Abstract: [Abstract] Objective To investigate the efficacy of stepwise decompression with intracranial pressure monitoring combined with different timing of skull defect repair in patients with sTBI and the effect on their serum indicators and prognosis. Methods Seventy-three patients with STBI who were admitted to our hospital were selected for the study.They were divided into 2 groups according to the differences in treatment modalities.Among them,40 patients in the study group were treated with intracranial pressure monitoring step decompression combined with ultra-early skull defect repair,while 33 patients in the control group were treated with intracranial pressure monitoring step decompression combined with conventional time skull defect repair,comparing the clinical efficacy and other differences between the two groups. Results After treatment,the rate of good recovery was significantly higher in the study group than in the control patients(P<0.05);All inflammation-related test indexes in the study group improved significantly after treatment compared with the control group(P<0.05);After treatment,the incidence of complications was significantly lower in the study group than in the control group(P<0.05).The mean MCA flow velocity in the study group improved significantly after treatment compared with the control group(P<0.05).After treatment,the prognosis of the study group was significantly better than that of the control patients(P<0.05). Conclusion The efficacy of intracranial pressure monitoring step decompression combined with ultra-early skull defect repair in the treatment of patients with heavy craniocerebral injury is remarkable,and it can reduce the inflammatory state of patients and improve their cerebral perfusion,and reduce the incidence of complications.

Key words: intracranial pressure monitoring step decompression, ultra-early skull defect repair, heavy craniocerebral injury, efficacy, serum, prognosis