Abstract: Objective:To study the effect of skull base reconstruction after neuroendoscopic transsphenoidal pituitary adenoma resection on the quality of life of patients.Methods:90 patients with pituitary adenoma received the treatment of neuroendoscopic transsphenoidal pituitary adenoma resection combined with skull base reconstruction in our hospital.The resection of pituitary tumors，occurrence of complications and improvement of symptoms 1 month after operation were observed and recorded.The hormone levels were measured before and 1 month after surgery.After 3 months of followup，the Chinese version of SNOT20 scale was used to score the patient's nasal quality of life.Results:The total removal rate of pituitary adenoma was 81.11%.The structure of nasal cavity of 7 patients changed after operation，and the symptoms of menstrual disorder，visual impairment，headache and sexual dysfunction were significantly relieved（P<0.05）.After operation，the abnormal rates of PRL，ACTH，TSH and HGH decreased significantly（P<0.05）.Compared with preoperative，the score of the patient's nasal quality of life tested by the Chinese version of SNOT20 scale were significantly improved.Conclusion:In the treatment of Neuroendoscopic transsphenoidal pituitary adenoma combined with skull base reconstruction，the total resection rate of pituitary tumor is high，the postoperative complications occur less，and the symptom relief rate is high，which can effectively improve the nasal quality of life of patients.

Key words: neuroendoscopic transsphenoidal pituitary adenoma resection, skull base reconstruction, quality of life