Abstract: Objective To investigate the predictive value of preoperative neutrophil lymphocyte ratio (NLR) and plasma fibrinogen (FIB) levels in the prognosis of operable gastrointestinal stromal tumors.
Methods A total of 85 patients with surgical gastrointestinal stromal tumors who were treated in Huai’an First People’s Hospital from January 2015 to December 2018 were selected.NLR and FIB were detected before surgery，and the patients were followed up.The follow-up deadline wasFebruary 2020.The effects of NLR and FIB on progression-free survival (PFS) and overall survival (OS)，the factors affecting PFS and OS，and the predictive value of NLR combined with FIB on the prognosis of surgical gastrointestinal stromal tumors were observed.
Results The follow-up time of this group of patients was 14～60 months.The average follow-up time was (46.9±6.8) months.A total of 5 patients were lost to follow-up and 10 died.The ROC curve analysis results showed that the areas under the NLR and FIB prediction survival were 0.77 and 0.72.The sensitivity of NLR combined with FIB prediction survival was 68.2% and the specificity was 86.3%.Kaplan-Meier and Log-rank test results showed that the PFS and OS of the high NLR group were shorter than that of the NLR group，and the difference was statistically significant (P<0.05).The PFS and OS of the high FIB group were shorter and the difference was statistically shorter(P<0.05).Multivariate Cox analysis showed that NLR,FIB，and tumor risk were independent factors affecting PFS and OS in patients with operable gastrointestinal stromal tumors (P<0.05).
Conclusion The prognosis of patients with operable gastrointestinal stromal tumors with elevated NLR and FIB is poor.Preoperative NLR and FIB levels can be used to predict the prognosis of patients，and NLR combined with FIB is of high value in predicting the survival rate of gastrointestinal stromal tumors.

Key words: neutrophil lymphocyte ratio, fibrinogen, gastrointestinal stromal tumor, prognosis