Abstract: Objective Purpose Making a multi-perspective analysis of the drug sensitivity result of 46 patients with ureteral calculus and concomitant urinary infection so as to offer valuable medication instruction.Methods Respectively analyzing clinical information of patients diagnosed with ureteral calculus in our hospital from January，2016 to December，2017，and selecting out 46 cases from all 402 cases with ureteral calculus.To compare the populations of the microbial community，drug sensitivity，anti-bacterial effects and effectiveness of cephalosporins in order to confirm the more rational choice of drugs.Results It had been showed that E.coli was the major bacterial of both genders and 25（54%）samples were positive; while men had a relatively lower percentage of E.coli to all bacteria compared to women，but no statistical significance（RR=0.68，95% CI：0.344～1.185，P＞0.05）.Enterubacterium had a high resistance rate for single betalactam antibiotics while significantly improved sensitivity and decreased resistance were acquired when combined with Betalactamase inhibitors（sulbactam/tazobactam）（OR=0.058，95% CI：0.022～0.151，P<0.05）.According to drug sensitivity results（sensitive、intermediary、resistant）of 7 different cephalosporins，it had notable distinction.So Cefoxitin and Cefoperazone combined with sulbactam as the major antibiotics for empirical medication were screen out as the ideal antibacterial drugs.Conclusion We recommend Cefoxitin or Cefoperazone combined with sulbactam as the first choice，Ceftazidime and Cefepime as the second choice，meanwhile decreasing the application of Ciprofloxacin and Levofloxacin.

Key words: E.coli, drug sensitivity, ureteral caculus, cephalosporins