Abstract: Objective To investigate the predictive significance of serum intact parathyroid hormone (iPTH) and calcium for permanent hypoparathyroidism (PHPP) after total thyroidectomy,and to observe the correlation with postoperative renal functional.Methods 16 PHPP patients 6 months after total thyroidectomy in Nanjing drum tower hospital from July 2019 to July 2021 were selected as the PHPP group.48 patients who did not develop PHPP within 6 months after surgery were randomly selected as the control group.The serum iPTH and calcium were compared between 2 groups before operation,1 d and 3 d after operation.The relationship between serum iPTH and calcium on the 1st and 3rd day after surgery and renal function in PHPP group after surgery were analyzed.The related influencing factors of PHPP after total thyroidectomy were analyzed.Results Compared with the control group,the serum iPTH and calcium on the 1st and 3rd day after operation were lower,the serum BUN and SCr at 6 months after operation were higher in the PHPP group(P＜0.05).The serum iPTH and calcium 1 d and 3 d after operation were negatively correlated with the serum blood urea nitrogen(BUN) and serum creatinine,(SCr) in the PHPP grou(P＜0.05).Logistic multivariate regression analysis showed that Hashimoto’s Thyroiditis,tumor size,parathyroid incision,serum iPTH and calcium on the 1st and 3rd day after surgery were influencing factors for PHPP after total thyroidectomy (P＜0.05).The receiver operating characteristic curve(ROC) showed that the area under the curve (AUC) of the serum iPTH combined with calcium on the 1st after operation was the largest.Conclusion Serum iPTH and calcium are low expressed on the 1st after total thyroidectomy.The serum iPTH combined with calcium on the 1st after surgery has a high value in predicting PHPP,and are related to the renal function in patients.

Key words: total thyroidectomy, intact parathyroid hormone, serum calcium, permanent hypoparathyroidism, renal function