Abstract: Objective:To investigate the clinical characteristics and prevention strategies of acute disseminated intravascular coagulation(DIC) hemorrhage which happened in organ transplant recipients.Methods:The clinical data,DIC treatment strategy,test indicators of 6 patients who underwent organ transplantation between August 2019 and August 2020 with acute DIC hemorrhage,were retrospectively analyzed.Results:The coagulation function and platelets of 6 patients were abnormal on the day of surgery,and were diagnosed as acute DIC according to the DIC rating scale of the International Society of Thrombosis and Stasis(ISTH).DIC was corrected after early.Rapid and massive infusion of clotting substances and platelets during operation,and the coagulation function basically returned to normal within 1 week after the operation as well as graft function,except for DGF in 1 renal transplant recipient.Conclusion:The cause of DIC in organ transplant recipients are complex and dangerous,which may be related to high PRA and abnormal coagulation function before operation;Early,rapid and massive intraoperative infusion of clotting substances and platelets is the key to correct acute hemorrhagic DIC;After the occurrence of actue DIC hemorrhage in organ transplant recipients,the early recovery of graft function is not affected,provided that blood perfusion during the operation is necssary.

Key words: organ transplanntation, acute disseminated intravascular coagulation hemorrhage, clotting substances