Abstract: Objective To compare the clinical effects of continuous negative pressure drainage system and conventional compression dressing with free skin grafting.Methods Ninety-eight patients with acute and chronic wounds from March to September 2018 who requiring skin grafting were randomly divided into two groups according to the different methods of intraoperative skin banding.The control group（n=49 cases）was used free skin grafting with conventional compression dressing.The observation group（n=49 cases）was treated with free skin grafting and continuous negative pressure drainage system.The surgical outcomes，such as the excellent rate of surgery，satisfaction，operation time，and wound healing time，and the incidence of postoperative complications such as hematoma，infection，and skin failure were compared.Results The excellent and good rate of surgery（95.92%）and satisfaction（97.96%）were significantly better in the observation group than in the control group（71.43%，73.46%）（P<0.05）.The operation time of the observation group was significantly shorter than that of the control group（P<0.05）.The wound healing time was also significantly faster than the control group（P<0.05）；the incidence of postoperative complications（6.12%）in the observation group was significantly lower than that of the control group（22.45%）（P<0.05）.Conclusion The application of continuous negative pressure drainage system in conventional skin grafting can significantly improve the surgical outcome and postoperative patient satisfaction，promote wound healing and reduce the incidence of postoperative complications.

Key words: skin graft, pressure dressing, continuous negative pressure drainage system