Abstract: Objective To investigate the treatment strategies of pancreatic leak in bladder-drained simultaneous pancreas and kidney transplantation(SPK) recipients. Methods Retrospective,three cases of SPK recipients with pancreatic leakage,all medical history,clinical data,and treatment strategies were recorded and analyzed. Results All the three SPK recipients had bladder-drained pancreatic grafts.Pancreatic leakage occurred in two patients during the perioperative period of SPK and in one recipient at one-year post-transplantation.Bladder decompression,full drainage and transplanted duodenum fistula repair were the main strategies,in addition to symptomatic supportive treatments including antibiotic treatment,inhibition of pancreatic exocrine secretion,maintenance of homeostasis and nutritional support.Eventually,all the 3 patients were successfully cured without any graft loss or patient death. Conclusion Severe pancreatic leakage in SPK patients can lead to serious consequences,which can be effectively treated by drainage and transplanted duodenum fistula repair.

Key words: simultaneous pancreas and kidney transplantaction, bladder drainage, pancreatic leak