Objective:To evaluate the clinical efficacy and safety of hyperthermic intraperitoneal chemotherapy，HIPEC in the treatment of gastric cancer with peritoneal carcinomatosis，GCPC.Methods:The clinical data of 67 patients with GCPC who were treated by surgery and confirmed by pathology were retrospectively analyzed.Among them，46 patients undergo HIPEC treatment，the other 21 patients refuse HIPEC treatment.Treatmentrelated complications and postoperative survival data were compared to analyze the factors involved in the prognosis of GCPC patients.Results:There was no significant difference with respect to treatmentrelated serious adverse event，SAE.Patients who received CRS CCR（0～1）（n=24）and HIPEC（n=15）at the same time had a median OS of 14 months，while those who receive CRS alone（n=9）had a median OS of 6 months（P=0.012）.Multivariate analysis suggested that early HIPEC treatment and regular postoperative chemotherapy bring survival benefit for GCPC patients who underwent CRS CCR（0～1），the elevation of serum CA724 were independent risk factor to postoperative survival time of GCPC.Conclusion:For patients with peritoneal metastasis of gastric cancer who achieve complete tumor cell extinction visible to the naked eye，the treatment strategy of CRS+HIPEC will not increase the occurrence of treatation-related complications，and at the same time can prolong the survival of patients.

Objective:To evaluation the safety and efficacy of self expanding metallic stent in the treatment of complete intestinal obstruction caused by advanced colorectal cancer.Methods:The clinical data of 55 patients with complete intestinal obstruction caused by advanced colorectal cancer from 2016 to 2018 in Wuhan Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology were analyzed retrospectively.Patients were treated with selfexpanding metal stents（stent group，n=37）and surgery（surgery group，n=18）.The postoperative technical success rate，clinical success rate，length of stay，early and late adverse events and overall survival rate were statistically analyzed in both groups.Results:35 patients in the stent group achieved technical success with a technical success rate of 94.6%（35/37），while 18 patients in the surgical group achieved technical success with a technical success rate of 100%（18/18）.Clinical remission was achieved in 89.2% of patients with colon stenting and 100% of surgical patients（P＞0.05）.Compared with the surgical group，the incidence of early adverse events was significantly lower in the stent group（10.8% vs 27.8%，P＞0.05）.The mortality rate was 0 in the stent group during the hospital，compared with 5.56% in the surgical group（P＞0.05）.The average operation time（38.6min）in stent group was significantly shorter than that in operation group（123.9min）（P<0.05）.Compared with the surgery group（16 days），the average length of hospital stay（5 days）was significantly shorter（P<0.05）.The incidence of late postoperative adverse events was comparable between the two groups（13.5% vs 11.1%，P ＞0.05）.At 150 weeks，the survival rate was 29.7% in the stent group and 44.4% in the surgical group（P＞0.05）.Conclusion:Selfexpanding intestinal stent is effective in the treatment of complete intestinal obstruction caused by advanced colorectal cancer，which can significantly shorten the hospitalization time of patients，not increase postoperative complications，and greatly improve the quality of life of patients.The longterm survival of patients is comparable to palliative surgery，which is worth popularizing and applying in clinical practice.

Objective:To explore the effect of intraperitoneal hyperthermic perfusion chemotherapy（HIPEC）on the clinical efficacy and prognosis of patients with peritoneal metastasis of advanced colorectal cancer（CRC）.Methods:A retrospective analysis of 71 patients with CRC peritoneal metastasis from 2016.4 to 2017.4.All the patients were randomly divided into the observation group（34 cases）and control group（37 cases）according to different postoperative treatment.Patients in observation group were treated with intraperitoneal hyperthermic perfusion chemotherapy，and patients in the control group were treated with conventional chemotherapy regimens.After 6 courses of treatment，clinical efficacy，related indicators of recurrence and metastasis，tumor markers，quality of life，and occurrence of adverse reactions after chemotherapy were compared between the two groups.Results:The total effective rate（67.6%）and disease control rate（87.3%）in the observation group were significantly higher than total effective rate（40.5%）and disease control rate（62.2%）in the control group（P<0.05）.After the treatment，the levels of serum carbohydrate antigen 199（CA199）（24.21±1.98），CA125（37.97±2.93），and carcinoembryonic antigen（CEA）（16.26±2.02）in the observation group were significantly lower than the levels of serum carbohydrate antigen 199（CA199）（30.9±3.05），CA125（44.53±3.34），and carcinoembryonic antigen（CEA）（19.68±1.94）in the control group（P< 0.05）.The KPS score was significantly improved，and the 3year survival rate were significantly better in the observation group than in the control group（P<0.05）.There was no significant difference in the incidence of complications between the two groups（P>0.05）.Conclusion:Intraperitoneal hyperthermic chemotherapy can significantly improve the clinical efficacy of chemotherapy in patients with CRC，and effectively control tumor progression and improve the immune function.It will provide novel methods and approaches for the effective treatment of advanced colorectal cancer.

