Abstract: Objective To evaluate the clinical efficacy of unilateral and bilateral percutaneous vertebroplasty(PVP) combined with high viscosity bone cement in the treatment of thoracolumbar osteoporotic vertebral compression fractures(OVCFs). Methods From January 2017 to December 2020, 83 patients with thoracolumbar OVCF underwent PVP in our hospital.According to the surgical method,they were divided into a unilateral group(43 cases) or a bilateral group(40 cases).The unilateral group underwent unilateral percutaneous vertebroplasty with high viscosity bone cement,and the bilateral group Bilateral percutaneous vertebroplasty with high viscosity bone cement was performed.Bone cement dispersion in the fractured vertebra was observed.The operation time,fluoroscopy frequency,injection volume of bone cement,compression degree of anterior vertebral body,Cobb angle of kyphosis,bone cement leakage rate,visual analogue scale(VAS) score and ODI(The Oswestry Disability Index) score were recorded.Results Among the 83 patients included,the operation time and frequency of fluoroscopy in the unilateral group were significantly lower than those in the bilateral group(P<0.05).The amount of bone cement injected in the bilateral group was significantly higher than that in the unilateral group(P<0.05).Compared with the baseline,the VAS scores and ODI scores of the two groups at 1 month and 6 months after operation were significantly decreased(P<0.05).There was no significant difference in the leakage rate of ground bone cement between the two groups(P>0.05).Conclusion Unilateral or bilateral high-viscosity bone cement PVP in the treatment of thoracolumbar OVCF can relieve pain and improve spinal function,and has a good clinical effect.Unilateral approach has the advantages of short operation time and less fluoroscopy.

Key words: osteoporotic vertebral compression fracture, high viscosity bone cement, percutaneous vertebroplasty