Abstract: Objective To investigate the clinical effect of surgical treatment for moyamoya disease complicated with intracranial aneurysm. Methods A retrospective analysis was performed on 264 patients with moyamoya disease treated by surgery in Department of Neurosurgery,Renmin Hospital of Wuhan University from January 2015 to June 2021,including 233 patients in the non aneurysmal group(patients with moyamoya disease treated with intracranial and extracranial artery bypass) and 31 patients in the aneurysmal group(patients with moyamoya disease complicated with intracranial aneurysm underwent bypass and intracranial aneurysm interventional embolization or craniotomy clipping).DSA or CTA follow-up was performed and mRS scores were recorded. Results Among 237 patients with complete follow-up data,209 patients had good prognosis(mRS<3),including 191 patients(191/212,90.1%) in the non aneurysmal group and 18 patients(18/25,72.0%) in the aneurysmal group( P <0.05).157 patients with early Suzuki stage had good prognosis.Among them,there were 144 cases(144/233, 61.8 %) in the non aneurysmal group and 13 cases(13/31,41.9%) in the aneurysmal group( P < 0.05 ). Conclusion Compared to patients with MMD alone,the Suzuki stage of patients with MMD complicated with intracranial aneurysm is higher,which will increase the incidence of postoperative complications and make the prognosis  poor.

Key words:  moyamoya disease, intracranial aneurysm, vascular bypass, craniotomy clipping, endovascular embolization