Abstract: [Abstract] Objective To investigate the therapeutic effect of minimally invasive transforaminal interbody fusion（MISTLIF）in the treatment of single segment lumbar degenerative disease.Methods  The data of 82 patients with single segment lumbar degeneration disease were divided into two groups：group A（n=40）were treated by minimally invasive transforaminal interbody fusion （MISTLIF），group B（n=42）were treated by open intervertebral foramen interbody fusion （OpenTLIF）.Compared the efficacy of the two surgical methods.Results Operation time of group A was （141.3±10.8）minutes，intraoperative fluoroscopy was （12.0±1.5），while the data of group B were （118.5±10.3）minutes and （4.0±1.0），respectively（both P＜0.05）.In group A，intraoperative blood loss was （127.5±1.3）ml，postoperative drainage was （95.8±3.1）ml，postoperative bed time was （28.0±1.5）hours，postoperative hospital stay was （120.0±2.4）hours and the number of cases without serious complications.The data of group B were （320.5±1.2）ml，（72.0±3.2），（144.0±2.1）hours，，respectively.Severe complication was happened in 2 cases.There were statistical significance between the two groups（P＜0.05）.Waist pain VAS scores of 7 days and 3 months after surgery of group A were （2.0±0.5）and （3.1±0.4），respectively.While the data of group B were （3.5±0.5）and （2.0±0.5），respectively.There were statistical significance between the two groups（P＜0.05）.After 18 months of evaluation results in group A without translocation and sinking of fusion and internal fixation failure，Ⅰ level and Ⅱ level fusion were 29 cases（72.5%） and 11 cases（27.5%），respectively.group B fusion shift happeded in 2 cases，no sink fusion and internal fixation failure patients，Ⅰ level and Ⅱ level fusion were 26 cases （61.9%）and 16 cases（38.1%），respectively.Conclusion  The MISTLIF method in the treatment of lumbar vertebra degeneration disease，which patients have lesser trauma，shorter hospitalization，patients can quick recovery after operation.

Key words:  , spinal canal neurilemmoma, posterior laminectomy, clinical efficacy