Abstract: Objective Exploration and analysis of the clinical application of computer-aided design combined with 3D printing technology in cervical spine fracture and dislocation of cervical spine fracture.Methods The clinical data of 70 patients with cervical spine fractures and dislocations who were treated in our hospital were collected and divided into two groups according to different treatment methods：The observation group（35 cases）was treated with computer-aided design combined with 3D printing technology，and the control group（35 cases）was treated with conventional CT-assisted surgery.The parameters of the operation time，intraoperative blood loss，and exhaust time of the two groups were recorded and analyzed，and the position of the postoperative screw was set.Analysis and evaluation of JOA score and VAS before and after treatment.Statistics and analysis of the occurrence of postoperative adverse reactions in patients.Results The operation time（95.2±10.4）min，the amount of bleeding（148.9±8.2）ml and the exhaust time（2.5±1.1）d in the observation group were better than the control group[（108.3±7.6）min，（208.8±9.1）ml，（3.1±0.6）d]（P<0.05）.The success rate of postoperative fixation（85.71%）in the observation group was higher than that in the control group（68.57%）（P<0.05）.The JOA scores of the two groups were higher than those before treatment.The JOA score of the observation group（15.64±1.48）was higher than that of the control group（14.73±1.51）（P<0.05）.The VAS scores of the two groups were lower than before treatment.The VAS score of the patients（3.16±0.46）was lower than that of the control group （3.42±0.33）（P<0.05）.The incidence of adverse reactions in the observation group（8.57%）was lower than that in the control group（17.14%），the difference was not statistically significant（P>0.05）.Conclusion Cervical spine fractures and cervical dislocation patients with computer-aided design combined with 3D printing technology for treatment，with short operation time，low damage，good therapeutic effect and high safety，it is worthy of clinical application.

Key words: computer-aided design, 3D printing technology, JOA score, VAS score