Abstract: Objective To identify the prognostic role of hsa-mir-337 in breast cancer.Methods The TGGA database was used to gain miRNA-seq expression as well as clinical data.R software was used for data analysis.Univariate Cox analysis as well as Multivariate Cox analysis were used to identify the prognostic significance of hsa-mir-337 in BREAST CANCER patients.GSEA was performed to analyze the functional annotation of the predicted genes. Results Hsa-mir-337 was significantly associated with overall survival(OS)of BREAST CANCER.The low expression group had worse OS compared to the high expression group.Through Multivarite analysis with Cox proportional hazards model indicated that hsa-mir-337(HR=0.981062,P<0.001) was independent progonostic factor for patients with breast cancer. Conclusion Hsa-mir-337 was identified as an independent factor in the prognosis of breast cancer.

Key words: breast cancer, hsa-mir-337, the cancer genome atlas, prognosis