Objective:To investigate the safety and feasibility of laparoscopic surgery with reduced orifice in the treatment of sigmoid colon and upper rectal cancer.Methods:90 patients with sigmoid colon or upper rectal cancer were recruitedfrom January 2018 to may 2019.The patients were randomly assigned to the conventional laparoscopic surgery group and the reduced orifice laparoscopic surgery group，with 45 cases in each group.The preoperative general conditions，intraoperative bloodloss，operation time，exhaust time，outofbed activitytime，hospitalizationtime，hospitalizationexpenses，bowel resection length，incidence of complications，number of resected lymph node and postoperative pain score were compared.Results:The total incision length and postoperative pain score of the two groups were（6.9±0.7）cm and（1.9±0.8），respectively，which were lower than those of the convention laparoscopic surgery group（9.3±0.7）cm and（2.3±0.6），the difference was statistically significant（P<0.05）.There was no significant difference in operation time，intraoperative bloodloss，bowel resection length，exhaust time，outofbed activitytime，hospitalizationtime，hospitalizationexpenses，number of resected lymph node，incidence of postoperative complications，recurrence rate，distant metastasis rateand Diseasefree survivalbetween the two groups（P>0.05）.Conclusion:It is safe and feasible to treat sigmoid colon and upper rectal cancer by laparoscopy surgery with reduced orifice.

Objective:To summarize the experience in the treatment of anastomotic stenosis（AS）after TME for rectal cancer.Methods:The Beijing Chaoyang hospital affiliated to the Capital Medical University ，from 2011 to 2018 treated 512 cases of rectal cancer after TME analysis clinical data of 30 patients with AS，20 of whom underwent anastomotic stenosis ring dissection，6 underwent anastomotic stricture dilatation，3 resection of anal rectum anastomotic stenosis ring，transverse colostomy，double cavity l case for initial choice in bare stents to relieve obstruction，intestinal obstruction due to stent in take out again after 1 month，after a single cavity sigmoid colostomy.Results:After anastomotic stenosis surgery，the patients underwent artificial anastomotic orifice dilatation 2～3 times a day through anus，3～5 minutes each time.No symptoms of anastomotic stenosis were observed during followup.Three months after the protective colostomy，the patient could discharge loose stool.Conclusion:AS is the result of multiple factors.Different treatment methods for AS after TME for rectal cancer can achieve good efficacy according to the stenosis site and degree，which is worthy of clinical reference.

Objective:To investigate the safety and clinical effect of enhanced recovery after surgery（ERAS）in right hemicolectomy for elderly patiens with colon cancer.Methods:65 patients diagnosed with right colon cancer were selected between March 2016 to December 2019 in Guang dong nongken central hospital.According to the digestive tract reconstruction method，the patients were divided into 35 cases in the ERAS group and 30 cases in the control group.ERAS group received enhanced recovery after surgery management，while contral group received traditional managnement.operation time，blood loss，postoperative exhaust and defecation time，postoperative hospital stay，postoperative inflammatory factor level，postoperative complications and patient satisfaction of the two groups was compared.Results:All the 65 patients recovered and were discharged smoothly，and the postoperative exhaust time of ERAS group and control group were（46.8±3.2）h vs（58.4±2.1）h and defecating time were（66.5±4.2）h vs（8.3±3.5）h，respectively.Postoperative hospitalization days were（5.2d vs 8.6d，respectively.The ERAS group were shorter than those in the control group（P<0.05）.The levels of inflammatory factors in postoperative day 1 and day 3，PCT were（1.3±0.2）ng/ml and（3.2±0.6）ng/ml，（0.63±0.14）ng/ml and（1.5±0.2）ng/ml），respectively.CRP were（128.5±3.5）ng/ml and（150.7±7.2）ng/ml，（88.2±4.2）ng/ml and（109.4±6.5）ng/ml，respectively.The postoperative pulmonary infection were 2.86% vs 13.33%，，respectively.Which were lower than the control group（P<0.05）.The satisfaction of patients were 98.6 vs 93.2，respectively.Which was higher than that of the control group（P>0.05），and there was no significant difference in operation time and blood loss between the two groups（P>0.05）.There was no significant difference in postoperative abdominal distension，vomiting and intestinal obstruction between the two groups（P>0.05）.Conclusion:In the elderly patients with right hemicolectomy for  colon cancer ，the application of ERAS can promote the early recovery of gastrointestinal function，shorten the length of hospital stay，reduce the level of inflammatory response，reduce the incidence of post〖LM〗operative pulmonary infection，improve patient satisfaction，and improve medical experience，which is safe and effective.

