Abstract: Objective To investigate the clinicopathological characteristics,diagnosis and differential diagnosis of lymphocyte aggregation lesions.
Methods The immunohistochemical Ventana Bench Mark method was used to detect 9 cases of lymphocyte aggregation lesions and follow up closely.
Results 9 cases of lesion sites:4 cases of tonsils,2 cases of pharynx,2 cases of breast,1 case of duodenal mucosa.The course of the disease was 2 weeks to 2 months,and the follow-up was 4 to 78 months.No recurrence was found.Except for the duodenum,which was polyp-like,the others were flat and raised lesions.The histology showed that lymphocytes were gathered under the epithelium and filled In the lumen of each lymphatic vessel,the blood vessels around the lymphatic vessel proliferate obviously,and the surrounding interstitium has obvious fibrotic structure.Immunophenotype:T lymphocyte markers CD3,CD5,CD43 diffuse and strong positive,CD4,CD8 partial cells are positive,B lymphocyte markers show scattered cells are CD20 positive,judged as negative.
Conclusion The accumulation of a large number of lymphocytes in the lymphatic vessels shows a benign lymphocytic proliferation disease,with chronic inflammation and interstitial fibrosis,which may lead to local lymphatic duct compression and lymphocyte retention;the histology is similar to intravascular lymph The tumor showed a single and diffuse T lymphocyte immunohistochemical results,but the cells did not have atypical characteristics,and the patient's clinical symptoms showed isolated inflammatory changes without obvious malignant biological behavior.This performance is conducive to differential diagnosis.

Key words: lymphatic vessels, benign, lymphocytes, T lymphocytes, B cells, aggregation