Abstract:   Objective     To analyse the clinical efficacy of ProUK and catheterdirected thrombolysis for acute lower extremity arterial thrombosis.Methods sixtyfive patients with acute lower extremity arterial thrombosis were selected in our department.35 cases were enrolled with catheterdirected thrombolysis（ProUK group），and the remaining 30 were treated with urokinase（control group）.Observe the change before and after thrombolysis.Among the ProUK group，there were 22 cases as experimental group，and compared with 30 cases of urokinase control group，the arterial patency and adverse reactions after thrombolysis were evaluated.Results  Among the 35 patients in the ProUK group，thirtythree cases were effective，two were ineffective and the effective rate was 94.3%.Among the 30 patients in the control group，twentyone cases were effective，nine were ineffective and the effective rate was 70%.Postoperative ABI was increased in most patients（P<0.05）.Compared with the control group，the recanalization rate was higher in the experimental group and the difference was statistically significant（P<0.05）.There was no significant difference in the incidence of adverse reactions between the two groups（P＞0.05）.All patients were followed up had different degrees of improvement in symptoms.Conclusion  The efficacy of ProUK and catheterdirected thrombolysis for acute lower extremity arterial thrombosis is superior to that of urokinase.

Key words: acute lower extremity arterial thrombosis, catheterdirected thrombolysis, ProUK