higher than(1.62±0.52)ml/100g and(0.47±0.15)ml/100g in the control group(P＜0.05);the changes of TTP values in the cerebral cortex and basal ganglia of the observation group were -(5.22±1.06)s and -(3.50±0.56)s,which were higher than the control group[-(2.78±0.85)s and-(1.99±0.51)s](P＜0.05),but the difference in MTT changes between the two groups was not significant(P>0.05).At 3 months after surgery,the NIHSS score of the observation group was(3.73±0.56) points,which was significantly lower than(4.02±0.71) points of the control group(P＜0.05).The BI and GOS scores were(85.83±6.79) points and(4.05±0.45) points,respectively,which were significantly higher than(80.12±6.14) points and(3.72±0.41) points of the control group(P＜0.05).The excellent rate of prognosis of the observation group was 88.14%,which was significantly higher than 75.38% of the control group(P＜0.05).The postoperative complication rate of the observation group was 8.47%,there was no statistically significant difference compared with 10.77% of the control group(P>0.05).
Conclusion Early cranioplasty after DC for STBI patients is beneficial to improve cerebral hemodynamics,promote the recovery of nerve function and improve clinical prognosis.

Objective To investigate the expression and clinical significance of ubiquitin C-terminal hydrolase L1(UCH-L1) and neurofilament light chain polypeptide(NF-L) in serum exosomes of patients with acute moderate and severe traumatic brain injury(TBI).
Methods 94 patients with moderate to severe TBI in our Hospital from January 2017 to August 2020 were selected as the observation group,and 52 healthy people in the same period were selected as the control group.At 2 hours,12 hours,24 hours,48 hours and 72 hours after injury,5 ml of peripheral blood was collected to extract exosomes.The concentrations of UCH-L1 and NF-L in exosomes were detected by enzyme-linked immunosorbent assay(ELISA).
Results The concentration of UCH-L1 protein in the peripheral blood of the observation group reached the peak at 12 hours,and then gradually decreased,but it was significantly higher than the corresponding value of the control group at each time point,and the concentration of NF-L protein gradually increased,with significant difference compared with the control group(P<0.05).The protein concentrations of UCH-L1 and NF-L were not correlated with age,gender and whether brain edema was present.UCH-L1 was not correlated with diffuse axonal lesion or focal axonal lesion,but NF-L could well distinguish diffuse axonal lesion from focal axonal lesion(P<0.05).In the patients who died within one week after admission,the concentration of UCH-L1 protein in exosomes increased continuously,and there was a significant difference compared with the patients who did not die(P<0.05).
Conclusion In the early stage of moderate and severe TBI,the levels of UCH-L1 and NF-L in peripheral blood exosomes were significantly increased;NF-L can distinguish diffuse or focal axonal injury,and UCH-L1 can predict the early mortality.The exosomes UCH-L1 and NF-L may be ideal biomarkers for TBI to predict disease severity and prognosis.

Objective To investigate the clinical efficacy and safety of precise positioning neuroendoscopy in the treatment of intraventricular hemorrhage.
Method 82 patients with intraventricular hemorrhage admitted to the neurosurgery department of Hanzhong Central Hospital and the neurosurgery department of Xiangyang first people's Hospital from April 2018 to December 2019 were selected and divided into endoscopic group and drainage group.The endoscopic group was treated with precise positioning neuroendoscopic minimally invasive surgery(n=41 cases),while the drainage group was treated with traditional extraventricular puncture and drainage(n=41 cases).The indwelling time of drainage tube,hospital stay,hematoma clearance rate after 48 hours,complications,death and inflammatory factor levels were compared between the two groups.
Results Compared with the drainage group,the clearance rate of hematoma 48 hours after operation in the endoscopic group was higher[(91.24±4.94)% vs (81.21±4.73)%](P<0.05).The indwelling time[(3.54±0.93）d vs（4.27±1.06）d] and hospitalization time[(10.34±1.97)d vs (15.49±2.28)d] of drainage tube were less,and the postoperative complications（4.88%vs 19.51%） were less(P<0.05).
Conclusion Accurate positioning neuroendoscopy is effective and safe in the treatment of ventricular hypertensive hemorrhage.

