Abstract: Objective：To investigate the clinical effect of adjustable negative pressure drainage in the treatment of lower extremity venous ulcer.Methods：31 patients with lower extremity venous ulcer were treated with adjustable negative pressure drainage after surgical debridement.Results：The wounds of 13 patients healed gradually after 1～2 negative pressure cycles，without autologous free skin grafting in the later stage；18 patients were treated with autologous free skin grafting after 1～3 negative pressure cycles and covered with granulation tissue，and the skin grafting area survived completely after one week of continuous negative pressure drainage after skin grafting.The wound healed well.Conclusion：The application of adjustable negative pressure drainage technology in the treatment of venous ulcer of lower extremities can significantly improve the healing speed of wounds and reduce dressing change times.Less pain that the patients will suffer.The operation is simple and the curative effect is reliable.

Key words: adjustable, negative pressure drainage, lower extremity venous ulcer