Abstract: Objective:To analyze the clinical advantages，prognosis and safety of transurethral singlehole laparoscopic cholecystectomy（TULESS）compared with the traditional endoscopic cholecystectomy.Methods:100 patients with benign gallbladder disease were selected in our hospital.According to different surgical methods they were divided into two group，50 cases in each group.Group A treated with TULESS，group B used of traditional laparoscopic treatment.The surgical status，postoperative 3dVAS score，postoperative abdominal aesthetics and hospitalization were evaluated.Results:The average size of incision，blood loss，postoperative exhaust time，hospital stay time，postoperative complications rate，postoperative 3dVAS score and hospitalization costof group A were lower than group B，the difference was statistically significant（P<0.05）.The postoperative aesthetic satisfaction score of abdominal wall in group A was higher than that of group，the difference was statistically significant（P<0.05）.Conclusion:Compared with the traditional endoscopic cholecystectomy，TULESS operation has characterized of less damage to the patient，reduce postoperative complications，rapid recovery，with higher degree of cosmetic abdominal wall.

Key words: transumbilical laparoendoscopic singlesite surgery, endoscopic cholecystectomy, gallstone, gallbladder polyps, safety