Abstract: Objective：To study the regulation and mechanism of Fbxw7 on gastric cancer cell migration and invasion.Methods：SGC7901 cells were transfected with pcDNA3.1Fbxw7，then Fbxw7 mRNA level was detected by RTPCR，cell migration and invasionweremeasured by transwell assay，the expression level of mTOR wasdetected by western blot.Results：Compared with control cells，the cells transfected with pcDNA3.1Fbxw7 showed increased Fbxw7 mRNA level，decreased migration and invasion ability，downregulated level of mTOR.Conclusion：Overexpression of Fbxw7 inhibits migration and invasion ability，also promotes mTOR degradationin gastric cancer SGC7901 cells，indicating that Fbxw7 may regulate gastric cancer metastasis through mTOR signaling pathway.

Key words: Fbxw7, gastric cancer, cell migration and invasion, mTOR