Objective:To evaluate the sidetoside isoperistaltic anastomosis and functional endtoend anastomosis in digestive tract reconstruction of Crohn's disease.Methods:Clinical and followup data of CD patients who underwent intestinal resection from March 2017 to October 2019 were retrospectively analyzed.Result:Seventytwo CD patients underwent bowel anastomosis 78 times，in which sidetoside isoperistaltic anastomosis（SSIA）63 times（small intestinesmall intestine 44 times，small intestinecolon 10 times，and the coloncolon 9 times），and functional endtoend anastomosis（FEEA）15 times（small intestinethe small intestine 4 times，small intestinecolon 7 times，and coloncolon 4 times）.Anastomotic proximal enterostomy occured in 7 cases.SSIA completion time was（32±14）min，and FEEA completion time（19±6）min.The postoperative hospitalization time of patients receiving SSIA was 7～14 days（mean 9.1 days）.Patients receiving FEEA were hospitalized for 8～15 days（mean 8.7 days）.One patient receiving FEEA and proximal stoma developed anastomotic leakage.There was no anastomotic stenosis in those two anastomotic methods.Conclusion:Both SSIA and FEEA are suitable for gastrointestinal reconstruction after CD intestinal resection.However，SSIA may be preferred for mesenteric hypertrophy or anastomosis of the transverse and left hemicolon.

Objective:To evaluate the effects of  biomarkers，including  neutrophiltolymphocyte ratio（NLR） and fibrinogen content（FIB） to local recurrence  and/ or distant metastasis  and  5year  recurrence  free  survival （RFS） in  patients  with  gastrointestinal stromal tumor（GIST） after  radical  surgery.Methods:170 patients with GIST who was from January of 2010 to December of 2015 in the First Affiliated Hospital of Xi 'an Jiaotong University after radical surgery without neoadjuvant therapy（imatinib）were retrospectively analyzed.The biomarkers included NLR and FIB.SPSS 18 was used for ROC analysis，chi square test，and MannWhitney U test，correlation analysis was performed with the Pearson correlation test.The longterm survival was analyzed by KaplanMeier survival analysis.Multivariate factors for survival were analyzed by Cox proportional hazards regression model.Results:170 patients were included in this study.During followup，24 patients showed recurrence or metastasis，15 patients suffered from GIST related deaths，1 patient was due to the death of car accidents.Establishment of Roc Curve for diagnosis of GIST，the area under the ROC curve of NLR and FIB was 0.608，0.758，respectively.When NLR=1.864，FIB=3.24g /L was taken as the dividing point respectively，NLR and FIB had the highest sensitivity and specificity in the diagnosis of GIST.There was a correlation between NLR，FIB and age，sex，tumor location，size and risk grade of GIST patients，and there was also a correlation between NLR and FIB.The RFS of 5 years after the operation was 75% in the present study.5 years RFS rate of NLR<1.864 group and greater in the NLR group were 90% and 62%，respectively（P=0.018），FIB＜3.24 g/L and greater in the FIB group were 95% and 50%，respectively（P＜0.01）； FIB and NLR were jointed and divided into 4 groupsGroup 1：FIB＜3.24g/L and NLR＜1.864，Group 2：FIB≥3.24g/L and NLR〖LM〗 ＜1.864，Group 3：FIB≥3.24g/L and NLR≥1.864，Group 4：FIB＜3.24g/L and NLR≥1.864，and 5 year RFS rate of 4 group were 100%，78%，38% and 92%，respectively（P＜0.01）.Multivariate analysis showed that FIB（P＜0.01，HR=0.108，95%CI：0.0290.333）and NIH risk classification（P=0.001，HR=0.128，95%CI：0.0370.443）was an independent risk factor affecting the prognosis of GIST.Conclusion:The combination of NLR and FIB can effectively predict the postoperative prognosis of GIST patients，but this conclusion needs further study and confirmation.

