JOURNAL OF CLINICAL SURGERY ›› 2024, Vol. 32 ›› Issue (7): 693-696.doi: 10.3969/j.issn.1005-6483.2024.07.007

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Programmed cell death 10 mediates the migration of glioma cells by regulating the PP2A/p38 signaling pathway

WAN Xueyan,XIE Jiazhao,ZHAO Kai,KONG Fanli,MEI Qi   

  1. Department of Neurosurgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China
  • Received:2024-03-27 Online:2024-07-20 Published:2024-07-20

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Abstract: Objective To explore the molecular mechanism of programmed cell death 10 (PDCD10) mediating glioma migration.Methods A PDCD10-silenced glioma cell line (U251) was constructed by siRNA,and the cells were treated with Okadaic Acid (OA),a protein phosphatase 2A (PP2A) phosphatase inhibitor,to investigate the effect of down-regulation of PDCD10 on the behavior of U251 cells; Western Blot (WB) was applied to detect the expression of PDCD10,PP2A,PP2Ac-307,p38 and pP38 in the control group and PDCD10 down-regulation group of U251 cells,to study the mechanism of PDCD10 regulation of PP2A/p38 signaling.Results Down-regulation of PDCD10 in U251 cells promoted the cells migration (P<0.05),which could be inhibited by PP2A phosphatase inhibitor OA (P<0.01).Further studies showed that down-regulation of PDCD10 promoted glioma cell migration via modulating the phosphorylation of PP2A,which in turn altered the activity of p38 (P<0.01).Conclusion PDCD10 may mediate glioma cell migration by regulating PP2A/p38 signaling.

Key words: programmed cell death 10, glioma, migration, PP2A/P38

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