Abstract: Objective To investigate the effects of naborphine combined with dexmedetomidine on the serum β-Endorphins(β-EP),prostaglandin-E2(PGE2),tumor necrosis factor- α(TNF-α) and interleukin-6(IL-6)in patients with undergoing laparoscopic radical gastrectomy.Methods 126 patients with laparoscopic radical gastrectomy in our hospital were randomly divided into two groups,63 cases in each group.In group C,dexmedetomidine hydrochloride was injected intravenously 10 minutes before anesthesia induction(1μg/kg).the N group was injected  Naborphine(0.2 mg/kg).The anesthetic effect between two groups were compared.Results Compared with that before anesthesia induction,the levels of MAP and HR were increased in C group and N group at the time of extubation(P<0.05).the levels of serumβ-EP,PGE2,TNF-αand IL-6  were significantly higher in N group than that in the C group(all P<0.05).the RS score of the N group were lower than that in the C group(P<0.05).Conclusion Naborphine combined with dexmedetomidine can maintain hemodynamic stability and reduce surgical stress response in laparoscopic radical gastrectomy for gastrointestinal tumors.

Key words: naborphine, dexmedetomidine, gastrointestinal neoplasms, β-Endorphins, prostaglandin-E2