Objective〖WTBZ〗〓To investigate the clinical effect of application of enhanced recovery after surgery（ESAS）in total laparoscopic D2 radical resection for distal gastric cancer.〖WTHZ〗Methods〖WTBZ〗〓75 patients with distal gastric cancer confirmed by endoscopy were randomly divided into 2 groups：group A was treated with accelerated rehabilitation surgery group（42 cases），and group B was treated with conventional laparoscopic group（33 cases）.The operation time，intraoperative blood loss，first anal exhaust time，first time of postoperative ambulation，and postoperative hospital stay were recorded in 2 groups.The visual analogue scale（VAS）was used to assess pain at 12h，24h，48h，and 72h after surgery.The nausea verbal descriptive scale（NVDS）was used to evaluate nausea and vomiting within 24 hours after surgery.The abdominal distension was used to evaluate bloating.The daily living ability scale（ADL）was used to evaluate daily living ability 3 days after surgery.The postoperative hemorrhage，postoperative gastroparesis，postoperative intestinal obstruction，postoperative anastomosis or stump fistula were collected from both groups.Satisfaction with postoperative pain management，postoperative nausea and vomiting control satisfaction，postoperative bloating control satisfaction and overall hospitalization satisfaction questionnaire were used.Results:There was no significant difference in the operation time  and intraoperative blood loss between the two groups（P>0.05）.Compared with group B，the time to get out of bed and the first postoperative anal exhaust time and the hospital stays in group A had decreased（P＜0.05），the VAS in group A [T12，〖LM〗T24，T48，T72 had significantly decreased（P＜0.05），the  postoperative nausea and vomiting and abdominal distensionhad significantly decreased（P＜0.05），and ADL had increased in group A（P＜0.05）.There were no serious complications such as gastric fistula，intestinal obstruction，anastomotic stoma or stump fistula in both groups.Compared with group B，the postoperative pain ，postoperative nausea and vomiting and bloating control satisfaction  and overall hospitalization satisfaction  had inncreased in group A（P＜0.05）.Conclusion:Perioperative application of ERAS in patients undergoing total laparoscopic radical gastrectomy is safe and effective.

Objective:To explore changes of serum IgA，SAA，CCL5 and inflammatory cytokines in patients with anal fistula before and after operation and their relationship with anal function and efficacy.Methods:114 anal fistula patients admitted to our hospital from October 2017 to January 2019 were selected as research objects，all of whom received surgical treatment.The serum levels of IgA，SAA，CCL5 and IL4，IL6 and IL10 were detected by enzymelinked immunosorption method.The changes in serum levels of IgA，SAA，CCL5 and IL4，IL6 and IL10 and the anal function scores of patients before and after surgery were compared to explore the relationship between serum IgA，SAA，CCL5 and IL4，IL6 and IL10 and the anal function and surgical effect of patients.Results:After treatment，the levels of IgA，SAA，CCL5，IL4，IL6，IL10 and Wexner scores of the patients were significantly decreased（P<0.05），and the differences were statistically significant（P<0.05）.Postoperative effects of IgA，SAA and CCL5 patients in the low level group were better than those in the high level group，with statistically significant differences（P<0.05）.Patients in the lowlevel IL4，IL6 and IL10 group were better than those in the highlevel group，with statistically significant differences（P<0.05）.IgA，SAA，CCL5，IL4，IL6 and IL10 were positively correlated with the course of disease and Wexner score（P<0.05），and negatively correlated with the treatment effect（P<0.05），but had no significant correlation with gender or age（P>0.05）.Conclusion:The serum levels of IgA，SAA，CCL5 and inflammatory factors in patients with anal fistula after surgery are all lower than those before surgery.The serum levels of IgA，SAA，CCL5 and inflammatory factors are closely related to the operation effect and postoperative anal function of patients.

