Abstract: Objective To evaluate the pharmacodynamics of target-controlled infusion of rocuronium in patients undergoing surgery for obstructive jaundice.Methods Sixty patients undergoing elective open biliopancreatic surgery under general anesthesia in our hospital from August 2020 to August 2021 were selected and randomly divided into two groups: 30 patients received targeted infusion of rocuronium(observation group),30 patients received intermittent intravenous injection of rocuronium(control group).The total intubation dose,onset time,muscle relaxation recovery time,maintenance dosage and total dosage of rocuronium during induction were compared between the two groups,and the muscle relaxation monitoring indexes during anesthesia maintenance were observed between the two groups.Results he induction time of target-controlled infusion rocuronium was significantly longer than that of intravenous infusion group,and the induction dose of rocuronium was significantly higher than that of intravenous injection group(P<0.01).The time of T1 recovery to 25%,75%,90% and recovery index in the target-controlled infusion group were significantly shorter than that of intravenous injection group after drug withdrawal(P<0.01).The amount of rocuronium per unit time maintenance and total amount of rocuronium during operation were significantly decreased in the target-controlled infusion group(P<0.01).Surgeons’ satisfaction with muscle relaxation was higher under target-controlled infusion(P<0.01).Conclusion Target-controlled infusion of rocuronium is not suitable for induction in patients with obstructive jaundice,but the maintenance of target-controlled infusion is more suitable for such patient,which may reduce the amount of intraoperative muscle relaxants,reduce postoperative residual muscle relaxants,and promote rapid recovery of patients.

Key words: obstructive jaundice, rocuronium, target-controlled infusion