Abstract: Abstract Colorectal cancer (CRC) is one of the most common malignant tumors. Although the diagnosis of CRC has made great progress, most patients are in advanced stage when diagnosed, accompanied by tumor infiltration and distant metastasis, resulting in poor prognosis. Long non-coding RNA (lncRNA) is one of the main causes of CRC, but the potential mechanism of lncRNA in CRC remains to be further explored. The role of lncRNA in CRC is closely related to the following biological processes, such as apoptosis and escape, angiogenesis, cell cycle, epithelial mesenchymal transition(EMT), DNA damage repair and epigenetics. In this paper, we systematically described the diagnostic value of lncRNA in CRC, then described the role of lncRNA in CRC cell apoptosis and escape, angiogenesis, cell cycle, EMT, DNA damage repair and epigenetics, and finally described the application value and prospect of lncRNA in CRC.

Key words: colorectal cancer, long non-coding RNA, gene