Abstract: [Abstract] Objective：To investigate the clinical efficacy of splenectomy combined with splenic graft transplantation in treatment of Ⅲ～Ⅳ degree traumatic splenic rupture patients and its effect on immune function and risk of thrombosis.Methods：80 cases of Ⅲ～Ⅳ degree traumatic splenic rupture patients were regarded as research subjects，which were divided into study group with 40 cases and control group with 40 cases.Patients in control group were given routine splenectomy and patients in study group were given implantation of autologous spleen segments after splenectomy.The two groups were compared in terms of clinical efficacy.Results：The study group[（91.2±18.5）min] takes more time than control group[（76.6±15.0）min，P<0.05].The operative blood loss，postoperative hospital stay and postoperative complications were no significant difference（P＞0.05）.There was no significance in postoperative complications rate between study group（20.0%）and control group（12.5%，P＞0.05）.The immune function indexes were all better in study group than in the control group after the treatment（P＜0.05）.The platelets level at 1，2 weeks and 1 month after surgery in the study group was significantly lower than in the control group（P＜0.05）.The Tuftsin level in the study group was significantly higher than in the control group（P＜0.05）.Conclusion：The implantation of autologous spleen segments after splenectomy in the treatment of Ⅲ～Ⅳ degree traumatic splenic rupture patients is significant，which can accelerate the recovery of the patient's immune function and reduce the risk of thrombosis，but the indications should be strictly controlled.

Key words: splenectomy, implantation of autologous spleen segments, splenic rupture, immune function, thrombosis