Abstract: Objective To investigate that efficacy of video-assisted thoracoscopic surgery(VATS) and total video-assisted thoracoscopic lobectomy in the treatment of early-stage non-small cell lung     canc(NSCLC) and the effects on serum inflame matory factor.Methods A total of 86 patients with early NSCLC who were treated in the thoracic surgery of Yibin Second People’s Hospital from January 2018 to January 2020 were selected and divided into the research group(n=45) of anatomic segmentectomy under VATS and the control group(n=41) of lobectomy under VATS according to the surgical method.The surgical effects and changes in pulmonary function indexes of the two groups were compared.The serum levels of Creacive protein(CRP),interleukin-1β(IL-1β),interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) before and after treatment were detected.Results The operation time,intraoperative bleeding volume,postoperative drainage volume and postoperative drainage time in the research group were significantly higher than those in the control group(P<0.05).The hospital stay in the research group was significantly lower than that in the control group(P<0.05).There was no statistical difference in the number of lymph node cleanings between the two groups(P>0.05).Preoperative FEV1%,FVC% and PEF pulmonary function indexes showed no significant difference between the two groups(P>0.05).The percentages of FEV1% and FVC% after surgery in the two groups were significantly lower than those before surgery,and the PEF was significantly higher than that before surgery with statistical significance(P<0.05).The levels of FEV1%,FVC% and PEF in the postoperative study group were significantly higher than those in the control group(P<0.05).Serum CRP,IL-1β,IL-6,and TNF-α levels of the two groups on day 1 and day 3 after surgery were significantly higher than those before surgery(P<0.05).The levels of serum CRP,IL-1β,IL-6,and TNF-α on day 1 after surgery were significantly higher than those on day 3 after surgery(P<0.05).The levels of serum CRP,IL-1β,IL-6,and TNF-α in the study group were significantly lower than those in the control group 1d and 3d after surgery(P<0.05).Conclusion VATS anatomical segmentectomy in the treatment of early NSCLC can effectively improve lung function of patients and significantly reduce the body inflammatory response.

Key words: video-assisted thoracoscopic surgery, non-small cell lung cancer, anatomical segmental resection, lobectomy of lung, inflammatory factor