Abstract: Objective To explore the clinical characteristics，diagnosis，treatment and prognosis of sarcomatoid carcinoma of the gallbladder.
Methods Symptoms，syndrome，preoperative imaging，tumor markers，surgery and prognosis of five patients confirmed with sarcomatoid carcinoma of the gallbladder in our hospital from April 2012 to April 2020 were retrospectively analyzed.
Results The five patients had no obvious specificity.Preoperative tumor marker examination showed that CA-199 increased significantly in 2 patients.CA-125 increased significantly in 2 patients.CEA increased slightly in 1 patient，and ferritin increased significantly in 5 patients，there was no significant difference between the imaging findings and gallbladder adenocarcinoma.Four of them underwent R0 resection and one case underwent R1 resection.Up until the last follow-up visit，one patient survived at 8 months after surgery and the other four cases did not survive for a long term（survival time 63～340 day）.
Conclusion Sarcomatoid carcinoma of the gallbladder has no specific clinical manifestations，so it isgenerally diagnosed via pathological examination and immunohistochemical examination.The cancer is highly malignant and progresses very rapidly.Radical excision is dominant in clinical treatment.Because its incidence rate is very low，more cases should be followed up for long term to search for better treatment.

Key words: gallbladdersarcomatoid carcinoma, treatment , prognosis