Abstract: Objective:To explore the corresponding measures to prevent anastomotic stenosis after esophagectomy for esophageal and cardiac cancers.Methods:Retrospective analysis was made on the clinical data of 315 patients with esophageal and cardia cancers with oesophagectomy performed in the department of Thoracic Surgery of the Nanyang central hospital from January 2013 to January 2018.In the experimental group(146 cases),oral gentamicin saline was taken before operation,anastomosis was performed after intraoperative gastric wall pouch suture,and anastomotic tension was reduced.Solid food and oral acidinhibiting drugs were taken as early as possible after operation.The control group(169 cases) only adopted stapler anastomosis directly.Postoperative followup has been conducted for two years,and the incidence of anastomotic stenosis in the two groups was compared.Results:The incidence of anastomotic stenosis in the control group was 11.0%,while the incidence of anastomotic stenosis in the experimental group was 3.8%.The difference was statistically significant（P＜0.05）.Conclusion:Preoperative oral administration of gentamicin saline,intraoperative pursestring suture of the stomach wall before anastomosis,and reduction of anastomotic tension can actively prevent anastomotic stenosis.

Key words: esophageal cancer, anastomotic stenosis, purse string suture of gastric wall, prevention