Objective:Analysis of the clinical diagnostic value of color Doppler ultrasound and molybdenum target imaging in the detection of BIP and DCIS.Methods:The color ultrasound，molybdenum target and pathological data of 141 patients were reviewed，including BIP（69 cases，71 lesions）and DCIS（67 cases，67 lesions）.The detection rates of BIP and DCIS indicated by color ultrasound and molybdenum target were compared.Results:The detection rate of tumor with calcification and simple tumor type signs indicated by color ultrasound was 5.63% and 91.55% respectively for BIP，89.55% and 5.97% for DCIS，while the detection rate of two positive characteristics indicated by molybdenum target was 60.56% and 38.28% for BIP，68.66% and 31.34% for DCIS，In the overall analysis of positive signs，compared with color ultrasound.There were statistical differences in the diagnosis of BIP and DCIS（P<0.05）.Conclusion:In the diagnosis of BIP and DCIS，more attention should be paid to the examination value of molybdenum target，but the two examinations complement each other and are equally important.

Objective:To compare the prognosis of acute kidney injury and the absence of acute kidney injury with Stanford type A aortic dissection，and to analyze the high risk factors leading to acute kidney injury after surgery.Methods:From May 2014 to May 2016，75 patients with acute kidney injury after Stanford type A dissection were treated as a case group.Age and body weight were matched in 75 normal renal function groups as control group.The risk factors for acute kidney injury were analyzed.The prognosis of the two groups was compared.Results:The incidence of early complications of patients with acute kidney injury after Stanford type A aortic dissection increased about 1.9 times，and the rate of lung infection increased about 1.7 times compared with those who without.After 3 years of followup，the followup rate was 97.0% ，and the average followup was 28 months.The survival rate freedom from longterm complications decreased from 1 month，12 months，24 months，and 36 months after acute kidney injury compared with those who did not（94.2%，91.2%，80.5% and 26.4% vs.100%，98.6%，91.5% and 77.8%； Logrank P<0.01）.The perioperative highdose positiveinotropicdrugs（OR=3.455；95%CI：1.163～10.265）and static renal vascular damage（OR= 8.726；95%CI：2.149～35.426） were risk factors for acute kidney injury after Stanford type A dissection.Conclusion:Stanford type A aortic dissection surgery is dangerous，perioperative highdose positiveinotropicdrugs and static renal vascular damagewere risk factors for acute kidney injury after suregy.Those patients have a poor prognosis.Prevention is better than cure.

Objective：To observe the treatment effect of zoledronic acid dosing every 12 VS 4 weeks in patients with prostate cancer metastatic to bone.Methods:52 patients with prostate cancer and bone metastases were assigned to receive 4.0mg of intravenous zoledronic acid every 4 （group A）or every 12 weeks （group B）for 1 year.The clinical value about twoway therapy were evaluated on SRE rate、first SRE and skeletal morbidity rate、uNTX/Cr ratio、bone pain relief rate、number of bone metastases and adverse events.Results：Treatment delay was observed in 64.0% of group A and 33.3% of group B，and the difference between the two groups was statistically significant（P<0.05）.SREs occurred in 5 patients（20.0%）in group A and 6 patients（22.2%）in group B.The SREs rate and the time to first SRE（occured about 30 weeks）between two groups were not significantly different（P＞0.05）.The mean SMR was 0.46 vs 0.50 events per year in in group A and group B（P＞0.05）.The uNTX/Cr ratio had no statistical difference between the 2 treatment groups in each time period（P＞0.05），except at the 48 weeks.Bone pain relief rate of two groups was not statistically significant in each time point.Adverse events：In group A，the proportion of patients in digestive tract reaction and hypopotassemia was higher than another group.But all AEs in two groups had no statistical difference.Conclusion：The every 12 weeks regimen of zoledronic acid was noninferior to the every 4 weeks regimen for treatment of patients with bone metastasis from prostate cancer in relief bone pain and control the progression of bone lesions.This longer interval may be an acceptable treatment option.

Objective：To summarize the experience of nonsurgical treatment in the treatment of pancreatic trauma in children.Methods：The data of 13 cases of pancreatic trauma from February 2013 to October 2018 were retrospectively analyzed.Results：All 13 cases underwent enhanced CT scan of the pancreas and accorded with the diagnosis.According to the grading table made by the American Society of Traumatic Surgery，there were 4 cases in Grade I，4 cases in Grade II，3 cases in Grade III，2 cases in Grade IV and 0 cases in Grade V.All cases were treated conservatively by antiinfection，fasting，gastrointestinal decompression，total parenteral nutrition，enzyme inhibition，partial puncture and drainage，or ERCP stent drainage（1 case）.All cases were cured without open surgery and no recurrence.Conclusion：The ability of repairing pancreas in healthy children is strong.Most children with pancreatic trauma are cured by conservative treatment.Even pancreatic trauma with rupture of the main pancreatic duct of the head of the pancreas can be cured by nonopen surgical treatment such as external drainage or combined with intraductal stents.