Objective To compare the efficacy and safety of the partial hemilaminectomy approach and the classic hemilaminectomy approach.
Methods A total of 55 patients with intraspinal schwannoma who underwent partial hemilaminectomy from November 2016 to January 2019 in First Affiliated Hospital of Chongqing Medical University were collected as the research group,and 61 patients with intraspinal schwannoma at the same period who treated with classic hemilaminectomy served as a control group.The differences in tumor total resection rate,surgical incision length,postoperative incision infection rate,intraoperative blood loss,operation time,postoperative VAS pain score,postoperative motor sensory evaluation,and incidence of spinal deformity were compared and analyzed between the two groups.
Results There was no significant difference between the two groups in tumor total resection rate,postoperative spinal deformity rate,postoperative movement sensory improvement rate(P>0.05);the VAS scores of the research group at 24 h and 48 h were significantly lower than those of the control group(P<0.05).Compared with the control group,cases in the research group had small surgical incisions,low postoperative incision infection rate,less intraoperative blood loss,and short operation time,with significant differences(P<0.05).
Conclusion Treatment of intraspinal schwannoma via partial hemilaminar approach has less trauma,low surgical risk,and does not increase the incidence of early or late period postoperative complications,does not affect the tumor total resection rate.

Objective To summarize the clinical characteristics of patients diagnosed with hypertrophic obstructive cardiomyopathy and analyze the therapeutic outcomes after septal myectomy in our center.
Methods From June 2018 to July 2021,there were 27 patients diagnosed with hypertrophic obstructive cardiomyopathy received septal myectomy in our center.Their demographic data,clinical characteristics,received surgical techniques,and therapeutic outcomes were retrospectively analyzed.
Results 14 patients recovered to no or mild mitral regurgitation after operation.Peak pressure gradient of left ventricle outflow tract was decreased from preoperative (65.9±47.5)mmHg to postoperative （13.8±10.2）mmHg,and the thickness of interventricular septum was decreased from preoperative （22.2±7.3）mm to postoperative （15.9±6.3）mm.The symptoms were improved after operation,with 25 patients recovered to class Ⅰ or Ⅱ heart failure of New York Hear Association.There were no conduction block,ventricular septal perforation or perioperative death occurred among these patients.
Conclusion Septal myectomy remains the gold standard for the treatment of hypertrophic obstructive cardiomyopathy.The mitral valve apparatus should be carefully inspected before and during operation.Most mitral regurgitation would recover upon thorough septal myectomy.Mitral valvuloplasty or mitral valve replacement would frequently unnecessary for mitral valve without intrinsic diseases.

Objective To analyze the independent factors of discharge within 24 hours after operation of hiatal hernia and to construct a scoring model to predict discharge within 24 hours.
Methods The clinical data of 32 patients with hiatal hernia in Xijing Hospital from October 2017 to October 2019 were retrospectively analyzed,and the independent risk factors affecting discharge 24 hours after operation were analyzed.According to the weight of risk factors,a scoring model was constructed to predict discharge 24 hours after hiatal hernia operation.
Results In all 32 patients with hiatal hernia,13(40.8%) were discharged within 24 hours after operation.The surgeon with experience on day surgery and the time of operation were independent risk factors of discharge within 24 hours after operation.The prediction model was constructed based on these two factors.When the model score exceeded 1.408,the case was discharged within 24 hours after operation.The positive prediction rate was 1.000(95%CI:0.735-1.000),whereas the negative prediction rate was 0.950(95%CI：0.751-0.999).Predicted model AUC 0.992(95%CI:0.973-1.000),sensitivity0.923(95%CI:0.640-0.998),specificity1.000(95%CI:0.823-1.000),accuracy0.969(95%CI:0.838-0.999).The clinical decision curve shows that the use of this prediction model has significant clinical benefits under any risk probability.
Conclusion A scoring model based on surgeon with experience on day surgery and operation time can accurately predict the possibility of discharge within 24 hours after operation.

