Abstract: [Abstract] Objective To investigate the effect of debridement combined with negative pressure wound therapy on wound healing and infection in patients with deep second-degree burn.Methods Ninety patients with burn treated in the hospital from March 2018 to March 2021 were selected as the research subjects.Among them,49 patients treated with debridement combined with routine dressing change were included in the control group,while 41 patients treated with debridement combined with negative pressure wound therapy were included in the observation group.Wound healing status was compared between the two groups.Results The complete healing time of the observation group was significantly shorter than that of the control group [(23.48±4.27) d vs.(26.57±3.84) d] (P＜0.05).The wound healing rates in the observation group at T1,T2 and T3 were higher than those of the control group [(14.64±3.27)% vs.(11.57±3.51)%,(54.38±10.63)% vs.(40.41±9.58)%,(75.26±8.47)% vs.(62.19±9.03)%],and VAS scores were lower than those of the control group [(3.54±1.27) vs.(4.75±1.13),(2.24±0.78) vs.(3.05±0.81),(1.84±0.56) vs.(2.47±0.62)] (P＜0.05).At T1,the incidences of wound redness and secretion in the observation group were lower than those in the control group (41.46% vs.63.27%,43.90% vs.63.27%) (P＜0.05).The wound infection rates and positive rates of secretion bacterial culture in the observation group at T1 and T2 were lower than those in the control group (2.42% vs.20.41%,0.00% vs.14.29%;4.89% vs.26.53%,2.42% vs.18.37%) (P＜0.05).At 6 months after treatment,the incidence of scar and VSS score in the observation group were lower than those in the control group [14.63% vs.36.73%,(5.64±1.53) vs.(8.25±2.17)] (P＜0.05).Conclusion Debridement combined with negative pressure wound therapy can effectively improve wound healing rate in patients with deep second-degree burn,shorten wound healing time,and reduce wound infection rate,wound pain and scar formation.

Key words: deep burn, electrotome debridement, negative pressure wound therapy, wound healing