Abstract: [Abstract] Objective To investigate the value of modified Glasgow prognostic score(mGPS)  combined with Fibrinogen to pre-albumin ratio(FPR) in the prognostic evaluation of thoracoscopic lobectomy for lung cancer.Methods The clinical and follow-up data of 63 patients with lung cancer who underwent thoracoscopic lobectomy in Huanggang Central Hospital from October 2016 to December 2019 were retrospectively analyzed.FPR of patients before surgery was detected and calculated,and the mGPS was recorded.The receiver operating characteristic curve(ROC) was used to determine the optimal cut-off value of FPR,and χ² test was used to analyze the relationship between mGPS,FPR and the clinicopathological characteristics of lung cancer,and single factor and multivariate Cox proportional hazard regression models were used to analyze the influence factors related to the prognosis of patients with lung cancer underwent thoracoscopic lobectomy.Results According to the mGPS,0 points were included in the normal group(38 cases),and 1~2 points were included in the abnormal group(25 cases).The best cutoff value of FPR by ROC curve was 0.096,and the patients were divided into the high FPR group(FPR>0.096,n=19) and low FPR group(FPR≤0.096,n=44).The proportion of TNM III stage in lung cancer patients with abnormal mGPS and high FPR was higher(P<0.05).The 3 year disease-free survival rate of the normal mGPS group and the low FPR group was higher than that of the abnormal mGPS group and the high FPR group(78.95% vs 48.00%,75.00% vs 47.37%)(P<0.05).The 3 year disease-free survival rate of 18 patients with abnormal mGPS combined with FPR(abnormal mGPS and high FPR) was 38.89%,which was significantly lower than that of the two non-uniform abnormal lung cancer patients(77.78%,P<0.05).TNM stage Ⅲ,abnormal mGPS,high FPR,and abnormal mGPS combined with FPR(abnormal mGPS and high FPR) were all independent risk factors of the prognosis of lung cancer patients after thoracoscopic lobectomy(P<0.05).Conclusion he survival rate of lung cancer patients undergoing thoracoscopic lobectomy with abnormal preoperative mGPS or high FPR is significantly reduced,and the survival rate of patients with both abnormalities is lower.The combination of mGPS and FPR is expected to be an effective indicator for evaluating the prognosis of lung cancer patients.

Key words: modified Glasgow prognostic score, fibrinogen to pre-albumin ratio, thoracoscopic lobectomy, lung cancer