Abstract: Objective To investigate the safety and effectiveness of simultaneous transurethral resection of bladder tumor(TURBT) and transurethral resection of prostate(TURP) in treatment of non-muscle-invasive bladder cancer(NMIBC) patients complicated by benign prostatic hyperplasia(BPH).
Methods The clinical data of 120 cases of NMIBC patients complicated by BPH were analyzed retrospectively.53 patients underwent simultaneous TURBT and TURP as the observation group,and the remaining 67 patients underwent TURBT alone as the control group.The perioperative conditions of the two groups were compared.Residual urine volume(RUV),maximum urine flow rate(MFR),international prostate symptom score(IPSS),and quality of life(QOL) score before and 6 months after surgery were evaluated.The tumor recurrence,metastasis and progress were followed up and counted.
Results The operation time(125.44±25.43)min,intraoperative blood loss(110.21±11.84)ml,postoperative bladder irrigation time(30.21±6.85)h,catheter indwelling time(5.62±1.13)d and hospital stay(12.17±2.33)d,which were higher than those of the control group [(76.85±21.03) min,(76.85±9.43)ml,(22.79±5.61)h、(4.19±0.92)d,(9.01±2.14)d],the differences were statistically significant(P<0.05).At 6 months after surgery,the MFR of the observation group[(21.23±2.27)ml/s] was higher than the control group[(9.79±1.78)ml/s],the RUV(15.82±2.33)ml,IPSS score(5.14±1.02),QOL score(1.39±0.41) of the observation group were lower than the control group[(70.21±15.94)ml,(20.11±3.48),(3.25±0.72)](P<0.05).The incidence of postoperative complications was 15.09% in the observation group,which was no significant difference with 5.97% in the control group(P>0.05). The recurrence rate(24.53%),metastasis rate(1.89%),and tumor progression rate(11.32%) of the observation group were no statistically significant difference with the control group(24.53%,1.89%,11.32%)(P>0.05).
Conclusion Simultaneous TURBT and TURP is safe and effective for NMIBC with BPH,which can improve the BPH symptoms and quality of life of patients,and does not increase the risk of tumor recurrence,metastasis and progression.

Key words: non-invasive bladder cancer, benign prostatic hyperplasia, transurethral resection of bladder tumor, transurethral resection of prostate; , safety, prognosis