Abstract: Objective To investigate the clinical effect of oxycodone on tracheal catheter tolerance during awake period after general anesthesia in patients with tongue cancer.Methods 90 patients with radical surgery for tongue cancer were randomly divided into three groups（Q group，S group and Y group），30 patients in each group，all under routine anesthesia induction and anesthesia maintenance.Oxycodone 0.1mg/kg（Q group），sulfentanil 0.1μg/kg（S group），and normal saline 5ml（Y group）were intravenously administered 30min before the end of the operation.The sedation-agitation score after recovery and the postoperative events（cough frequency，hemodynamic changes and adverse reaction）of the three groups of patients were quantified.Results The hemodynamic changes in Q group and S group were more stable than those in group Y（P<0.05）;The sedation-agitation scores in Q group（4.1±0.2）and S group（4.2±0.3）were significantly lower than those in Y group（5.7±0.3）（P<0.05）.And the postoperative cough frequency in the Q group and S group were both less than that in the Y group（P<0.05）.The number of cough（2.1±0.6）in Q group within 6 hours after operation was reduced compared with that in S group（3.6±1.3）（P<0.05）.There was no significant difference in the patient's adverse reactions（Y group：8 cases，Q group：10 cases，S group：9 cases）（P>0.05）.Conclusion Oxycodone displayed improved effects compared to sulfentanil in reducing the number of postoperative coughs which makes the patient better tolerate the tracheal tube.

Key words: Oxycodone, tongue cancer, tracheal catheter tolerance