Abstract: Objective：To investigate the safety and effectiveness of subtotal parathyroidectomy with autotransplantation (SPTX+AT) for the treatment of secondary hyperparathyroidism.Methods：Fiftyfour patients with SHPT from January 2019 to October 2019 were collected and treated with SPTX+AT.Information on patients' preoperative and postoperative clinical symptoms,PTH levels,and blood electrolyte levels were collected,and the above indicators were followed up every 3 months after surgery for a period of at least 1 year to judge the safety and effectiveness of the surgery.Results：Fiftyfour patients who met the inclusion criteria successfully completed the surgery,and their postoperative symptoms improved and their PTH,blood calcium and blood phosphorus levels decreased(P<0.05).The surgery was effective in 51(94.4%) cases with PTH below 150 pg/ml or a decrease of more than 70%.8(14.8%) patients developed hypocalcemia,which was stabilized to normal range in the third month of followup.There were 4(7.4%) cases of recurrence at 1 year of followup.Conclusion：The efficacy of SPTX+AT in treating SHPT is accurate and feasible; the incidence of hypocalcemia after surgery is low,and reoperation after recurrence is relatively simple and safe,which has certain advantages over the existing procedures.

Key words: secondary hyperparathyroidism, parathyroidectomy；chronic kidney disease