Abstract: Objective  To investigate the consistency of pathological results and immunohistochemical results between specimens obtained by Ultrasound-guided core needle biopsy(USCNB)and postoperative in the breast cancer and to analyze the influence of tumor size on it.To understand the accuracy of USCNB in the diagnosis of axillary lymph node(ALN)metastasis.
Methods  Retrospectively analyzed the clinicopathological data of 431 patients with breast cancer.Compared the pathological results of USCNB with postoperative pathology to understand the detection rate of breast cancer and the accuracy of ALN metastasis diagnosis by USCNB and to understand the consistency of immunohistochemistry(ER,PR,HER-2 and Ki-67) between USCNB and postoperative pathology.Analyzed of the influence of breast tumor size on the detection rate and immunohistochemistry consistency of breast cancer.
Results  417 cases were diagnosed of breast cancer by USCNB,the detection rate of breast cancer was 96.75%.The analysis indicated that there was no significantly difference of the detection rates of USCNB for breast cancer among groups with different tumor size(P>0.05).For the pathological diagnosis of abnormal ALN by USCNB,the accuracy was 90.34%(131/145),the sensitivity was 88.50%(100/113),the specificity was 96.88%(31/32),the false negative rate was 11.50%(13/113),and the false positive rate was 3.13%(1/32).The diagnostic coincidence rates of ER,PR,HER-2 and Ki-67 were 92.11%,90.49%,89.33%and 70.30%.The Kappa values were 0.780,0.752,0.743 and 0.290,AUC values of ER,PR and HER-2 were 0.719,0.700 and 0.479.The consistency between USCNB and ER,HER-2 decreased with the increase of tumor(P<0.05),but there was no significant difference in the coincidence rates of PR and Ki-67 among different tumor size groups(P>0.05).
Conclusion  USCNB is a reliable diagnostic method for breast cancer and ALN staging.The consistency of ER and PR between specimens obtained from USCNB and postoperative is good.The consistency of ER and HER-2 is related to the tumor size.

Key words: breast cancer, ultrasound-guided core needle biopsy, immunohistochemical, consistency； axillary lymph node