Abstract: Objective：To investigate the gene distribution of esophageal squamous carcinoma in han population in northwest China.Methods：52 patients with esophageal squamous cancer who had undergone esophagectomy were studied.The clinical data and the results of genetic test of these patients were collected.The relationship between gene expression and the clinical pathological characteristics were studied.Luminer liquidphase chip and FISH method were used.Results：Eighteen esophageal cancer related genes，including ERCC1，BRCA1，TYMS，RRM1，TUBB3，STMN1，TOP2A，EGFR，PDGFR，VEGFR1，VEGFR2，VEGFR3，KIT，HER2，IGF1R，PTEN，PDL1and 21gene，were tested and only 10 genes were positive expressed（positive rate 55.2%），including ERCC1，BRCA1，TYMS，RRM1，TUBB3，STMN1，TOP2A，VEGFR1，HER2，PTEN.The expression levels of ERCC1，TUBB3，HER2 and PTEN had no significance correlation with clinicopathological characteristics in esophageal squamous cancer patients.The lymph node metastasis rate and tumor stage of low expression level of TYMS patients was statistically higher than high expression patients（P<0.05）.The expression level of RRM1 was statistically associated with smoking（P<0.05）.Conclusion：The gene expression was specific in esophageal squamous cancer patients of Chinese Han population from singlecenter of northwest China and this study may supply the potential targets for the genetic treatment of esophageal squamous cancer.

Key words: esophageal cancer, genetic test, target therapy