Colorectal cancer is one of the commonly human malignant tumors.The effective treatment for this disease is still early finding and timely surgery now.Nutritional therapy of perioperative patients with colorectal cancer has great significance for ensuring the safety，enhancing recovery，and reducing the complications of the surgery.This article introduces firstly the epidemiological trend of colorectal cancer and then focuses on the interpretation on tools of nutritional screening and assessment，individualized strategy of nutritional therapy，the selection of enteral nutrients，and evaluations of specific nutrients for the perioperative patients with colorectal cancer.

Robotic surgery overcomes the limitations of conventional laparoscopy associated with anatomy and offers certain advantages，including magnification，virtual 3D imaging，flexible wrist with seven degree of freedom，dexterity，superior microsurgical capabilities，lack of tremors，motion scaling，a short learning curve and friendly manmachine interface.The tight confines of the deep narrow pelvis make the robot a good match for medlow rectal surgery.Robotic rectal surgery has been shown to reduce conversions as compared to laparoscopic surgery in the majority of studies，but it is associated with longer operative times than the conventional laparoscopic approach.Preliminary research shows that postoperative shortterm outcome and longterm prognosis are equivalent between the two approaches.The possible superiority of robotic surgery in terms of the preservation of autonomic function allows for the preservation of urinary and sexual functions after nerve preserving TME.Even so，it should be emphasized that the cooperation and training for members of the surgical team will be required and the costs and benefits still needs to be further improved and optimized.The effects of robotic rectal cancer resection on the shortterm outcome，quality of life and prognosis of patients need to be investigated and validated by a rigorous desiged multicenter RCT study. 

Due to the sharp increase of COVID19 infected cases，infectious specialized hospitals with negative pressure operating rooms have been unable to satisfy the needs of COVID19 surgical patients，and it is inevitable for general hospitals to make surgical treatment of suspected or confirmed emergency COVID19 patients.Therefore，it is urgent to implement the practice in the operating room at the stage of prevention and control of COVID19.During this period，the isolated operation area should be selected and transformed to meet the requirements of the three areas and two channels.The emergency training and assessment of the whole surgical team members（surgeons，anesthesiologists，surgical nurses，auxiliary staff）can not only provide mutual protection，but also avoid the waste of protective supplies，prevent the spread of infection and more shortage of protection materials.Emergency deployment，storage and management of protective supplies are to ensure clinical requirements.Rapid development of human resources plans，care of staff（especially nurses who support fever clinic，ICU and compartment hospital）quickly respond to the human support in and out of OR.Revision and sharing of surgical procedures and emergency plans，so that the whole team members know how to prevent from infection and compliant.Strengthen the communication with the medical aid teams for Hubei province to better deal with the emergency operation service for them.In the process of the practice，we realize the skills training with the infection prevention and control measures for medical staff is the biggest difficulty and challenges，reasonable human resource deployment and humanistic care and knowledge reserves are the key points to eliminate panic among employees，multidisciplinary collaborative discussion is to guarantee the area reconstruction and process revision，orderly grouping responsibility system is the driving force to carry out the practice efficiently.

The outbreak of novel coronavirus pneumonia has greatly affected the lives and health of people in China.Panic，anxiety and pessimism are among the general population.At the same time，because of the need of epidemic prevention and control，some areas have implemented measures such as limiting treatment，shunting treatment，outpatient stopping treatment，which also caused difficulties for some patients with prostate diseases.Prostate diseases can be seen in adult men of all ages，including common prostate cancer，hyperplasia，prostatitis and other diseases.During the period of epidemic prevention and isolation，professional guidance is urgently needed.In the epidemic prevention and screening，community doctors played a huge role in the first line of epidemic prevention and control，but the community doctors may not have enough awareness of prostate specific diseases，and lack of energy.Based on this，we have connected prostate patients，community screening doctors and urologists of the top three hospital in series to form a linkage mechanism，which effectively solved the diagnosis and treatment needs of some patients in line with the needs of epidemic prevention and control，and formed a set of threelevel linkage mechanism.This article will give a brief introduction of the relevant process，hoping that the linkage system can play a role of inspiration，referencen in similar major public health events.