Abstract: Objective To explore the experience of parathyroid function protection during endoscopic surgery in papillary thyroid cancer. Methods The clinical data (the number of recognized and misdissected parathyroid glands;the number of preserved in situ and autotransplantated parathyroid glands;Ca²⁺ and PTH) of 198 patients with PTC were retrospectively analysed:open surgery was performed in 104 cases;endoscopic surgery was performed in 94 cases;all the cases used carbon nanoparticles during operation. Results No statistically significant difference was observed between the identification rates of type A1,A2,or B1,and the preservation in situ rates of type A1 in the two groups (P>0.05).Significant differences were found between the identification rates of type A2,B1 and total parathyroid glands,and the preservation in situ rates of type A2,B1,and total parathyroid glands in the 2 groups (P<0.05).There was no significant differences of the levels of Ca²⁺ and PTH before operation,and the levels of Ca²⁺ on postoperative day was found between the two group(P＞0.05).The PTH level in endoscopic surgery was significantly lower than that in open surgery,and decreased significantly compared with that before surgery(P＜0.05).Conclusion The negative development technique of carbon nanoparticles can effectively protect the parathyroid function during the operation of PTC,but surgeons should pay more attention to injection methods and accurate dissection.

Key words: nano-carbon, papillary thyroid cancer, endoscopic surgery, parathyroid gland, function protection