Objective To exlpore the expression and clinical of Glycine methyltransferase(Glycine N-methyltransferase,GNMT) in lung cancer and adjacent tissues.
Methods 140 patients' cancer and adjacent tissues were selected,RT - qPCR and Western blot method were used to detect GNMT mRNA and protein expression in these tissues.The correlation of GNMT expression with gender,age,smoking history,tumor size,lymph node metastasis,TNM stage and long-term survival rate was analyzed.
Results The GNMT mRNA and protein expression in cancer tissues was higher than that in cancerous tissue(P<0.05).There was no significant correlation among GNMT expression and gender,age,smoking history(P>0.05),but there was negative correlation among the tumor size,lymph node metastasis and TNM staging(P<0.05).GNMT expression was higher,the longer patients postoperative survival time.The median survival was 34 months in the patients with low GNMT expression,but the medium survival in the patients with high GNMT expression was 45 months.
Conclusion GNMT could suppress the development of lung cancer,the prognosis of patients with high expression of GNMT is better.

Objective To compare the clinical effect of lobectomy and sublobar lobectomy on pulmonary function and recurrence in elderly patients with NSCLC.
Methods 164 elderly patients with lung cancer from January 2014 to December 2015 in our hospital were analyzed,included 68 patients with sublobar lobectomy(A group),96 patients with lobectomy(B group).The duration of operation,intraoperative blood loss,thoracic drainage time,lung function,postoperative recurrence rate were observed and compared.
Results The duration of operation,intraoperative blood loss,thoracic drainage time and drainage volume of patients in A group were(140.83±32.17) min,(78.45±25.64) ml,(5.18±1.17) min,(786.31±157.42) ml,which were less than B group(P<0.05).And after surgery 3 d,the force vital capacity(FVC),forced expiratory volume in one second(FEV1),FEV1%pre,peak expiratory flow(PEF) of patients in A group were higher than B group(P<0.05).There was no difference on complications and postoperative 3-year recurrence rate between two groups(35.29% vs.25.0%)(P>0.05).
Conclusion The recurrence rate of sublobectomy is similar to that of lobectomy,but the complication rate of sublobectomy is lower and the pulmonary function would be less affected in elderly patients with early NSCLC.

Objective To investigate the expression of microrna-451 in serum of patients with papillary thyroid carcinoma and its diagnostic significance.
Methods Thirty-six patients with papillary thyroid carcinoma were selected as the study group,and thirty-seven patients with benign thyroid tumor were selected as the control group.The relative expression of serum microrna-451 in the two groups was detected by real-time fluorescent quantitative PCR.The expression difference of serum microrna-451 between the two groups was compared,and the relationship between the expression of serum microrna-451 and different clinicopathological features in patients with papillary thyroid carcinoma was analyzed.The diagnostic value of serum microrna-451 in papillary thyroid carcinoma was analyzed by curve analysis.
Results The expression of serum microrna-451 in patients with papillary thyroid carcinoma was significantly lower than that in patients with benign thyroid tumor(1.09±0.27 vs 1.31±0.23);The expression of serum microrna-451 in patients with lymph node metastasis of papillary thyroid carcinoma was significantly lower than that in patients without lymph node metastasis(0.92±0.17 vs 1.28±0.22，P<0.001),the differences were statistically significant;By ROC curve analysis,the AUC of serum microrna-451 in the diagnosis of papillary thyroid carcinoma was 0.720,and 0.873 in the diagnosis of lymph node metastasis.
Conclusion The expression of microrna-451 in serum of patients with papillary thyroid carcinoma is low,especially in patients with lymph node metastasis,which indicates that it has certain diagnostic significance for preoperative diagnosis and lymph node metastasis of papillary thyroid carcinoma.

Objective To detect the level of Chemokine(C-C motif) ligand 22(CCL22) expression level in serum of gastric cancer,and analyze its relationship with the development of gastric.
Methods Fifty-five gastric patients and 30 healthy controls were enrolled in the present study.Peripheral blood of gastric cancer patients and healthy controls was collected,respectively.Total RNA in PBMCs was extracted by TRIzol.Then RNA was reversely transcribed into cDNA by reverse transcription PCR.CCL22 mRNA level in PBMCs was assayed by real-time PCR method.CCL22 protein level in serum was detected by ELSIA.Migration assay was used to evaluate the chemotactic effect of CCL22 on gastric cancer cells.
Results CCL22 RNA expression level in serum of gastric cancer patients was higher than that in healthy controls(P<0.05).CCL22 protein expression level in serum of gastric cancer patients was (1401.67±481.12)pg/ml,which was significantly higher than that in healthy controls[(500.08±100.51)pg/ml](P<0.05).Furthermore,the increase of CCL22 protein expression level in serum was in accordance with the clinical stage of gastric cancer.CCL22 could induce the migration of gastric cancer cells in a dose-dependent manner.
Conclusion Serum CCL22 expression in gastric cancer patients was increased.CCL22 had a chemotactic effect on gastric cancer cells.We  think that CCL22 might be involved in the development of gastric cancer.

