Abstract:

Objective To investigate the changes of Caprini score，plasma D-D and FIB levels in patients with post-fracture DVT and its diagnostic significance.Methods Sixty patients with postfracture DVT（DVT group）and 120 patients without DVT after fracture were selected（control group）.The Caprini score，plasma D-D and FIB levels were compared between the two groups.The relationship between Caprini score and plasma D-D and FIB in the DVT group was analyzed.Results The Caprini score，D-D and FIB levels in the DVT group[7.26±1.88，（3.31±1.52）mg/L，（4.48±0.72）g/L] were significantly higher than those in the control group[3.39±0.80，（0.46±0.11）mg/L，（3.60±0.68）g/L]，and the difference was statistically significant（P<0.05）.There was a significant positive correlation between Caprini score and D-D and FIB levels in patients with DVT（P<0.05）.There was a positive correlation between Caprini score and level of D-D and FIB（r=0.748、r=0.662，P<0.05）.The sensitivity of Caprini score combined with D-D and FIB levels in the diagnosis of DVT in fracture patients was 97.83%，specificity was 92.00%，missed diagnosis rate was 2.17%，misdiagnosis rate was 8.00，and area under ROC curve was 0.947（P<0.05）.Conclusion Caprini score，D-D and FIB levels in patients with lower limb fracture have certain clinical value for the diagnosis of DVT.

Key words: Caprini score, D-two dimer, fibrinogen, fracture, deep vein thrombosis of lower extremity