Abstract: Objective To analyze the effects of different doses of dexmedetomidine on postoperative agitation and oxidative stress in children undergoing abdominal surgery.
Methods Totally 175 children undergoing abdominal surgery under general anesthesia in our hospital from January 2019 to September 2020 were randomly divided into 5 groups,with 35 cases in each group,by random number table method.Dexmedetomidine(0.4 μg/kg,0.6 μg/kg,0.8 μg/kg and 1.0 μg/kg)was used in the first four groups during anesthesia induction.The levels of adrenaline,glucagon,blood glucose and cortisol;and the postoperative analgesia and sedation scores were evaluated.
Results Restlessness score in group A to D was significantly lower than that in group E(P＜0.05);postoperative sedation and analgesia in group B,C and D were significantly better than those in group A and E(P＜0.05).
Conclusion The optimal dose of dexmedetomidine in pediatric abdominal surgery is 0.8 μg/kg.

Key words: Dexmedetomidine, oxidative stress response, restlessness, dosage