Abstract: Objective To explore the risk factors of bile leakage in patients with common bile duct stones (CBDS) after choledochoscope and duodenoscope combined with Laparoscopic choledochal exploration of stone calculi for primary suture.Methods A total of 176 patients with CBDS undergoing triple endoscopy combined with choledocholithotomy for primary suture were enrolled as the research objects between January 2019 to October 2022.The clinical data of patients and occurrence of postoperative bile leakage were statistically analyzed.The risk factors of bile leakage were analyzed by multivariate regression analysis.Results In the 176 patients with CBDS undergoing triple endoscopy combined with choledocholithotomy for primary suture,there were 29 cases (16.48%) with bile leakage.Multivariate Logistic analysis showed that serum albumin ≤ 35g/L,stone incarceration,diameter of common bile duct ≤1cm and no nasobiliary drainage were risk factors of bile leakage. Conclusion Serum albumin ≤35g/L,stone incarceration,diameter of common bile duct ≤1cm and no nasobiliary drainage are risk factors of bile leakage after triple endoscopy combined with choledocholithotomy for primary suture.Clinically,early prevention and supportive treatment can be conducted for patients with high-risk factors to reduce the incidence of postoperative bile leakage.

Key words: common bile duct stone, bile leakage, risk factor