Abstract: Objective  Evaluation of adhesion prevention efficacy of Sirolimus(SRL)-loaded hydrogel composite mesh under the condition of intraperitoneal onlay mesh(IPOM) in piglet model.
Methods  Laparoscopic technique was used to repair abdominal wall by IPOM method,then the SRL-loaded hydrogel was injected on the surface of the mesh to form the anti-adhesion composite mesh(SRL/gel/PP).The adhesion area,adhesion tenacity degree was evaluated.The virgin PP mesh and PROCEED mesh were used as control.Then the inflammation reaction and collagen disposition of surrounded monofilament was also evaluated.
Results  The hydrogel could fix on the surface of mesh and peritoneum.The SRL/gel/PP presented an excellent prevention abdominal adhesion property with a little few inflammation reaction and collagen disposition.SRL/gel/PP mesh could integrate with abdominal wall as well as no displacement and shrinking.
Conclusion  The SRL-loaded hydrogel composite mesh adapted to repair the abdominal defect with the IPOM method for prevention abdominal adhesion.

Key words: hydrogel, Sirolimus, abdominal wall repair, laparoscopic technique