Objective To study the effects of less invasive stabilization system(LISS) plate combined with minimally invasive percutaneous plate osteosynthesis(MIPPO) technique and open reduction and internal fixation on perioperative indexes and postoperative joint function recovery in patients with tibiofibular fractures.
Methods Totally 92 patients with tibiofibular fractures in our hospital between October 2016 and October 2019 were divided into two groups by random number table method,with 46 cases in each group.Observation group was treated with LISS plate combined with MIPPO technique,and control group was given open reduction and internal fixation.The perioperative indexes,stress indicators,joint function and complications were compared between the two groups.
Results The surgical time,incision size,intraoperative blood loss,hospital stay and fracture healing time in observation group were shorter or less than those in control group(P<0.05).On the 1st d and 7th d after surgery,the levels of serum PGE2,Cor and NE in the two groups were significantly increased(P<0.05),and the levels on the 7th d after surgery were significantly lower than those on the 1st d after surgery(P<0.05),and the levels of serum PGE2,Cor and NE in observation group were lower than those in control group on the 1st d after surgery(P<0.05).The excellent and good rates of joint function in the two groups were 82.61% and 63.04% at 3 months after surgery(P<0.05).The excellent and good rates of joint function in the two groups at 12 months after surgery were 93.48% and 86.96% respectively(P>0.05).The incidence rates of complications were 13.04% and 30.43% in the two groups。respectively(P<0.05).
Conclusion LISS plate combined with MIPPO technique has obvious minimally invasive advantages in the treatment of tibiofibular fractures,and it is beneficial to promote fracture healing and joint function recovery and reduce the surgical complications.

Objective To investigate the effect of enhanced recovery after surgery(ERAS) in the perioperative period of elderly hip fracture patients.
Methods 70 patients with elderly hip fracture patients admitted from June 2017 to June 2019 were divided into control group(35 patients) and ERAS group(35 patients) according to a retrospective study.During the perioperative period of elderly,the patients of ERAS group received ERAS management,while the patients of control group were given routine recovery management hip fracture patients.Visual analogue scale(VAS) were used to assess the pain scale of patients.The length of hospital stay and hip Harris score were compared between the two groups.The postoperative complications including deep vein thrombosis,urinary tract infection,nausea and vomiting,pulmonary infection,incisional infection,and constipation were compared between the two groups.
Results Compared to the control group,the length of stay in the ERAS group was significantly less than that of the control patients(P＜0.05).VAS scores at 1,3,and 7 days postoperative of ERAS group were significantly lower than that of patients in the control group(P＜0.05).The incidence of perioperative complications was also significantly lower in the ERAS group compared with control group(P＜0.05).
Conclusion ERAS can promote postoperative rehabilitation and reduce the occurrence of postoperative complications in elderly hip fracture patients.

Objective To analyze the clinical effect of core decompression combined with allogeneic bone grafting or artificial lamina implantation in the treatment of femoral head necrosis and hip joint preservation.
Methods Eighty patients with femoral head necrosis admitted to our hospital from January 2018 to December 2019 were divided into group A and group B;group A was treated with core decompression combined with allograft,and group B was treated Core decompression combined with artificial lamina implantation;HHS and VAS scoring systems were used to evaluate patients before and after treatment,and the success rate of patients’ treatment was evaluated.The patients were examined by X-ray before treatment and during follow-up,and the imaging changes were evaluated according to Arco staging.
Results After treatment,the HHS score of group A(84.83±2.18) and group B(89.49±2.39) were higher than those of before the treatment of group A(57.11±8.32) and group B(56.38±7.97)(P<0.05).After treatment,the HHS score of group B(89.49±2.39) was significantly higher than that of group A(84.83±2.18)(P<0.05);the VAS score of group A(4.65±1.03)  were significantly higher than those of  before the treatment of group A(6.55±2.18)(P<0.05).After treatment,the VAS score of group B(3.02±0.87) was significantly lower than that of  before the treatment of group B(6.47±1.95)(P<0.05).After treatment,the VAS score of group B(3.02±0.87) was significantly lower than that of group A(P<0.05).The treatment success rate of group B(97.50%) was significantly higher than that of group A(80.00%)(P<0.05).
Conclusion Compared with core decompression combined with allogeneic bone transplantation,core decompression with artificial lamina implantation can more effectively improve hip joint function in patients with femoral head necrosis and improve clinical efficacy.

