Abstract: Pancreatic cancer is a kind of digestive system malignant tumor with late clinical discovery, high degree of malignancy and poor prognosis. In order to improve the prognosis of patients, it is of great clinical significance to explore an economical, accurate and minimally invasive method for early diagnosis and improve the resection rate of surgery.Liquid biopsies are used to detect a variety of tumor-related biomarkers, such as circulating tumor cells, circulating tumor DNA, and exosomes, in extractable body fluid samples. Recent studies have shown that liquid biopsy plays an important role in early diagnosis of pancreatic cancer. In this paper, the advantages, limitations and clinical application prospects of liquid biopsy-related markers in early diagnosis of pancreatic cancer were reviewed.

Key words: pancreatic cancer, early diagnosis, liquid biopsy, circulating cancer cell, circulating tumor DNA, exosome