Abstract: Objective  To study the expression level of SIRT7 in the gastric cancer，analyze the correlation between SIRT7 and clinicopathological characteristics of gastric cancer，and explore possible mechanisms of the involvement of SIRT7 in the occurrence and development of gastric cancer.Methods 195 cases of gastric carcinoma and paracarcinoma tissues were collected.Western blot was used to detect the protein expression of SIRT7 in gastric carcinoma and adjacent tissues.Immunohistochemistry was operated to detect the expression of SIRT7 and the correlation between SIRT7 and clinicopathological characteristics of gastric cancer.Results The positive rate of SIRT7 expression in gastric cancer（65.64%）was significantly higher than in the adjacent tissues（19.49%）（P<0.05）.The expression of SIRT7 was not related to age，gender and the size of tumor（P＞0.05），but related to lymph node metastasis，depth of invasion and TNM staging（P<0.05）.Conclusion  The expression of SIRT7 in gastric cancer is higher than in normal tissues，and is correlated with lymph node metastasis，depth of invasion and TNM staging，suggesting their roles in the gastric cancer.