Abstract: Objective To investigate starting early solifenacin treatment in patients with high preoperative OABSS after transurethral resection of the prostate(TURP) would be reasonable.
Methods A total of 127patients(OABSS score>5) undergoing TURP were prospectively evaluated and divided into two groups according to their OABSS.Those with a score of ≥11 points were Group 1(G1),and those with ≤10 points Group 2(G2).In addition,patients in each group were randomly further divided into two subgroups:those who were started on 5 mg solifenacin succinate in the earlypostoperative period(G1A/G2 A) and those who were not(G1B/G2B).
Results Preoperative OABSS score:G1A group 11.63±1.149,G1B group 12.43±1.165,G2A group 6.41±1.142,G2B group 6.30±1.311;OABSS score in three months after operation:G1A group 5.26±1.196,G1B group 7.63±2.092,G2A Group 5.57±2.940,G2B group 4.55±2.862;G1 group and G2 group three months after the OABSS score comparison P=0.007(P<0.05);G1A and G1B comparison P<0.001,G2A and G2B comparison P=0.138(P>0.05).
Conclusion Solifenacin succinate treatment in the early postoperative period may be beneficial for patients with high preoperative OABSS.

Key words: benign prostatic hyperplasia, overactive bladder, transurethral resection of the prostate, Solifenacin