Abstract: [Abstract] Objective To evaluate the effect of VPI on the survival of patients with postoperative stage ⅢA/N2M0 non-small cell lung cancer.Methods Using the Surveillance,Epidemiology,and Final Results(SEER) database,we screened patients with stage ⅢA/N2M0 non-small cell lung cancer who underwent surgery between 2010 and 2015.Cox proportional hazards regression is used to determine factors related to survival.Kaplan-Meier was used to analyze cancer-specific survival(CSS) and overall survival(OS) between the non-VPI group and the VPI group.Results Prognostic factors related to the VPI included race(P<0.001) and adenocarcinoma(P<0.001).VPI was an important independent prognostic factor of OS(HR,1.432;95% CI,1.082-1.573,P=0.006). Conclusion Our results show that VPI is a poor prognostic factor in patients with postoperative stage ⅢA/N2 non-small cell lung cancer.Studies have shown that chemotherapy significantly improves the overall survival rate of patients with stage ⅢA/N2M 0 non-small cell lung cancer after surgery,and reduces the related mortality of lung cancer,especially for non-VPI patients.

Key words: non-small-cell-lung-cancer, visceral pleural invasion, survival prognosis