Objective To explore the effect of Internet + self-management program on the quality of life of in patients with bladder cancer undergoing ileum cystostomy during the continuance period.
Methods In this study,non-contemporaneous controlled tests used.Sixty-three patients with bladder cancer who underwent ileostomy in the urological ward of a third-grade a general hospital in Chengdu selected as the study subjects.Patients who met the criteria for admission from March 2019 to September 2019 assigned to the control group,and those who met the criteria for admission from October 2019 to April 2020 assigned to the intervention group.Patients in the control group received routine nursing measures during hospitalization,and received routine telephone guidance at 4th week after discharge.In addition to conventional nursing measures,patients in the intervention group also received Internet + self-management mode during hospitalization and 4 weeks after discharge.They followed up by telephone every week to receive periodic answers and personalized and positive motivational guidance.If patients raised questions and gave answers,the research group increased the number of telephone visits and followed up the results.General data questionnaire,Stoma-QOL and Out-of-hospital Complications Record table used for data collection.
Results The total quality of life score of the intervention group 4 weeks after discharge was significantly higher than that of the control group,and the difference between the scores of the two groups was statistically significant(P<0.05).Four weeks after discharge,the scores of sleep,relationship with family(friends) and other social relationships with non-family(non-close friends) in the intervention group were better than those in the control group,and the differences between the two groups were statistically significant(P<0.05).There was no significant difference in the scores of sexual life between the two groups(P>0.05).Four weeks after discharge,the number of complications in the intervention group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).There were 3 cases of peridermatitis of stoma in the intervention group and 11 cases in the control group,and the differences between the two groups were statistically significant(P<0.05).There was no significant difference in the incidence of urinary tract infection,ureteral stent detached,and stoma bleeding g(P>0.05).
Conclusion The application of the Internet + self-management program can effectively improve the quality of life of patients with bladder cancer undergoing ileocystostomy and reduce the occurrence of complications.

Objective To investigate starting early solifenacin treatment in patients with high preoperative OABSS after transurethral resection of the prostate(TURP) would be reasonable.
Methods A total of 127patients(OABSS score>5) undergoing TURP were prospectively evaluated and divided into two groups according to their OABSS.Those with a score of ≥11 points were Group 1(G1),and those with ≤10 points Group 2(G2).In addition,patients in each group were randomly further divided into two subgroups:those who were started on 5 mg solifenacin succinate in the earlypostoperative period(G1A/G2 A) and those who were not(G1B/G2B).
Results Preoperative OABSS score:G1A group 11.63±1.149,G1B group 12.43±1.165,G2A group 6.41±1.142,G2B group 6.30±1.311;OABSS score in three months after operation:G1A group 5.26±1.196,G1B group 7.63±2.092,G2A Group 5.57±2.940,G2B group 4.55±2.862;G1 group and G2 group three months after the OABSS score comparison P=0.007(P<0.05);G1A and G1B comparison P<0.001,G2A and G2B comparison P=0.138(P>0.05).
Conclusion Solifenacin succinate treatment in the early postoperative period may be beneficial for patients with high preoperative OABSS.

To investigate the prognostic factors of primary hepatic angiosarcoma(PHA).
Methods We extracted 290 PHA cases between 1975 and 2016 from the Surveillance,Epidemiology and End Results database and performed survival analyses on the baseline characteristics.
Results Age≥70 years old,tumor size >85 mm,male,distant metastasis,no primary site surgery(PSS) and no chemotherapy were independent risk factors of PHA patients' prognosis(P<0.05).There was a survival difference between chemotherapy and no chemotherapy in patients who were distant metastasis with PSS,no metastasis without PSS,local metastasis without PSS and distant metastasis without PSS,respectively(P<0.05).
Conclusion PHA was rare with a poor prognosis and mainly occurred in elderly males.Early detection and diagnosis could improve survival rate.PSS and chemotherapy could improve prognosis,but patients who underwent PSS without distant metastasis might not benefit from chemotherapy.

