Abstract: Objective To investigate the effect of early cranial defect repair on nerve function of patients.Methods 60 patients with cranial defect admitted to our hospital were selected.They were randomly divided into control group（n=30）and observation group（n=30）.The control group was treated with traditional cranial defect repair（3～ 6 months after operation）and the observation group with early cranial defect repair（1～3 months after operation）.The ADL score，Fugl-Meyer score and quality of life score were compared between the two groups.Results The excellent and good rate of the patients with early cranial defect repair was 93.33%，which was significantly higher than that of the control group（66.67%，P<0.05）.Tthe ADL score and Fugl-Meyer score of the observation group with early cranial defect repair was significantly higher than that of the control group（P<0.05）.The scores of neurological impairment of the observation group were significantly lower than those in the control group（P<0.05），and the scores of the SF-36 scale in the observation group were significantly higher than those in the control group（P<0.05）.Conclusion Early cranial defect repair can help patients with skull defect to improve the clinical efficacy，improve the ability of daily life，quality of life，motor function and reduce the somatic pain and the degree of postoperative neurological deficit.The clinical effect is remarkable.

Key words: early stage, cranial defect repair, nerve function, improvement effect