Abstract: Objective To evaluate the levels of Pre-S1 antigen(PreS1Ag),Hepatitis B surface antigen(HBsAg) and PreS1Ag/ HBsAg levels,and to explore the effect of PreS1Ag/HBsAg levels on the risk of hepatocellular carcinoma in patients with HBV-related cirrhosis. Methods From March 2019 to April 2021,61 HBV-related liver cirrhosis patients in First People's Hospital of Hefei and 61 HBV-related liver cirrhosis patients without liver cancer from March 2019 to April 2021 were retrospectively enrolled.PreS1Ag/HBsAg levels,a logistic regression prediction model was established to analyze the effects of PreS1Ag,HBsAg levels and PreS1Ag/HBsAg levels on the risk of liver cancer in patients with HBV-related cirrhosis,and the ROC curve and decision curve were used to evaluate the predictive efficacy and clinical practicability of the model. Results The levels of PreS1Ag,HBsAg and PreS1Ag/HBsAg in patients with HBV-related cirrhosis were(112.36±20.47) ng/ml,(3.67±0.29) log IU/ml,and 1.14±0.20,respectively;Logistic regression analysis showed that age ,HBsAg,PreS1Agand PreS1Ag/HBsAg were risk factors for the risk of liver cancer in patients with HBV-related cirrhosis.ROC curve analysis showed that a predictive model was established based on multivariate Logistic regression analysis results.The results showed that HBsAg,PreS1Ag,and PreS1Ag/HBsAg had clinical value in predicting the occurrence of liver cancer in patients with HBV-related cirrhosis. Conclusion Age,HBsAg,PreS1Ag,PreS1Ag/HBsAg are risk factors for the occurrence of liver cancer in patients with HBV-related liver cirrhosis.HBsAg,PreS1Ag,PreS1Ag/HBsAg have clinical value in predicting the occurrence of liver cancer in patients with HBV-related liver cirrhosis.

Key words: hepatitis B virus, liver cirrhosis, pre-S1 antigen, hepatitis B surface antigen, PreS1Ag/HBsAg ratio, liver cancer