Abstract: Objective To detect the expression of prostate specific membrane antigen (PSMA) in prostate cancer tissues,and to analyze the relationship between PSMA and clinicopathological characteristics of patients and its prognostic value. Methods Data of 280 cases of prostate cancer patients and 40 cases of prostate hyperplasia patients treated in our hospital from January 2015 to September 2018 were retrospectively analyzed.Paraffin section specimens of the patients were collected and immumohistochemical staining was performed.Using IHC to detect the expression of PSMA,and to analyze the correlation between PSMA expression and clinicopathological characteristics.Finally,Cox proportional risk model was used to analyze the independent prognostic factors affecting the biochemical relapse-free survival (BRFS) of patients. Results Of the 280 prostate cancer patients,216 cases (77.1%) were positive for PSMA.Of the 40 cases of prostate hyperplasia,17 cases (42.5%) were positive,and the positive rate was lower than that of the prostate cancer group(P<0.05).The positive expression rate of PSMA in patients with lymph node metastasis and Gleason score > 7 was higher than that in patients without lymph node metastasis and Gleason score ≤7,and the difference was statistically significant(P<0.05).Positive expression of PSMA and lymph node metastasis were independent prognostic factors affecting BRFS in prostate cancer patients(P<0.05). Conclusion The high expression of PSMA in prostate cancer tissues is closely related to lymph node metastasis and Gleason score,and can be used as an independent prognostic factor affecting BRFS of prostate cancer patients.

Key words:  prostate cancer, prostate specific membrane antigen, prognosis