Objective To investigate the effects of Sevoflurane on proliferation,apoptosis,invasion and migration,glycolysis and expression of BACE1 antisense RNA(BACE1-AS) in hepatocellular carcinoma(HCC)cells.
Methods HCC cells were cultured and treated with 4% Sevoflurane.The Cancer Genome Atlas(TCGA) was used to mine the relevant biological information of BACE1-AS,including expression in HCC tissue,prognosis correlation analysis and so on.
Results Our date showed that Sevoflurane significantly decreased the survival rate of HepG2 cells(P＜0.05).In addition,Sevoflurane was an effective pro-apoptotic factor(P＜0.05).Transwell showed that Sevoflurane decreased the invasiveness of HCC cells(P＜0.05).The scratch test showed that the migration of HepG2 cells decreased after Sevoflurane treatment,with decreased glucose uptake and lactic acid production(P＜0.05).Meanwhile,the extracellular acidified(ECAR) decreased significantly,while the oxygen consumption(OCR) increased(P＜0.05).The expression of BACE1-AS in HCC tissues was significantly higher than that in control(P＜0.05).In addition,prognostic analysis showed that the survival time of patients with high expression of BACE1-AS was significantly shorter，the hazard ratio was 1.75(P＜0.05).The expression of BACE1-AS in three kinds of HCC cells was significantly higher than that in normal hepatocytes(P＜0.05),but the expression of BACE1-AS in hepatoma cells decreased significantly after Sevoflurane treatment(P＜0.05).
Conclusion BACE1-AS is an oncogene in HCC.Sevoflurane can inhibit the proliferation,invasion,migration,glycolysis and apoptosis of HCC cells by inhibiting the expression of BACE1-AS.Sevoflurane is expected to be used as an adjuvant therapy for HCC.

Acoustic neuroma is a kind of benign tumor originating from the vestibular nerve,and most tumors are located near the cerebellopontine angle.For acoustic neuromas with obvious clinical symptoms,tumors gradually increasing during follow-up,and pressure on the surrounding brain tissue,the best treatment is surgery.However,due to the abundant nerves and blood vessels in the cerebellopontine angle,how to remove the tumor completely and avoid damage to the surrounding brain tissue,nerve,and blood vessel is the key to surgical treatment.With the in-depth research on the membranous structures surrounding acoustic neuroma,we believe that understanding the composition of the membranous structures surrounding the acoustic neuroma and its relationship with the tumor,useing the characteristics of the membranous structures，and protecting all the membranous structures through certain techniques during surgery，maybe an important way to remove the tumor tissue as completely as possible and avoid damage to the surrounding tissues of the tumor resulting in postoperative neurological loss.The use of the membranous structures of acoustic neuromas may play a crucial to role in removing acoustic neuroma.

Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death for female in the world.Triple negative breast cancer (TNBC) among its molecular subtypes has become a difficult point in breast cancer treatment due to the lack of clear molecular targets.The first aim for targeted therapy of TNBC is to find reliable biomarkers to identify TNBC.The research of TNBC-related non-coding RNA markers has become a hot spot in this field.Circular RNA (circular RNA,circRNA) is an important type of non-coding RNA，since many researches have indicated that circRNAs play a vital role in many life process like cellular structure and function,gene expression and regulation,signal pathway and particular in the occurrence and development of cancer.In recent years,many literatures have reported circRNA related to the occurrence and development of TNBC and explained its molecular mechanism,some of which can also be used as TNBC biomarkers.This article will review related researches.

Obesity and obesity-associated metabolic dysfunction are risk factors for the occurrence and development of various malignant tumors,including colorectal cancer,breast cancer(especially postmenopausal women),endometrial cancer and so on.Chronic inflammatory response,insulin resistance and adipocytokines are main mechanisms responsible for the tumor-promoting effects of obesity.It is one of the current research hotspots to study the molecular and metabolic mechanisms between obesity and tumor genesis and development,so as to provide new ideas and strategies for the prevention and treatment of tumors.This article will review the basic mechanism,current research focus and new strategies for the prevention and treatment of obesity-related tumors.